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CNTF

Gene
cntF
Protein
Metal-staphylopine import system ATP-binding protein CntF
Organism
Staphylococcus aureus (strain NCTC 8325)
Length
249 amino acids
Function
Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). Involved in the import of divalent metals ions such as nickel, cobalt and zinc. Probably responsible for energy coupling to the transport system (PubMed:23279021, PubMed:29581261). Plays a major role in nickel/cobalt import in zinc-depleted conditions. Contributes to virulence. Required for full urease activity in vitro (PubMed:23279021).
Similarity
Belongs to the ABC transporter superfamily.
Mass
28.18 kDa
Sequence
MIKIKDVEKSYQSAHVFKRRRTPIVKGVSFECPIGATIAIIGESGSGKSTLSRMILGIEKPDKGCVTLNDQPMHKKKVRRHQIGAVFQDYTSSLHPFQTVREILFEVMCQCDGQPKEVMEVQAITLLEEVGLSKAYMDKYPNMLSGGEAQRVAIARAICINPKYILFDEAISSLDMSIQTQILDLLIHLRETRQLSYIFITHDIQAATYLCDQLIIFKNGKIEEQIPTSALHKSDNAYTRELIEKQLSF

Gene
cntF
Protein
Metal-staphylopine import system ATP-binding protein CntF
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Length
249 amino acids
Function
Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). May be involved in the import of a large array of divalent metals ions such as nickel, cobalt, zinc, copper and iron. Probably responsible for energy coupling to the transport system.
Similarity
Belongs to the ABC transporter superfamily.
Mass
28.124 kDa
Sequence
MIKVTDVEKSYQSAHVFKRRRTPIVKGVSFECPIGATIAIIGESGSGKSTLSRMILGIEKPDKGCVTLNDLPMHKKKVRRHQIGAVFQDYTSSLHPFQTVREILFEVMCQCDGQPKEVMEVQAITLLEEVGLSKAYMDKYPNMLSGGEAQRVAIARAICINPKYILFDEAISSLDMSIQTQILDLLIHLRETRQLSYIFITHDIQAATYLCDQLIIFKNGKIEEQIPTSALHKSDNAYTRELIEKQLSF

Gene
CNTF
Protein
Ciliary neurotrophic factor
Organism
Homo sapiens
Length
200 amino acids
Function
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Similarity
Belongs to the CNTF family.
Mass
22.931 kDa
Sequence
MAFTEHSPLTPHRRDLCSRSIWLARKIRSDLTALTESYVKHQGLNKNINLDSADGMPVASTDQWSELTEAERLQENLQAYRTFHVLLARLLEDQQVHFTPTEGDFHQAIHTLLLQVAAFAYQIEELMILLEYKIPRNEADGMPINVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRFISSHQTGIPARGSHYIANNKKM

Gene
CNTF
Protein
Ciliary neurotrophic factor
Organism
Sus scrofa
Length
200 amino acids
Function
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity).
Similarity
Belongs to the CNTF family.
Mass
22.718 kDa
Sequence
MAFAEHSPLTPHRRDLCSRSIWLARKIRSDLTALMEAYVKHQGLNENINLDSVDGVPMASTDRWSELTEAERLQENLRAYRTFHVMLARLLEDQREHFTPAEDDFHQAIHTIVLQVAAFAYQLEELMVLLEHKVPPSEADGTPLSVGGGGLFEKKLWGLKVLQELSQWTVRSIRDLRVISSHQAGVPAHGSHHVAKDKKM

Gene
Cntf
Protein
Ciliary neurotrophic factor
Organism
Rattus norvegicus
Length
200 amino acids
Function
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Similarity
Belongs to the CNTF family.
Mass
22.854 kDa
Sequence
MAFAEQTPLTLHRRDLCSRSIWLARKIRSDLTALMESYVKHQGLNKNINLDSVDGVPVASTDRWSEMTEAERLQENLQAYRTFQGMLTKLLEDQRVHFTPTEGDFHQAIHTLMLQVSAFAYQLEELMVLLEQKIPENEADGMPATVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRVISSHQMGISALESHYGAKDKQM

Gene
CNTF
Protein
Ciliary neurotrophic factor
Organism
Oryctolagus cuniculus
Length
199 amino acids
Function
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Similarity
Belongs to the CNTF family.
Mass
22.662 kDa
Sequence
MAFMEHSALTPHRRELCSRTIWLARKIRSDLTALTESYVKHQGLNKNINLDSVDGVPMASTDQWSELTEAERLQENLQAYRTFHIMLARLLEDQQVHFTPAEGDFHQAIHTLLLQVAAFAYQIEELMVLLECNIPPKDADGTPVIGGDGLFEKKLWGLKVLQELSHWTVRSIHDLRVISCHQTGIPAHGSHYIANDKEM

Gene
Cntf
Protein
Ciliary neurotrophic factor
Organism
Mus musculus
Length
198 amino acids
Function
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Similarity
Belongs to the CNTF family.
Mass
22.587 kDa
Sequence
MAFAEQSPLTLHRRDLCSRSIWLARKIRSDLTALMESYVKHQGLNKNISLDSVDGVPVASTDRWSEMTEAERLQENLQAYRTFQGMLTKLLEDQRVHFTPTEGDFHQAIHTLTLQVSAFAYQLEELMALLEQKVPEKEADGMPVTIGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRVISSHHMGISAHESHYGAKQM

Gene
CNTF
Protein
Ciliary neurotrophic factor
Organism
Gallus gallus
Length
195 amino acids
Function
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Similarity
Belongs to the CNTF family.
Mass
21.33 kDa
Sequence
MAAADTPSATLRHHDLCSRGIRLARKMRSDVTDLLDIYVERQGLDASISVAAVDGVPTAAVERWAEQTGTQRLLDNLAAYRAFRTLLAQMLEEQRELLGDTDAELGPALAAMLLQVSAFVYHLEELLELESRGAPAEEGSEPPAPPRLSLFEQKLRGLRVLRELAQWAVRSVRDLRQLSKHGPGSGAALGLPESQ