coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

495 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

55.086 kDa

MLRLINKTINKNDLIKINNSKRFCSTTTNSTINKDNIYDIIIIGGGLVGSTMACSIGNNNTTKHLKVALIESSKIQTVEQSISNAIPEIRTISFNNQTIELFKSINVWDTIKSTKRVNPFNQVRVWDTSGFEGIHFQDNDIIDDGNNTTAMGYIIENNIVTSSLLSKVKQFENIELFEQLSVKSMNDYNEETIRTTSILPSVTLSNDQQLHAKLIIGADGGNSILKKQLQVPSIGRVYNQKAVVCTLKLGIKQDNNNNSSNNNNNNNNTLFQRFLPTGPIALLPLANGYANIIWSTNLMHAQYLLELDDESFLEQVKDSFLKSPSTSNSSFFEIASNLFNLNPKGLSGNEIYLPPIEGLVSKRASFPLRIDHTFNYTLPRVCFIGDASHLVHPMAGQGVNLGMADVKTLSSIIEQSVQSGYDIGDAMMLKRFEEIRKPENLKMLLSIDTLFNLFTNNSIFVTGLRNFGMSLLNNISPLKNLIIGVSKGESILKFK

coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

495 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

55.086 kDa

MLRLINKTINKNDLIKINNSKRFCSTTTNSTINKDNIYDIIIIGGGLVGSTMACSIGNNNTTKHLKVALIESSKIQTVEQSISNAIPEIRTISFNNQTIELFKSINVWDTIKSTKRVNPFNQVRVWDTSGFEGIHFQDNDIIDDGNNTTAMGYIIENNIVTSSLLSKVKQFENIELFEQLSVKSMNDYNEETIRTTSILPSVTLSNDQQLHAKLIIGADGGNSILKKQLQVPSIGRVYNQKAVVCTLKLGIKQDNNNNSSNNNNNNNNTLFQRFLPTGPIALLPLANGYANIIWSTNLMHAQYLLELDDESFLEQVKDSFLKSPSTSNSSFFEIASNLFNLNPKGLSGNEIYLPPIEGLVSKRASFPLRIDHTFNYTLPRVCFIGDASHLVHPMAGQGVNLGMADVKTLSSIIEQSVQSGYDIGDAMMLKRFEEIRKPENLKMLLSIDTLFNLFTNNSIFVTGLRNFGMSLLNNISPLKNLIIGVSKGESILKFK

coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

484 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

52.999 kDa

MLSLAKAKLAVVGIGRQCVAVRTLNGARAVHRSFSSSEHDQDSSTSENELFDIIISGGGMVGTAMACSLGLDPNLTGKKILLLEAGHEKKMDKIPETYSTRVSSISPGSATLLSGLGAWDHIVNMRCKPYNKMQVWDACSDALITFDKENLQDEMAYIVENDVIVAALTKQLQTLSDHVKVQYRTKVVKYTWPHPYHVSESIPWVQVALANGKTLHTKLLIGADGPNSMVRREAGIPTVKWNYDQSAVVAVLHLSEPTENNVAWQRFLPTGPIAMLPLSDTESSLVWSTSHQHAEELLQMDEESFVDAINSAFWSNENHSELVETAGSLFRMALSVLMPDSGSARQLPPSVSGIGPKSRVMFPLGMGHATEYIRHRVALIGDAAHRVHPLAGQGANLGFGDVSYLTQVLSQAAYNGKDIGAMQHLLEFETERQRHNLPMMTAIDLMKRLYSSNTAPMVLLRTFGLQATNAVPPLKEQIMAFASK

coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

484 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

52.999 kDa

MLSLAKAKLAVVGIGRQCVAVRTLNGARAVHRSFSSSEHDQDSSTSENELFDIIISGGGMVGTAMACSLGLDPNLTGKKILLLEAGHEKKMDKIPETYSTRVSSISPGSATLLSGLGAWDHIVNMRCKPYNKMQVWDACSDALITFDKENLQDEMAYIVENDVIVAALTKQLQTLSDHVKVQYRTKVVKYTWPHPYHVSESIPWVQVALANGKTLHTKLLIGADGPNSMVRREAGIPTVKWNYDQSAVVAVLHLSEPTENNVAWQRFLPTGPIAMLPLSDTESSLVWSTSHQHAEELLQMDEESFVDAINSAFWSNENHSELVETAGSLFRMALSVLMPDSGSARQLPPSVSGIGPKSRVMFPLGMGHATEYIRHRVALIGDAAHRVHPLAGQGANLGFGDVSYLTQVLSQAAYNGKDIGAMQHLLEFETERQRHNLPMMTAIDLMKRLYSSNTAPMVLLRTFGLQATNAVPPLKEQIMAFASK

coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

479 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

53.575 kDa

MSSLVLRGVSRVEMPTISPTLGIYTRKFASQKILQRQFDVVIVGSGPVGLALAAGLQSNPVTQSLKVGLLDIQDTMKLKDWKFETYSNRCSSLTNHTRMFFDKIGAWDFARKDRIQPFQHILASDGLTNSSIHLDQKPGSEPMAFMSENVNLQYALLNSIIDKMNNNIKKPNLEFLMPCTITKLSKGENIYRTHIHTTTHGELTTKLLIGADGRNSIVRKYANISMPGWNYLTHAVVGTLKIDPLKGPAVAFQRFLPTGPLAYLPLPDNNATFVWSTRPHIASKLLRLPEETFVKFLNASFRLDYPDLSYLYQMDFSEPSKVNEQLDWRLQVKRNSNMQVPPVITEIVSGSRAAFPLRLAHVDEYVKEGIALCGDAAHNTHPLAGQGLNTGIQDVESLISALSFAIKHGQDIGSVFSLQPYFRDRYFKNHVYLGVVDKFHKLYAMENPVVTSVRTLGLSLFDRSASLKNFILSTVANGI

coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

479 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

53.575 kDa

MSSLVLRGVSRVEMPTISPTLGIYTRKFASQKILQRQFDVVIVGSGPVGLALAAGLQSNPVTQSLKVGLLDIQDTMKLKDWKFETYSNRCSSLTNHTRMFFDKIGAWDFARKDRIQPFQHILASDGLTNSSIHLDQKPGSEPMAFMSENVNLQYALLNSIIDKMNNNIKKPNLEFLMPCTITKLSKGENIYRTHIHTTTHGELTTKLLIGADGRNSIVRKYANISMPGWNYLTHAVVGTLKIDPLKGPAVAFQRFLPTGPLAYLPLPDNNATFVWSTRPHIASKLLRLPEETFVKFLNASFRLDYPDLSYLYQMDFSEPSKVNEQLDWRLQVKRNSNMQVPPVITEIVSGSRAAFPLRLAHVDEYVKEGIALCGDAAHNTHPLAGQGLNTGIQDVESLISALSFAIKHGQDIGSVFSLQPYFRDRYFKNHVYLGVVDKFHKLYAMENPVVTSVRTLGLSLFDRSASLKNFILSTVANGI

COQ6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

479 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via ferredoxin (YAH1) and ferredoxin reductase (ARH1) to COQ6 (By similarity) (PubMed:21944752). Can also convert 3-hexaprenyl-4-aminobenzoic acid (HAB), a COQ2-prenylated pABA, to DHHB in a too step process. HAB is first hydroxylated at C5 to yield 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) which is further deaminated at C4 by COQ6 to produce DHHB (PubMed:26260787).

Belongs to the UbiH/COQ6 family.

53.527 kDa

MFFSKVMLTRRILVRGLATAKSSAPKLTDVLIVGGGPAGLTLAASIKNSPQLKDLKTTLVDMVDLKDKLSDFYNSPPDYFTNRIVSVTPRSIHFLENNAGATLMHDRIQSYDGLYVTDGCSKATLDLARDSMLCMIEIINIQASLYNRISQYDSKKDSIDIIDNTKVVNIKHSDPNDPLSWPLVTLSNGEVYKTRLLVGADGFNSPTRRFSQIPSRGWMYNAYGVVASMKLEYPPFKLRGWQRFLPTGPIAHLPMPENNATLVWSSSERLSRLLLSLPPESFTALINAAFVLEDADMNYYYRTLEDGSMDTDKLIEDIKFRTEEIYATLKDESDIDEIYPPRVVSIIDKTRARFPLKLTHADRYCTDRVALVGDAAHTTHPLAGQGLNMGQTDVHGLVYALEKAMERGLDIGSSLSLEPFWAERYPSNNVLLGMADKLFKLYHTNFPPVVALRTFGLNLTNKIGPVKNMIIDTLGGNEK

Coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

477 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

51.994 kDa

MLGVLRIQGALASAGQARLLSVRLLASKSTTDMTTNRGESTQSTSTEHFDIIIGGGGLVGTTLAAALAKNSTLADKKVLLLEGAPEFRGFNPTGPYQNRVSAINHNSIELFKSIDAWKHIESARYKPVKQMQVWESNTDALIQFQHDNFASDVACIIENDLILDAVYALAKESPNVEILNKARIQCVRLPRDSNSNHSELQLEDGRNFSCDLLIGADGANSVVRKEMNVDVFSLNYDRMGLVATLELGEDACDNSVAWQRFLPNGPVALLPLTDRLSSLVWSTTNEQAKMLQALPPTEFVDALNEAFCRQYPRVELADKAVQALNSLFGHNGSQHQVQYPPRVCGVLDKSRATFPLGFLHASSYVCNGAALVGDAAHRVHPLAGQGVNLGFSDVRYLVESLAAGAYAGFKLGDKQHLIKYERKCLAKNVPIMLGVHGLHTLYATQFSPVVLLRSLGLQLTQNLPPVKNLFMRGAMGQ

Coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

477 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

51.994 kDa

MLGVLRIQGALASAGQARLLSVRLLASKSTTDMTTNRGESTQSTSTEHFDIIIGGGGLVGTTLAAALAKNSTLADKKVLLLEGAPEFRGFNPTGPYQNRVSAINHNSIELFKSIDAWKHIESARYKPVKQMQVWESNTDALIQFQHDNFASDVACIIENDLILDAVYALAKESPNVEILNKARIQCVRLPRDSNSNHSELQLEDGRNFSCDLLIGADGANSVVRKEMNVDVFSLNYDRMGLVATLELGEDACDNSVAWQRFLPNGPVALLPLTDRLSSLVWSTTNEQAKMLQALPPTEFVDALNEAFCRQYPRVELADKAVQALNSLFGHNGSQHQVQYPPRVCGVLDKSRATFPLGFLHASSYVCNGAALVGDAAHRVHPLAGQGVNLGFSDVRYLVESLAAGAYAGFKLGDKQHLIKYERKCLAKNVPIMLGVHGLHTLYATQFSPVVLLRSLGLQLTQNLPPVKNLFMRGAMGQ

Coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

476 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

51.393 kDa

MAARIGSMAGLLCVRWWSSAQLAARGGPLVASQRWAGSSADTVYDVVVSGGGLVGSAMACALGHDIHFHDKKILLLEAGPKKALEKLSETYSNRVSSISPGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDRDNLDDMGYIVENDVIMYALTKQLEAVADRVKVLYESKAVGYSWPGAFSMADSSPWVHITLGDGSTLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEEFVDAINSAFWSDVHHTDFVDSASAMVRHAVALLKPTKVSARQLPPSIAKVDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSPLKEQIMAFASK

Coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

476 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

51.496 kDa

MAARIGPMAGLLCVRWWSTAQLAARGGPLVACRRWTSSSTDSVYDVVVSGGGMVGSAMACALGHDIHFHDKKILLLEAGPKKTLEKLSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDKDNLDDMGYIVENDVIMHAITKQLEAVADRVKVLYESKAVGYAWPGPFSLADSSPWVHITLGDGSTLQTKLLIGADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHAHAAELVSMHEEEFVDAINSAFWSDVHHTDFVDSASAMVHHAVALLKPTKVSARQLPPSVAKVDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLIHYLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSTTPLVLLRTWGLQATNAVSPLKEQIMAFASR

Coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

476 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

51.393 kDa

MAARIGSMAGLLCVRWWSSAQLAARGGPLVASQRWAGSSADTVYDVVVSGGGLVGSAMACALGHDIHFHDKKILLLEAGPKKALEKLSETYSNRVSSISPGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDRDNLDDMGYIVENDVIMYALTKQLEAVADRVKVLYESKAVGYSWPGAFSMADSSPWVHITLGDGSTLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEEFVDAINSAFWSDVHHTDFVDSASAMVRHAVALLKPTKVSARQLPPSIAKVDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSPLKEQIMAFASK

Coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

476 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

51.496 kDa

MAARIGPMAGLLCVRWWSTAQLAARGGPLVACRRWTSSSTDSVYDVVVSGGGMVGSAMACALGHDIHFHDKKILLLEAGPKKTLEKLSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDKDNLDDMGYIVENDVIMHAITKQLEAVADRVKVLYESKAVGYAWPGPFSLADSSPWVHITLGDGSTLQTKLLIGADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHAHAAELVSMHEEEFVDAINSAFWSDVHHTDFVDSASAMVHHAVALLKPTKVSARQLPPSVAKVDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLIHYLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSTTPLVLLRTWGLQATNAVSPLKEQIMAFASR

COQ6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

469 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

51.072 kDa

MAAQLARVRWGTVFAAAQKGPRVSCRRWAGASADNVYDVVVSGGGLVGAAMACALGHDIHFCDKKILLLEAGPKKVLEKLPETYSNRVSSISPGSATLLSSFGAWDHICNMRCRAFRRMQVWDACSEALIMFDKDNLDDMGYIVENDVIMHALTKQLEAVSDQVTVLYKSKAVSYTWPYPFSMADSSPWVHITLGDGRTLQTKLLIGADGHNSGVRQAAGIRNVSWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMEEEEFVDAINSAFWSDVNHTDFIDSAGSMLQSAVAFLKPTRVSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRPRLALIGDAAHRVHPLAGQGVNMGFGDISSLLHHLSTAAFNGKDLGSMSHLTSYETDRQRHNTALLAATDLLKRLYSTRATLVVLLRTWGLQATNAVSPLKEQIMAFASK

