Protein
L-ornithine/L-arginine 3-hydroxylase
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
Function
Alpha-ketoglutarate-dependent dioxygenase that in vitro catalyzes the regio- and stereoselective hydroxylation of L-ornithine and L-arginine, leading to (3S)-3-hydroxy-L-ornithine and (3S)-3-hydroxy-L-arginine, respectively. Cannot use L-lysine, D-ornithine, or D-arginine as substrate.
Similarity
Belongs to the clavaminate synthase family.
Sequence
MHRLALTAQDNLAVAPMLADLAGRYPDIEDPELIRSAPVLAAKGLPPHLLAFLDDFRLREPSALCVISGLDVDQDRLGPTPEHWRDSQIGSRSLNLEIFFLLCGAALGDVFGWATQQDGRIMHDVLPIKGHEHYELGSNSLQHLSWHTEDSFHPCRGDYVALMCLKNPYEAETMVCDAGDLDWPNLDVDALFEPVFTQMPDNSHLPQNTAESTGDPTKDRLRARSFELIKSWNENPVRRAVLYGDRQNPYMALDPYHMKMDDWSERSLEAFQALCEEIEAKMQDVVLHPGDIAFIDNFRAVHGRRSFRARYDGSDRWLKRLNITRNLRGSRAWRPAPDDRVIY