Function
Iridoid synthase that generates the iridoid ring scaffold using the linear monoterpene 10-oxogeranial as substrate and probably couples an initial NAD(P)H-dependent reduction step with a subsequent cyclization step via a Diels-Alder cycloaddition or a Michael addition. Iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and antibacterial activities.
Sequence
MSWWWARSLGAQKEFKENGALTSYQSVGLIIGVTGIVGNSLAEILPLPDTPGGPWKVYGVARRPRPAWNTDHPIEYIQCDVASTEDTLAKLSPLTNITHIFYVAWTGSEDCEVNETMFHNVLKAVIPNAPNLRHICIQTGIKHYTGPLDPDGGIQPHDSPFTEDLPRLNAPNFYHNLEDILIEEAAKKKGLTWSVHRPALVFGFSPYSMMNIIGALSVYAVICKHENKPLIYHGAPDNSRDSWNVYADAADADLIAEHQIWAAVDSNAKNEVFNCSNGDVFKWKQMWKILAEQFEVELVGYEDGQKRMSLQERMKGKGPVWDEIVRKHKLLPTKLEDVAQWWFADIVSQSQNLVNGVNKSKENGFLGFRDSKKSFVYWIKKMRAAKIIP