Protein
Cytochrome P450 11B, mitochondrial
Organism
Lithobates catesbeiana
Function
Has 11 beta-hydroxylation, 18-hydroxylation activities and aldosterone synthetic activity. Catalyzes the final steps of glucocorticoid and mineralocorticoid biosynthesis.
Similarity
Belongs to the cytochrome P450 family.
Sequence
MLEKTAARQIGSCLMRCRTLDTTSPLWTGFSRLSTAPLIHEAREDGSLASQTLPYEAIPTTGRSAWFNLFQFWRKNSFQHMHLAMEENFQNLGPIYREKLGTHNSVNIMLPQDVARLFQSEGIFPRRMTMEAWSKHRELRNHKQGVFLLNGEAWRSDRIILNKEVLSLAGVKKFLPFLDEAAADFVTFMKKRMSKNTRGSLTVDLYADLFRFTLEASSYVLYGQRLGLLEEHPNADTLRFISAVETVLKTTLPLLYYPHQILQLFQTRLWNEHMHAWDVIFEQADRCIQNIYQEYCLGQERGYSGIMAELLLQAELPLDSIKANITELMAGGVDTTAMPLLFTLFELARNPSVQRELREEIRKAEAQNPNDLNQLLNSLPLLKGAIKETLRLYPVGITVQRHLIKDIVLHNYHIPAGTLVQVGLYPMGRSPLLFQDALRYDPARWLKREDTNFKALAFGFGSRQCIGRRIAETEITLFLMHMLKNFQIDTVSKDDIKTVFGFILMPEKPPLLTFRPI