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COG4

Gene
cog4
Protein
Conserved oligomeric Golgi complex subunit 4
Organism
Dictyostelium discoideum
Length
911 amino acids
Function
Required for normal Golgi function.
Similarity
Belongs to the COG4 family.
Mass
106.365 kDa
Sequence
MDELIVDFNNLDSNLSIDDAKKYLQNLISRDKAIEINLKQHIKLKDDLEIQMESFDNEIPEYLTLSLKKSNELNNRISSTCQLAENLSSKVKKLDNIRERIKDTLKKVDDIIDLKNCIEGVQISIEKEDYEGAAFHINRYLSIDKSVLEDNSSEKLSIAEKKLLSMIESKYQQSLQDNDQKQVLRFCILYVPLEKPLEGIDKYCNYLKNQSKKLDAMITHYRNYIQSPKTIKPISAVSVITKIFEHFAAIIEDDLPIIKSEFGVLHCPHFILNITQQCDYYSSKVYDSFNDQFQTNKNVNDILVYKQQLEKSQQSIQDSGSGSGGGGGKVSEKIDPRNFAQFLDETSMISKATKFYEKYLIRKEHLIKSDIYQYYSKLEKEKIEKLNSIKSLIITNSRNQQLQQLPQPQQLQQQQQYQQQLQTQENKENELLKKLTQEKDKQMKQTIYSNVTKQKMNQLLGNYILLEEYFMVESVNKAIQMDSLQSLDFENNINSSNSNSSSVSGSGIGGSNTLSSSNSQQSQQSTDNTMIDFIFFVLQKSLQRAIDSHSIQTLNVICNRLCRILSQTRDNLKRIFREYIIRSSSKSVMDYQSSLQVLNNLETSSEYIIRLKKEFDSKCLKIYPIYKLDEKSKDLESSSTSSTSIEQQQQQQQQQQQQQQQQQQQQQQQQQQQEQQQENEFESNLKDDIIIIRNLLNLELKKKQENDRDQVNILSNEFLNCSKSFNKILQEEIESLFKSVQPRLKNVLNQFTLVNYEINQLEYDNNDINDPFVLQFTLEISHFFKPFQEHLSNTNYDYLVHQTIQFILKKIEGITIQQKKFTLLGGLQFGKDLRAISTYFTKISQSTIRDKFSKLNQISSFLILESISEVEDHWNENRNSPTWKLSSSEVQKILMTRIDFNHDQILKLKFN

Gene
COG4
Protein
Conserved oligomeric Golgi complex subunit 4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
861 amino acids
Function
Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG4 is required for normal endoplasmic reticulum function and is also involved in calcium regulation. Possesses ATPase activity.
Similarity
Belongs to the COG4 family.
Mass
98.666 kDa
Sequence
MEGQKSNASWESSIIEGQLSKNLARYTLLLDKLSTLSQIDKLSEVIANDYAKQSKQLNAFVQQSQSSLNKESRKLELQRTNLTTTLTQFHETVATISSSNARAKAIHDDIETVDQERALVNKTLQFVKDVRTLKNNISLAHSALETKDYLVAATAINEIRSLPDKKLIVSEFAKKVVPSSEIPEEPAILIKNWCKELTSLFQEQFMEATRTQDIKELTLMFKMFPMIGQDVLGLDLYSKYVCDIIADESRKIMSNSMENSTKFQGFFSQVLLHLFKIVSTIINDHSKVIATCYGKKHMVHVMEKVEKEADLQASLILDIFMETRKIERTIHDINEWEHSQKNEDVNIDSNQSDIETDGETEKSSIISIHDLALLIMEFSQILQNWSMYSRFYSVKWNEFSDLHPHVLQPPPPIADGKFALKLKQDKVFDEFQVFVLNHLQRSFRNSISLEELPSLNDLITAVPLNDHDNISYPVTSVLDDLILLVRKNLISVVNTGQFKLLASFLNELVKFFQNRFLVKFMQNKFKLLQSKLASNVSLKRYIPKGEEQSATSRSVSPPANKFSPLSRFTFRGAAASALTNIQSNLQAVVAEDEDSILALHHYLIYLNTLYLSKVYVHRLLSIEILEDDSQRILRDNFPFDNDAAQLQNLIINSEKLVLEQTDKLSKWAVKYLFQNILQNRVRNLLGTVFVNSASSNSSTSNQKNVSRDYSAGSNQKNYITSIEDFEDLSQINSFNSKWNQLIIPYKNILHNEAYAELLSVIVDYIVTTLEQRIWTLEFNELGVTKLDRELSLFIGNMCGLNYNLREKFLKLTQIVLLLGLDDDNFDLTTGDIKDDFNGTFDWVINSQERIKARNMKIDRTQ

