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CNGB3

Gene
CNGB3
Protein
Cyclic nucleotide-gated cation channel beta-3
Organism
Homo sapiens
Length
809 amino acids
Function
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
Similarity
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB3 subfamily.
Mass
92.167 kDa
Sequence
MFKSLTKVNKVKPIGENNENEQSSRRNEEGSHPSNQSQQTTAQEENKGEEKSLKTKSTPVTSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQNKPPAAPVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEATPPRKDLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVEEEPHSVRRTVLPRGTSRQSLIISMAPSAEGGEEVLTIEVKEKAKQ

Gene
CNGB3
Protein
Cyclic nucleotide-gated cation channel beta-3
Organism
Canis lupus familiaris
Length
782 amino acids
Function
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity).
Similarity
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB3 subfamily.
Mass
89.424 kDa
Sequence
MFKSLTIKSNKVKPREENDENKQDPDPSNQPQQSTRQGENKSENKSLQTKMTPVTFEESHAKMQDKISEKNSLRDLTTNPNHQHPTESKGAMSEQKEMETGKEGLVSPKSKPLGVPVINEYADAQLHNLVRRMRQRTMLYKKKLAEGDISSPEASPQTAKPTAVPSTQESNAKLKEEHYYHILCFKFQKMPLTEYLKRFRLPGSIDSYTDRLYLLWLLLVTIAYNWNCWLIPLRLVFPYQTPDNTHYWFITDITCDIIYLCDMLLIQPRLQFIKGGDIMVDSNELKRHYRSSTKFQLDVASVMPFDVFYLFFGFNPVFRMNRILKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLYTLHINACIYYWASDYEGIGSTKWVYNGEGNKYLRCYYWAVRTLITIGGLPEPQTSFEIVFQLLNFFSGVFVFSSLIGQMQDVIGAATANQNNFRISMDHTISYMNTYSIPKNVQNRVRTWYEYTWDSQRMLDESDLLCTLPVTMQLALTVDVNLSIISKVELFKGCDTQMIYDMLLRLKSTVYLPGDFVCKKGEIGKEMYIIKQGEVQVLGGSDGAQVLVTLKAGAVFGEISLLAGRGGNRRTANVIAHGFANLLTLDKKTLQEILVHYPDSEKLLMKKASVLLKKKAPATETTPPRKGLAFLFPPKQETPKIFKALLGGTGKAGLTRLLKLKREQTIQKTSENSEEGGGKRREYEDKEREPSEKILDSSECRANCIIAEEMPQSIRRAALPRGTTRQSLIISMAPSAEAGEEVLTIEVKEKAKQ

Gene
Cngb3
Protein
Cyclic nucleotide-gated cation channel beta-3
Organism
Mus musculus
Length
694 amino acids
Function
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3.
Similarity
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB3 subfamily.
Mass
79.722 kDa
Sequence
MLKSLTVKFNKVNPMEGRMEKKLCPNLSSLSQPTIAQGDNQSEKEPLRSRTPITFEKSHSKEDNSTGENSLRDFTPNPDPECRAELTRTMAEMEKTRTGKERPVSFKTKVLETSIINEYTDAHLHNLVERMRERTALYKKTLTEEENFPEVEASSQTAMSTNISPKQENNSKLKEHQDTFSFKPQRVPVKEHLRRMILPRSIDSYTDRVYLLWLLLVTIAYNWNCWLLPVRLVFPCQTPDNKNYWIITDIVCDIIYLCDILLIQPRLQFVRGGEIIVDSNELKRNYRSSTKFRMDVASLLPFEVLYIFFGVNPIFRANRILKYTSFFEFNHHLESIMDKAYVYRVIRTTGYLLFLLHINACVYYWASDYEGIGSTKWVYNGEGNKYLRCFYWAVRTLITIGGLPEPQTSFEIVFQFLNFFSGVFVFSSLIGQMRDVIGAATANQNYFQACMDHIIAYMNKYSIPQSVQYRVRTWLEYTWNSQRILDESNLLENLPTAMQLSIALDINFSIIDKVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGAQVLVTLKAGSVFGEISLLAKGGGNRRTADVVAHGFANLLTLDKKTLQEILLHYPTSKKLLMKKAKILLSQKGKTTQAIPARPGPAFLFPPKEETPRMLKVLLGNTGKVDLGRLLKGKRKTTTQK