Protein
Tryptophan decarboxylase
Organism
Clostridium sporogenes (strain ATCC 15579)
Function
Catalyzes the decarboxylation of tryptophan to tryptamine. Tryptamine is a neurotransmitter that induces the release of serotonin, which is suggested to modulate gastrointestinal motility. Therefore, the tryptophan decarboxylase from the gut bacteria Clostridium sporogenes (strain ATCC 15579) may influence host brain and behavior. Has weak activity with tyrosine. Activity against phenylalanine is undetectable.
Similarity
Belongs to the group II decarboxylase family.
Sequence
MKFWRKYTQQEMDEKITESLEKTLNYDNTKTIGIPGTKLDDTVFYDDHSFVKHSPYLRTFIQNPNHIGCHTYDKADILFGGTFDIERELIQLLAIDVLNGNDEEFDGYVTQGGTEANIQAMWVYRNYFKKERKAKHEEIAIITSADTHYSAYKGSDLLNIDIIKVPVDFYSRKIQENTLDSIVKEAKEIGKKYFIVISNMGTTMFGSVDDPDLYANIFDKYNLEYKIHVDGAFGGFIYPIDNKECKTDFSNKNVSSITLDGHKMLQAPYGTGIFVSRKNLIHNTLTKEATYIENLDVTLSGSRSGSNAVAIWMVLASYGPYGWMEKINKLRNRTKWLCKQLNDMRIKYYKEDSMNIVTIEEQYVNKEIAEKYFLVPEVHNPTNNWYKIVVMEHVELDILNSLVYDLRKFNKEHLKAM