Gene
COG4
Protein
Conserved oligomeric Golgi complex subunit 4
Organism
Bos taurus
Length
785 amino acids
Function
Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.
Similarity
Belongs to the COG4 family.
Mass
88.856 kDa
Sequence
MADLDSPQKLSGVPRPPDGVGGGSCSEISTELIRSLTDLQELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVTEKFAVATKEGDLPQVERFFKIFPLLGLHEEGLSKFSEYLCKQVASKAEENLLLVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYRQQFRHVQSNLMRNSTSEKIEPRELDPILTEVTLMNARSELYLRFLRKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYITMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCHKLRMGFPATTLQDIQRGVTSAVSIMHSSLQQGKFDTKGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSGKFRDLLQEGLTELNSTAIKPQVQPWINTFLSVSHNIEEEEFSDYEANDPWVQQFILNLEQQMAEFKAGLSPVIYDSLTSLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGANSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL

Gene
COG4
Protein
Conserved oligomeric Golgi complex subunit 4
Organism
Homo sapiens
Length
785 amino acids
Function
Required for normal Golgi function (PubMed:19536132, PubMed:30290151). Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (PubMed:19536132).
Similarity
Belongs to the COG4 family.
Mass
89.083 kDa
Sequence
MADLDSPPKLSGVQQPSEGVGGGRCSEISAELIRSLTELQELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEKIEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGPNSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL

Gene
Cog4
Protein
Conserved oligomeric Golgi complex subunit 4
Organism
Mus musculus
Length
785 amino acids
Function
Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.
Similarity
Belongs to the COG4 family.
Mass
88.661 kDa
Sequence
MAEVESPLKLSGAPPPPEGVGGGHCSEISTELIRSLTELQELEAVYERLCGEEKAVEKELDALLEQQNTIESKMVTLHRMGPSLQLIEGDAKQLAGMITFTCSLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEDGLSKFSEYLCKQVASKAEENLLLVLGSDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLFTLIKYLQVECDTQVEKVVNKFIKQRDYHQQFRLVQSNLMRNSATEKIEPRELDPVLTEVTLMNARSELYLRFLRKRISADFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGFYITMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSNIDCLCAMINLATRELEADFRDVLCNKLRMGFPATTLQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLAELNSSAVKPQVQPWINTFLSVSHSIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGANSGPLTWRLTPAEVRQVLALRIDFRNEDIKRLRL

Gene
COG4
Protein
Conserved oligomeric Golgi complex subunit 4
Organism
Pongo abelii
Length
785 amino acids
Function
Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.
Similarity
Belongs to the COG4 family.
Mass
89.171 kDa
Sequence
MADFDSPPKLSGVQPPSEGVGGGRCSEISAELIRSLTELQELETVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAVATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEKIEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVTVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGPNSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL

Gene
cog4
Protein
Conserved oligomeric Golgi complex subunit 4
Organism
Danio rerio
Length
781 amino acids
Function
Required for normal Golgi function (PubMed:30290151). Plays a role in the vesicular trafficking between the endoplasmic reticulum and the Golgi apparatus (By similarity).
Similarity
Belongs to the COG4 family.
Mass
87.587 kDa
Sequence
MEEAASPARRRGGPAGVSAVQTDTIEALTELEDLERVYAQLCAEEAEVQVELDALVGQQNNIETKMLSLQRMGPNLQLIEGDAVQLSGMINFTCSLAENVSSKVRQLDLTKKRLYQAIQRADDILDLKFCTDGVQTALRNQDYEQAAAHIHRYLSLDQSVIELSKQGGEGSAVEASLALLQEAERNLKTLVTTRLEEAVATGDLPQVERFFKILPLLGLHEQGLARFAQYLCSQLASKAEENLILAVGSDLGERRAPVIFADTLTLLLEGIARIVETHQPIVETYYGPGRLHTLLAHLQKECDKQAQKIVDKFIQQRDYNNKFQVVQSNMMRGMTTDKIEPRDLDPVLCEVTLMNSRAELYFRFLRRRIVADFEVADAMADEAVIQEHQQSLEQLLKNCQLSRTMQELIGYYIPMEEYYMRESVNKAVAMDTAEVGQLSSSVVDDVFYIVKKCISRALTSSSSDCVCAMINHATSVLETDFREVLVCKLRAGYPVSALQDLQRGVSSAVSLMQSSLQQGKITNLTQTLGIESQEQAKSAYLVTLNNVEVCSENISTLKKNLESDCAKLFSQGASSDHAKEKIDSCLSDLVNTSSKFKDLLQEGLQELNNTAIRPQVKPWISSFLSVSHNIEEEEFSEYEANDPFVQQLIVQLEQLMAEFKVGLSPVIYDTLTSLMTSLIAMEMEKTVFKCTFSRLGGLQFDKELRALVAYLSSVTSWTIRDKFARLTQMATILNLERVSEILDYWGPNSGPLTWRLTPAEVRQVLALRVDFRSEDIKRLRL

