CYP11B1

Cytochrome P450 11B1, mitochondrial

503 amino acids

Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

Belongs to the cytochrome P450 family.

57.847 kDa

MALWAKARVRMAGPWLSLHEARLLGTRGAAAPKAVLPFEAMPRCPGNKWMRMLQIWKEQSSENMHLDMHQTFQELGPIFRYDVGGRHMVFVMLPEDVERLQQADSHHPQRMILEPWLAYRQARGHKCGVFLLNGPQWRLDRLRLNPDVLSLPALQKYTPLVDGVARDFSQTLKARVLQNARGSLTLDIAPSVFRYTIEASTLVLYGERLGLLTQQPNPDSLNFIHALEAMLKSTVQLMFVPRRLSRWMSTNMWREHFEAWDYIFQYANRAIQRIYQELALGHPWHYSGIVAELLMRADMTLDTIKANTIDLTAGSVDTTAFPLLMTLFELARNPEVQQAVRQESLVAEARISENPQRAITELPLLRAALKETLRLYPVGITLEREVSSDLVLQNYHIPAGTLVKVLLYSLGRNPAVFARPESYHPQRWLDRQGSGSRFPHLAFGFGVRQCLGRRVAEVEMLLLLHHVLKNFLVETLEQEDIKMVYRFILMPSTLPLFTFRAIQ

CYP11B1

Cytochrome P450 11B1, mitochondrial

503 amino acids

Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

Belongs to the cytochrome P450 family.

57.573 kDa

MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN

CYP11B1

Cytochrome P450 11B1, mitochondrial

503 amino acids

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Belongs to the cytochrome P450 family.

57.644 kDa

MALRAKAEVCMAAPWLSLQRARALGTRATRVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEHLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLNPRRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALRKKVVQNARESVTLDIQPSIFHYTIEASNLALFGERLGLVGHSPSSASLSFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELALSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSTFPLLTFRAIN

CYP11B1

Cytochrome P450 11B1, mitochondrial

503 amino acids

Converts 11-deoxycorticosterone to corticosterone and 18-hydroxycorticosterone, and also produces aldosterone. May play a role in the biosynthesis of glucocorticoids as well as mineralocorticoids. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

Belongs to the cytochrome P450 family.

57.34 kDa

MAIWAKAEAWLAGPWLALNRARTLGTRAVLAPKGVLPFEAIPQFPGKKWMRVLQLWREQGFENNHLEMHQTFQELGPIFRFDVGGRNMVLVMLPEDVERCQKVEGLHPQRDVPGPWLAYRHLRGHKCGVFLLNGPTWRLDRLQLNPGVLSLQAMQKFTPLVDGVARDFSQALRARVMQNARGSLTLDIKPSIFRYTIEASNLVLFGERLGLLAHQPNPESLDFIHALEVMFKSTVQLMFMPRSLSRWTSTGTWKEHFEAWDCIFQYANKAIQRLYQELTLGHPWHYSGVVAELLTHANMTVDAIKANSIDLTAGSVDTTAYPLLMTLFELARNPEVQQALRQESLAAAARISENPQKAITELPLLRAALKETLRLYPVGIFLDRCVTSDLVLQNYHIPAGTLVKVLLYSLGRNPAVFARPERYHPQRWLDNQGSGTRFPHLAFGFGMRQCLGRRLAQVEMLLLLHHVLKNFLVETLVQEDIKMIYRFIMTPSTLPLLTFRAIS

CYP11B1

Cytochrome P450 11B1, mitochondrial

503 amino acids

Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

Belongs to the cytochrome P450 family.

57.784 kDa

MALWAKARVWMAGPWLSLHRARPLGTRASAAPKAVLPFEAMPRCPGNKWMRVLQIWKEQGSENMHLDMHQTFQELGPIFRYDVGGRHMVFVMLPEDVERLQQAESLHPQRMLLEPWLAYRQARGHKCGVFLLNGPQWRLDRLRLNPDVLSLPALQKYTPLVDGVARDFSQTLKARVLQNARGSLTLDIAPSVFRYTIEASTLVLYGERLGLLTQQPNPDSLNFIHALEAMFKSTVQLMFVPRRLSRWTSSSMWREHFEAWDYIFQYANRAIQRIYQELALGHPWHYSGIVAELLMRADMTLDTIKANTIDLTAGSVDTTAFPLLMTLFELARNPEVQQALRQESLVAEARISENPQRATTELPLLRAALKETLRLYPVGITLERQVSSDLVLQNYHIPAGTLVKVLLYSLGRNPAVFARPESYHPQRWLDRQGSGSRFPHLAFGFGMRQCLGRRVAEVEMLLLLHHVLKNFLVETLAQEDIKMVYRFILMPSTLPLFTFRAIQ

CYP11B1

Cytochrome P450 11B1, mitochondrial

500 amino acids

Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

Belongs to the cytochrome P450 family.