COQ6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

469 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

51.072 kDa

MAAQLARVRWGTVFAAAQKGPRVSCRRWAGASADNVYDVVVSGGGLVGAAMACALGHDIHFCDKKILLLEAGPKKVLEKLPETYSNRVSSISPGSATLLSSFGAWDHICNMRCRAFRRMQVWDACSEALIMFDKDNLDDMGYIVENDVIMHALTKQLEAVSDQVTVLYKSKAVSYTWPYPFSMADSSPWVHITLGDGRTLQTKLLIGADGHNSGVRQAAGIRNVSWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMEEEEFVDAINSAFWSDVNHTDFIDSAGSMLQSAVAFLKPTRVSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRPRLALIGDAAHRVHPLAGQGVNMGFGDISSLLHHLSTAAFNGKDLGSMSHLTSYETDRQRHNTALLAATDLLKRLYSTRATLVVLLRTWGLQATNAVSPLKEQIMAFASK

COQ6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

468 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6 (By similarity). Is able to perform the deamination reaction at C4 of 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) to produce DHHB when expressed in yeast cells lacking COQ9, even if utilization of para-aminobenzoic acid (pABA) involving C4-deamination seems not to occur in bacteria, plants and mammals, where only C5 hydroxylation of HHB has been shown (PubMed:26260787).

Belongs to the UbiH/COQ6 family.

50.87 kDa

MAARLVSRCGAVRAAPHSGPLVSWRRWSGASTDTVYDVVVSGGGLVGAAMACALGYDIHFHDKKILLLEAGPKKVLEKLSETYSNRVSSISPGSATLLSSFGAWDHICNMRYRAFRRMQVWDACSEALIMFDKDNLDDMGYIVENDVIMHALTKQLEAVSDRVTVLYRSKAIRYTWPCPFPMADSSPWVHITLGDGSTFQTKLLIGADGHNSGVRQAVGIQNVSWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEKFVDAVNSAFWSDADHTDFIDTAGAMLQYAVSLLKPTKVSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLAHHLSTAAFNGKDLGSVSHLTGYETERQRHNTALLAATDLLKRLYSTSASPLVLLRTWGLQATNAVSPLKEQIMAFASK

COQ6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

468 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6 (By similarity). Is able to perform the deamination reaction at C4 of 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) to produce DHHB when expressed in yeast cells lacking COQ9, even if utilization of para-aminobenzoic acid (pABA) involving C4-deamination seems not to occur in bacteria, plants and mammals, where only C5 hydroxylation of HHB has been shown (PubMed:26260787).

Belongs to the UbiH/COQ6 family.

50.87 kDa

MAARLVSRCGAVRAAPHSGPLVSWRRWSGASTDTVYDVVVSGGGLVGAAMACALGYDIHFHDKKILLLEAGPKKVLEKLSETYSNRVSSISPGSATLLSSFGAWDHICNMRYRAFRRMQVWDACSEALIMFDKDNLDDMGYIVENDVIMHALTKQLEAVSDRVTVLYRSKAIRYTWPCPFPMADSSPWVHITLGDGSTFQTKLLIGADGHNSGVRQAVGIQNVSWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEKFVDAVNSAFWSDADHTDFIDTAGAMLQYAVSLLKPTKVSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLAHHLSTAAFNGKDLGSVSHLTGYETERQRHNTALLAATDLLKRLYSTSASPLVLLRTWGLQATNAVSPLKEQIMAFASK

coq6

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

464 amino acids

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Belongs to the UbiH/COQ6 family.

50.743 kDa

MRCLGGSSLSRLLRMLSQSQGRALSSTGPAVYDVVISGGGMVGTAMACALGSDPHLQHKKVLLLEAGNRKPFDHLPENFSNRVSSITPGSATLLASFGAWDHILAMRLKPYKRMQVWDACSDALITFDKDALEDMGYIVENDIIIEALTKQLELMSDHVEVMYRSRALSYSWPPPYNNGKATPWVEIELADGQRLHTKLLIGADGHNSMVRSAAGMQSVQWNYNHAAVVATLHLSEATDNNVAWQRFLPTGPIALLPLSDTCSSLVWSTSPEHASELVSMDEESFVDTVNSAFWSNENHSEFITSAGSLLHSALSFFMPTGSSPRQLPPSVSRVEQNSRASFPLGLKHATEYIRHRVALIGDAAHRVHPLAGQGVNMGFGDVACLAHHLSQAAFNGSDLGSTKHLLEYETERQRHNLPLMAAVDLLKRLYNTKQPPIVLLRTLGLQATNALTPVKEQIMAFASK