CYP51

Gene

CYP51

Protein

Eburicol 14-alpha-demethylase

Organism

Uncinula necator

Length

524 amino acids

Function

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity).

Similarity

Belongs to the cytochrome P450 family.

Mass

59.84 kDa

Sequence

Protein

Gene

CYP51

Protein

Eburicol 14-alpha-demethylase

Organism

Penicillium italicum

Length

515 amino acids

Function

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.

Similarity

Belongs to the cytochrome P450 family.

Mass

58.137 kDa

Sequence

MDLVPLVTGQILGIAYYTTGLFLVSIVLNVIKQLIFYNRKEPPVVFHWIPFIGSTIAYGMDPYQFFFASRAKYGDIFTFILLGKKTTVYLGVEGNEFILNGKLKDVNAEEVYGKLTTPVFGSDVVYDCPNSKLMEQKKFIKYGLSQEALESYVPLIADETNAYIKSSPNFKGQSGTIDLAAAMAEITIFTAARTLQGEEVRSKLTSEFADLFHDLDLGFSPINFMLPWAPLPHNASAIKHTTYARDLSGNYPSATGSWRRRQRRRQDKSKGTDMISNLMRCVYRDGTPIPDKEIAHMMITLLMAGQHSSSAISCWILLRLASQPEMAEKLHAEQIKNLGADLPPLQYKDMDKLPLLRNVIKETLRLHSSIHTLMRKVKNPMPVPGTDFVVPPSHTLLSSPGVTARDERHFRDPLRWDPHRWESRVEVEDSSDTVDYGYGAVSKGTRSPYLPFGAGRHRCIGEKFAYLNLEVIVATLVREFRFFNPEGMEGVPDTDYSSLFSRPVQPATVRWEVRS

Protein

Gene

CYP51

Protein

Eburicol 14-alpha-demethylase

Organism

Penicillium italicum

Length

515 amino acids

Function

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.

Similarity

Belongs to the cytochrome P450 family.

Mass

58.137 kDa

Sequence

Protein

Lanosterol 14-alpha demethylase: CYP51

Gene

CYP51

Protein

Lanosterol 14-alpha demethylase

Organism

Cunninghamella elegans

Length

512 amino acids

Function

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity).

Similarity

Belongs to the cytochrome P450 family.

Mass

57.677 kDa

Sequence

MAIVSQISRFITFTIISMGYSVLAVGVALTIHILSQLIVPKNPNEPPNVFSLIPVLGNAVQFGMNPVAFLQECQKKYGDVFTFTMVGKRVTVCLGADGNQFVFNSKQNLSSAAEAYNHMTKYVFGPDVVYDAPHAVFMEQKKFIKAGLNSDCFRQHVPMIVQETEEFFKKFNKPTGFIEAYETFGSLIIYTASRCLMGKEIRASLDGNVAKLYYDLDQGFKPINFIFPNLPLPSYRRRDVACKKMADLYSSIIQRRKDEKDNNNADLLQALMDATYKDGTHIPDHHIAGMMIAVLFGGQHTSATTSAWTILELANRPDIIKALREEQIEKLGSLKADLTFDNLKDLPLLEAAIRETLRLHPPIFQMMRRVVADKIVYEKNGMEIPKGNFICAAPGVTQVDPTYFNEPTTYNPYRWIEKTDPVHQLEQGDDANIDYGFGAVGISSKSPFLPFGAGRHRCIGEQFGYLQLKTVISTFIRTFDFDLDGKSVPKSDYTSMVVVPEHTAKVRYTWRE

Protein

Gene

cyp51

Protein

Lanosterol 14-alpha demethylase

Organism

Danio rerio

Length

499 amino acids

Function

Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.

Similarity

Belongs to the cytochrome P450 family.

