Protein
Inosine triphosphate pyrophosphatase
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Function
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Sequence
MTSFVFVTGNANKLREVKAILAAGDSGIEVTSQSVDVPELQGTTQEIAIAKCKVAAEKLGTACVTEDTALCFEALNGLPGPYIKDFLANIGHEGLNTLLNGFPTTRATALCTFAYSPGPGEEPILFEGRTEGNIVPARGSKVFGWDPIFQPLEGGGRTYAEMDGEEKNKISHRYRALEKLRAYLSEQAK