Protein
Protopine 6-monooxygenase
Organism
Papaver somniferum
Function
Catalyzes the conversion of protopine and allocryptopine to dihydrosanguinarine and dihydrochelerythrine, respectively, in the biosynthesis of isoquinoline alkaloid sanguinarine.
Similarity
Belongs to the cytochrome P450 family.
Sequence
MDFSSLLLLLLNTWISAYSMAALLALVLVYNLRMTKSSSSKTTSLKGKKIITRPPAVTGAWPVFGHLHLFGSGEHPHEMLSKLAEKYGPSFTMKFGKHTTLVVSDTRVVKECFTTNDTLFSNRPSTIAFDLMTYATDSIAFTPYSPYWRELRKISTLKLLSNNRLESIKQLRTSEVSVCFKELYDLTNKKNDNGAPVPIDLKRWFDEVSNNVIMRVIFGKQNFGSKIVLGEDQEAVHYKKIMDELSRLSSLTMLSDMVPLLGWLDYFKGDLRAMKRNGKELNSILQKWLEEHKSKKSSDARQDFMDVMLSISKDTQLYGHDQDTFIKATCLAMIMGGTNSTEVALTWILSLLMNNRCALHKAREEIDLLVGKDRQVEDSDVKNLTYMNAIIKETMRLYPLGFLLERDTKEDCEVSGFNIKGGTRLLINVWKLQRDPNVWTDPMEFKPERFLTENADIDVGGQHFELLPFGAGRRVCPGVSFALQFMHLVLARLIHGYDMETLNGEDVDLSVSSGGHVNIKSTPLELILTPRLHPELYDCET