Mass

57.001 kDa

Sequence

MTILEVGSQLIESAVLQMSLTSVLLTASVFTLTLGYFSKLLFTQHSSEHTKYPPHIPSSLPFLGQAVAFGRSPIEFLEKAYEQYGPVVSFTMVGKTFTYLLGSDAAALMFNSKNEDLNAEDVYARLTTPVFGKGVAYDVPNPLFLEQKKMLKTGLNIAQFKQHVEIIEEETKDYFRRWGESGERNLFDALSELIILTASRCLHGCEIRSLLDERVAQLYADLDGGFTHAAWLLPGWLPLPSFRRRDRAHLEIKKIFYNVIKKRREDTEKHDDILQTLIDATYKDGRPLSDDEIAGMLIGLLLAGQHTSSTTSAWMGFFLARDRALQERCYSEQKSVCGEELPPLHYDQLKDLSLLDRCLKETLRLRPPIMTMMRMAKTPQKVGEYTIPPGHQVCVSPTVNHRLQDTWAERLDFDPDRYLHDNPAAGEKFAYIPFGAGRHRCIGENFAYVQIKTIWSTLLRMFDFELVDGHFPPVNYTTMIHTPHNPIIRYTRRNTQPQQ

Protein

Gene

CYP51

Protein

Obtusifoliol 14-alpha demethylase

Organism

Sorghum bicolor

Length

492 amino acids

Function

Catalyzes the 14-alpha demethylation of obtusifoliol to 4 alpha-methyl-5 alpha-ergosta-8,14,24(28)-trien-3 beta-ol.

Similarity

Belongs to the cytochrome P450 family.

Mass

55.653 kDa

Sequence

MDLADIPQQQRLMAGLALVVATVIFLKLLLSFRSGGGKKRLPPTIPGAPVVGGLVKFMRGPIPMIREQYAALGSVFTVPIITRRITFLIGPEVSAHFFKGNEAEMSQQEVYRFNVPTFGPGVVFDVDYSVRQEQFRFFTEALRANKLRSYVDQMVAEAEEYFSKWGESGTVDLKYELEHLIILTASRCLLGREVREKLFDDVSALFHDLDNGIQPISVLFPYLPIPAHKRRDKARARLAEIFATIIKSRKASGQSEEDMLQCFIDSKYKNGRPTTEGEVTGLLIAALFAGQHTSSITSTWTGAYMLRFKQYFAEAVEEQKDVMKRHGDKIDHDILAEMDVLYRCIKEALRLHPPLIMLLRQSHSDFTVTTKEGKEYDIPKGHIVATSPSFANRLPHIYKNPDSYDPDRFGPGREEDKAAGAFSYISFGGGRHGCLGEPFAYLQIKAIWTHLLRNFEFELVSPFPENDWNAMVVGIKGEVMVNYKRRKLVVDN

Protein

Gene

CYP51

Protein

Obtusifoliol 14-alpha demethylase

Organism

Sorghum bicolor

Length

492 amino acids

Function

Catalyzes the 14-alpha demethylation of obtusifoliol to 4 alpha-methyl-5 alpha-ergosta-8,14,24(28)-trien-3 beta-ol.

Similarity

Belongs to the cytochrome P450 family.

Mass

55.653 kDa

Sequence

Protein

Sterol 14-alpha demethylase: CYP51

Gene

CYP51

Protein

Sterol 14-alpha demethylase

Organism

Trypanosoma cruzi (strain CL Brener)

Length

481 amino acids

Function

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.

Similarity

Belongs to the cytochrome P450 family.

Mass

54.683 kDa

Sequence

MFIEAIVLALTALILYSVYSVKSFNTTRPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKKKLPS

Protein

Gene

CYP51

Protein

Sterol 14-alpha demethylase

Organism

Trypanosoma cruzi (strain CL Brener)

Length

481 amino acids

Function

Similarity

Belongs to the cytochrome P450 family.

Mass

54.683 kDa

Sequence

Protein

Sterol 14-alpha demethylase: CYP51

Gene

cyp51

Protein

Probable lanosterol 14-alpha demethylase

Organism

Dictyostelium discoideum

Length

466 amino acids

Function

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity).

Similarity

Belongs to the cytochrome P450 family.

Mass

52.686 kDa

Sequence

MIGTIAVLVIAILVIFAFKKSPSNIPPIVETIPFIGCFYQFAKNPLQLVRNSYDRLGEIFTLHLMGFKMTFVLGPEAQALFFRGTDEELSPKEAYRFVTPVFGKGVVYDSETEIMYEQLRFVKNGLVLSQLKKAVGIIQEETEKYFETKWGDSGEIDLLYEMNKLTILTASRCLMGKSINKSLGQSGQLADLYHELEEGLNPISFFFPNLPLPSFKKRDAARAKVAAIFHSIIQERRRSTDDSVDDVLYTLMNSKYKDGSVLEDEQIVGLMIGLLFAGQHTSSITLTYTIFYLLNNLEYFDETQKDINDIVQKENQGEINFDGLKRMNRLETVIREVLRLHPPLIFLMRKVMTPMEYKGKTIPAGHILAVSPQVGMRLPTVYKNPDSFEPKRFDVEDKTPFSFIAFGGGKHGCPGENFGILQIKTIWTVLSTKYNLEVGPVPPTDFTSLVAGPKGPCMVKYSKKQK

