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COPE

Gene
COPE
Protein
Coatomer subunit epsilon
Organism
Bos taurus
Length
308 amino acids
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Similarity
Belongs to the COPE family.
Mass
34.481 kDa
Sequence
MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKPSSPERDVERDVFLYRAYLAQRKYGVVLDEIKPSSAPELQAVRMFAEYLASDSRRDAIVAELDREMSRSVDVTNTTFLLMAASIYFYDQNPDAALRTLHQGDSLECMAMTVQILLKLDRLDLARKELKKMQDQDEDATLTQLATAWVSLAAGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGVLQEALDKDSGHPETLINLVVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYRAKENDFDRLVLQYAPSA

Gene
COPE
Protein
Coatomer subunit epsilon
Organism
Gallus gallus
Length
308 amino acids
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
Similarity
Belongs to the COPE family.
Mass
34.369 kDa
Sequence
MASGAGAGPAGQGGEADELFDVKNSFYIGAYQAAINEAQRIKPSNPEKETERDVFLFRSYIAQRKYGVVLDEIKANASPELQAVRMFAEYLSNESQRDAIVADLDKKMAKSVDVANTTFLLMAASIYFHDKNPDAALRTLHQGESLECMAMMIQILLKLDRLDLARKELKKMQEQDEDATLTQLATAWVNLAIGGEKLQDAYYIFQEMADKCSSTLLLLNGQAACYMAQGKWDDAEGVLQEALDKDSGHPETLINFVVLSQHLGKPPEVTNRYLSQLKDAHKNHPFIKEYQAKENDFDRLAMQYAPSA

Gene
COPE
Protein
Coatomer subunit epsilon
Organism
Cricetulus griseus
Length
308 amino acids
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Similarity
Belongs to the COPE family.
Mass
34.523 kDa
Sequence
MAPPAPGAASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPDREVERDVFLYRAYIAQRKYGVVLDEIKPSSAPELQAVRMFADYLATENRRDAIVVELDREMSRSVDVTNTTFLLMAASVYFHDQNPDAALRTLHQGDSLECMAMTIQILLKLDRLDLARKELKKMQDQDEDATLTQLATAWVNLAVGGEKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINLIVLSQHLGKPPEVTNRYLSQLKDAHRTHPFIKEYQAKENDFDRLALQYAPSA

Gene
COPE
Protein
Coatomer subunit epsilon
Organism
Homo sapiens
Length
308 amino acids
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Similarity
Belongs to the COPE family.
Mass
34.482 kDa
Sequence
MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAYLAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFLLMAASIYLHDQNPDAALRALHQGDSLECTAMTVQILLKLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRLVLQYAPSA

Gene
Cope
Protein
Coatomer subunit epsilon
Organism
Mus musculus
Length
308 amino acids
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Similarity
Belongs to the COPE family.
Mass
34.567 kDa
Sequence
MAPPVPGAVSGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPEREVERDVFLYRAYLAQRKYGVVLDEIKPSSAPELQAVRMFAEYLASENQRDSIVLELDREMSRSVDVTNTTFLLMAASIYFHDQNPDAALRTLHQGDGLECMAMTIQILLKLDRLDLARKELKKMQDQDEDATLTQLATAWVNLAVGGEKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINLIVLSQHLGKPPEVTNRYLSQLKDAHRAHPFIKEYQAKENDFDRLAMQYAPSA

Gene
COPE
Protein
Coatomer subunit epsilon
Organism
Pongo abelii
Length
308 amino acids
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Similarity
Belongs to the COPE family.
Mass
34.457 kDa
Sequence
MAPPAPGPTSGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPETDVERDVFLYRAYLAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFLLMAASIYLHDQNPDAALRALHQGDSLECTAMTVQILLKLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRLVLQYAPSA

Gene
cope
Protein
Coatomer subunit epsilon
Organism
Dictyostelium discoideum
Length
300 amino acids
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
Similarity
Belongs to the COPE family.
Mass
34.34 kDa
Sequence
MSDDILFESKNYFYLGNYQSTINEINKKSRQIIEKSLKAESDYFLYRCYIAQGNYDLVLQETKNNRGSGEDPTIAGLQLLASYLSKPDENREGTLITITQWISDGVVKFNYHLQVIIATIYFNEQLYDEALQILNNCDHIEGLSMLIQIFLKIDRLDLAQKAYDTMKKIIDPDATPALLSLAWINIYNGEEKLKSALSSFEEMAERYGPTPLLLNGQAVCAIGMKRFEKAESLLLESIEKNPKNSDTLANLINCYINMKKPNEIIQRFINQLKTLSPKHDWTSAVNEAEALFEVSKSRFN