About Products Protein Database Contact

CYP71AV8

Gene
CYP71AV8
Protein
Cytochrome P450 71AV8
Organism
Cichorium intybus
Length
496 amino acids
Function
Valencene oxidase, which preferentially hydroylates the C2 position of (+)-valencene in the trans-orientation, producing trans-nootkatol that can be further oxidized to (+)-nootkatone. Can also catalyze the three-step conversion of germacrene A to germacra-1(10),4,11(13)-trien-12-oic acid and the partial conversion of the non-natural substrate amorpha-4,11-diene into artemisinic alcohol and artemisinic aldehyde.
Similarity
Belongs to the cytochrome P450 family.
Mass
56.135 kDa
Sequence
MEISIPTTLGLAVIIFIIFKLLTRTTSKKNLLPEPWRLPIIGHMHHLIGTMPHRGVMELARKHGSLMHLQLGEVSTIVVSSPRWAKEVLTTYDITFANRPETLTGEIVAYHNTDIVLAPYGEYWRQLRKLCTLELLSNKKVKSFQSLREEECWNLVKDIRSTGQGSPINLSENIFKMIATILSRAAFGKGIKDQMKFTELVKEILRLTGGFDVADIFPSKKLLHHLSGKRAKLTNIHNKLDNLINNIIAEHPGNRTSSSQETLLDVLLRLKESAEFPLTADNVKAVILDMFGAGTDTSSATIEWAISELIRCPRAMEKVQTELRQALNGKERIQEEDLQELNYLKLVIKETLRLHPPLPLVMPRECREPCVLGGYDIPSKTKLIVNVFAINRDPEYWKDAETFMPERFENSPITVMGSEYEYLPFGAGRRMCPGAALGLANVELPLAHILYYFNWKLPNGKTFEDLDMTESFGATVQRKTELLLVPTDFQTLTAST