Protein

Probable lanosterol 14-alpha demethylase: cyp51

Gene

CYP51

Protein

Obtusifoliol 14-alpha demethylase

Organism

Triticum aestivum

Length

453 amino acids

Function

Catalyzes the 14-alpha demethylation of obtusifoliol to 4 alpha-methyl-5 alpha-ergosta-8,14,24(28)-trien-3 beta-ol.

Similarity

Belongs to the cytochrome P450 family.

Mass

51.644 kDa

Fragment

single

Sequence

RPPPTIPGAPVVGGLLRFLRGPIPLIRAEYARLGPVFTVPILTRRITFLIGPDVSAHFFKSNESDMSQQEVYRFNVPTFGPGVVFDVDYQVRQEQFRFFTEALRANKLRSYVDQMVAEAEEYFSKWGESGTVDLKYELEHLIILTASRCLLGREVREKLFDDVSALFHDLDNGMLPISVIFPYLPIPAHRRRDQARTRLAEIFATIIKSRKASGQSEEDMLQCFIDSKYKNGRQTTESEVTGLLIAALFAGQHTSSITSTWTGAYLLKFQQYFAEAVEEQKEVMKRHGDKIDHDILAEMDVLYRCIKEALRLHPPLIMLLRQSHSDFSVTTREGKEFDIPKGHIVATSPAFANRLPHIFKNPDSYDPDRFAAGREEDKVAGAFSYISFGGGRHGCLGEPFAYLQIKAIWTHLLRNFEFELVSPFPENDWNAMVVGIKGEVMVNYKRRKLIVDN

Protein

Gene

CYP51

Protein

Obtusifoliol 14-alpha demethylase

Organism

Triticum aestivum

Length

453 amino acids

Function

Catalyzes the 14-alpha demethylation of obtusifoliol to 4 alpha-methyl-5 alpha-ergosta-8,14,24(28)-trien-3 beta-ol.

Similarity

Belongs to the cytochrome P450 family.

Mass

51.644 kDa

Fragment

single

Sequence

Protein

Gene

cyp51

Protein

Lanosterol 14-alpha demethylase

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)

Length

452 amino acids

Function

Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.

Similarity

Belongs to the cytochrome P450 family.

Mass

51.681 kDa

Sequence

MTAVKEVPRVSGGEEEHGHLEEFRTDPIGLMKRVREECGDVGWFQLADKQVILLSGAEANEFFFRSSDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEHMKGHATTIEAEVRKMIEGWGESGEIDLLEFFAELTIYTSTACLIGLKFRNQLDSRFANYYHLLERGTDPLCYVDPYLPIESFRIRDEARAGLVELVQDVMHGRIANPPKDKSDRDMLDVLVSIKDEDGNPRFTANEITGMFISLMFAGHHTSSGTSSWTLIELLRHPEFYAKVQQELDDLYADGQEVSFHALRQIPSLDNALKETLRLHPPLIILMRVAQDEFEVAGYPIHKGQMVAASPAISNRIPEDFPNPDDFDPDRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEFEMAQPPESYQNDHSKMVVQLARPAKVRYRRRVRD

Protein

Gene

cyp51

Protein

Lanosterol 14-alpha demethylase

Organism

Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)

Length

452 amino acids

Function

Similarity

Belongs to the cytochrome P450 family.

Mass

51.681 kDa

Sequence

Protein

Gene

cyp51

Protein

Lanosterol 14-alpha demethylase

Organism

Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

Length

451 amino acids

Function

Similarity

Belongs to the cytochrome P450 family.

Mass

50.878 kDa

Sequence

MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV

Protein

Gene

cyp51

Protein

Lanosterol 14-alpha demethylase

Organism

Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

Length

451 amino acids

Function

Similarity

Belongs to the cytochrome P450 family.

Mass

50.878 kDa

Sequence

Protein

Gene

cyp51

Protein

Lanosterol 14-alpha demethylase

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

451 amino acids

Function

Similarity

Belongs to the cytochrome P450 family.

Mass

50.878 kDa

Sequence

Protein