Gene
COG4
Protein
Conserved oligomeric Golgi complex subunit 4
Organism
Arabidopsis thaliana
Length
738 amino acids
Function
Required for normal Golgi function.
Similarity
Belongs to the COG4 family.
Mass
82.978 kDa
Sequence
MPEIEQDDAAAETVDSSTVKFGTPEALEYVRSLTDVGAMTRLLHECIAYQRSLDSDLDTLLSQRTELDRNLVQLQRSAEILDIVKADADHMLGNVRSTCDLADQVSGKVRELDLAQSRVNVTLSRIDAIVERGNCIEGVKTALESEDYESAAKFVQRFLQIDLQYKDSGSDQSEQLHASKEQLEGIAKKKLLAAIDQRDHPTILRFVRLYSPLGMETEGLQLYVGYLKKVIALRGRMEYENVVELMEQGLGQVNFVGCLTNLFKDIVMAIEENDEILRGLCGEDGVAYAICELQEECDLRGSLILKKYMDFRKLAILASDINNSPNLNILPGGASEGPDPREVELYVEEILSLMQLGEDYTEFMVSKIKSLTSVDPELLPTATKAFRNKSFSKAIQDVTRYYVILEGFFMVENVRKAIRIDEHVPDSLTTSMVDDVFYVLQSCLRRAISTSNISSVIAVLSYAGSLLGNDYHEALQQKIREPNLGARLFLGGIGVENTGTEIATALNNMDVSCEYILKLKHEIEEQCTEVFPAPADRERIKSCLSELGELSSTFKQLLNSGMEQLVATVTPRIRPVLDTVATISYELTETEYAENEVNDPWVQRLLHSVETNAAWLQPLMTSNNYDSFLHLIIDFIVKRLEVIMMQKRFSQLGGLQLDRDTRALVSHFSGMTQRTVRDKFARLTQMATILNLEKVSEILDFWGENSGPMTWRLTPAEVRRVLGLRVEFKPESIAALKL

Gene
cog4
Protein
Conserved oligomeric Golgi complex subunit 4
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
738 amino acids
Function
Component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
Similarity
Belongs to the COG4 family.
Mass
85.35 kDa
Sequence
MDISINDCTDISQIKQRFHDLQVESQRTDEKLERLLSDAQPTEKFNSLIKNMAERLVLFVGQIEELKDAFCNTTIVSEEVIERIKSVDREQNRIKECLLFVRQVRDFKECLQDLNRAMHHQQWEKAADLVHRASSTSPAIIEGKFAHAVVPTAEQPLAPMDTLKEITESLHTLFWREFHKAARNQDQKEITRYFKLFPLIGKEKEGLEAYWHFFGGIIASKARATLDEPPTHALFFAQAFTGLVEHVASIIRAHTPLVQKYYKAKNTITVIEKLQGDCDRQGSIIVNTMFDVRRIDNLVSSIASYKYILLHAKLKNRAFVSDQKELERVSLQTLHPILNEMSAIVSKWNISKIFISRLVLRLSQSDGTSNDPSVQDNLICASIFNSSKMELLLKKQLLPSLLQLETYYFRRSIETSLELEEYYTKVSPWMSSIVDDVMYVTKQVFQRAFFTVSSLFFTRFVNESLIPILRNDYYVYLSHNLLTVCNIIKAQFQRLKNANSIPAKQVENYITLVNSASLSKQYLKSIVDGVSSRLEEVFAFAKDQKLVKKSIDNFLQLTVNFENLCKTSFNMYFPIFLLPRIEQCIDDSFDGINYVLSYEDYTKETEHERLVVTRLRSVWDRVLLLEQFTPENQLSLRSMACEKAASYIENLILYKIQWNDYGAMALENDISSLITIFSNDQANLRHSFERLQEILILLVWESDSTAPEQLINDLNLQLLSIDIVSAIMEKKANVQGED