57.82 kDa

MAFRLKSDVRLAGSWLCLRGARALGTRAVTASKASVLPFEVIPQHQGNKRQRVLQFWKEQNHDDLHLEMHQTFQELGPIFRCDVGSTRIVAVMLPEDCARLHQAESPYPHRMHLEPWMAYREHRRQNLGVFLLNGPEWLSNRRWLNPNVLSPKAVQNLLPMVDTVARDFSEALKQKVLQSAQGSLTMDMQPDIHKYTVEVSNFALFGERLGLFGCNPSSQSLKFIHALEAVFKTTTQLMFLPRSLSRWMRSQAWKEHFEAWDYISEYAENRIQKKYEELARGCSQYNSIVANLMLQGNLPLRAMKANIMDLVAGSVDTTALPLMMTLFELARNPTVQQALRQESMATEPNIYENPQRLRMELPLLWAAIKETLRMYPVGLFLERFLTSPLVLQNYHIPAGTLVHLNLYSMGRNPEVFLSPEHYNPQRWLENKETYKHLAFGFGVRQCIGRRLAEVEMLLFLHHVLKSFCVETAFQEDVKFAYRFVMMPTSAPLLTFRPVS

CYP11B1

Cytochrome P450 11B1, mitochondrial

499 amino acids

Forms corticosterone from 11-deoxycorticosterone. Possesses high and nearly equal 11-beta-hydroxylase and 19-hydroxylase activities and a lower 18-hydroxylase activity. Involved in the formation of the precursor of 19-nor-deoxycorticosterone, a very potent mineralocorticoid involved in the development of essential hypertension.

Belongs to the cytochrome P450 family.

56.821 kDa

MALRAKADVWLARPWQCLPRTRALGTTAALAPNTLRPFEAIPQYSRNRWLKMLQILREEGQEGLHLEMHEAFRELGPIFRYSMGRTQVVYVMLPEVAEKVFQADSTQPSRTLLEPWVAHREHRGLSRGVFLLNGPEWRFNRLRINPHMLSPKAVQKFVPMVDMVARDFLEFLKKKVLANAHGSLSMNFYSSMFNYTIEASHFVLFGERLGLLGDDLNSGSLKFVNALNSIMKTTPQLMLLPSGLTRWISTRVWKENFDSWDFVSEYVTKNVKNVYQEVQSGGPQSWSVISQLVAEGALTMDAILANSLELTAGSVDTTSVPLVMTLFELARNPDVQQAVRQESLAAEASVAANPQRAMSDLPLLRAVLKETLRLYPVAVFLERILSSDLVLQNYHVPAGTILHMSLYSMGRNPAVFPRPEHYLPQRWLERNGSFQHLTFGFGVRQCLGKRLAQVEMLLLLHHVLKSFRVETQEREDVRMVYRFVLAPSSSPLLTFRPVS

Cyp11b1

Cytochrome P450 11B1, mitochondrial

499 amino acids

Forms corticosterone from 11-deoxycorticosterone.

Belongs to the cytochrome P450 family.

57.459 kDa

MALRVTADVWLARPWQCLHRTRALGTTAKVAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPHRMPLEPWVAHRELRGLRRGVFLLNGADWRFNRLQLNPNMLSPKAIQSFVPFVDVVARDFVENLKKRMLENVHGSMSINIQSNMFNYTMEASHFVISGERLGLTGHDLKPESVTFTHALHSMFKSTTQLMFLPKSLTRWTSTRVWKEHFDSWDIISEYVTKCIKNVYRELAEGRQQSWSVISEMVAQSTLSMDAIHANSMELIAGSVDTTAISLVMTLFELARNPDVQQALRQESLAAEASIVANPQKAMSDLPLLRAALKETLRLYPVGSFVERIVHSDLVLQNYHVPAGTFVIIYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDMQMVFRFLLMPSSSPFLTFRPVS