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CISD2

Gene
CISD2
Protein
CDGSH iron-sulfur domain-containing protein 2
Organism
Bos taurus
Length
135 amino acids
Function
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity).
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
15.278 kDa
Sequence
MVLESVARIVKVQLPAYLKRLPVPESITGFARLTVSEWLRLLPFLGVLALLGYLAVRPFLPKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKKEV

Gene
cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2
Organism
Danio rerio
Length
135 amino acids
Function
Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity).
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
15.485 kDa
Sequence
MVLESISKIIKIQLPAYLKKLPLPETIGGFARLTVSEWLRLLPLLGILALLGYLTIRPFLPKKKKQRDSLINLKIQKENPKVVNEIDIEDLRTPNVCYCRCWRSKTFPVCDKSHIKHNELTGDNVGPLILKKKTL

Gene
CISD2
Protein
CDGSH iron-sulfur domain-containing protein 2
Organism
Homo sapiens
Length
135 amino acids
Function
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
15.278 kDa
Sequence
MVLESVARIVKVQLPAYLKRLPVPESITGFARLTVSEWLRLLPFLGVLALLGYLAVRPFLPKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKKEV

Gene
cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2
Organism
Lithobates catesbeiana
Length
135 amino acids
Function
Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity).
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
15.41 kDa
Sequence
MVLEILARVIKVQLPAYLKRLPVPDSIAGFIRLTVSEWLRLLPFLGVLALLGYLAIRPFLPKKKQQKDSLINLKIQKENPKVVNEIDIEDLRIAKVAYCRCWRSKTFPVCDGSHNKHNELTGDNVGPLILKKKEV

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2
Organism
Mus musculus
Length
135 amino acids
Function
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity).
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
15.242 kDa
Sequence
MVLDSVARIVKVQLPAYLKQLPVPDSITGFARLTVSDWLRLLPFLGVLALLGYLAVRPFFPKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKKEV

Gene
cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2
Organism
Xenopus tropicalis
Length
135 amino acids
Function
Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity).
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
15.35 kDa
Sequence
MVLESIARVIKVQLPAYLKRLPIPDSIAGFIRLTVSEWLRLLPFLGVLALLGYLAIRPFLPKKKQQKDSLINLKIQKENPKVVNEINIEDLHLAKAAYCRCWRSKTFPVCDGSHNKHNELTGDNVGPLILKKKEV

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2 homolog
Organism
Drosophila ananassae
Length
134 amino acids
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
14.71 kDa
Sequence
MESLSQLVKSTLPNYLSNLPIPDSVGGWFKLSFKDWLALIPPTVVVAGIGYTGYLAFCPAAQARCSATKSGRCNNQIRKHEPKVVDTIDVEDIADKAAFCRCWKSKNWPYCDGSHGEHNKLTGDNVGPVVVKKQ

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2 homolog
Organism
Drosophila willistoni
Length
134 amino acids
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
14.822 kDa
Sequence
MESLSHLVKSTLPNYLSNLPVPDTLGGWFKLSFKDWLALIPPTVVVAGIGYTGYLAFCPAAQDRCSAKKNSGRCNNLIRKHEAKVVDMIDVEDIAEKAAFCRCWKTKNWPYCDGSHGEHNKQTGDNVGPVVVKK

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2 homolog
Organism
Drosophila erecta
Length
133 amino acids
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
14.611 kDa
Sequence
MEPISHLVKSSLPNYLSSLPIPDSIGGWFKLSFKDWLALIPPTVVVAGLGYTAYLAYCPAAQGSCSAKKSGRCNNLIRKNEPKVVDMIDVEDIAEKAAFCRCWKTKNWPYCDGSHGEHNKQTGDNVGPIVIKK

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2 homolog
Organism
Drosophila melanogaster
Length
133 amino acids
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
14.633 kDa
Sequence
MEPISHLVKSSLPNYLSSLPVPDSIGGWFKLSFKDWLALIPPTVVVAGLGYTAYLAYCPAARASCAAKNSGRCNNHIRKNEPKVVDMIDVEDIAEKAAFCRCWKTKNWPYCDGSHGEHNKQTGDNVGPIVIKK

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2 homolog
Organism
Drosophila sechellia
Length
133 amino acids
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
14.639 kDa
Sequence
MEPISHLVKSSLPNYLSSLPVPDSIGGWFKLSFKDWLALIPPTVVVAGIGYTAYLAYCPAARASCSAKISGRCNNQIRKNEPKVVDMIDVEDIAEKAAFCRCWKTKNWPYCDGSHGEHNKQTGDNVGPIVIKK

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2 homolog
Organism
Drosophila simulans
Length
133 amino acids
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
14.639 kDa
Sequence
MEPISHLVKSSLPNYLSSLPVPDSIGGWFKLSFKDWLALIPPTVVVAGIGYTAYLAYCPAARASCSAKISGRCNNQIRKNEPKVVDMIDVEDIAEKAAFCRCWKTKNWPYCDGSHGEHNKQTGDNVGPIVIKK

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2 homolog
Organism
Drosophila virilis
Length
133 amino acids
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
14.789 kDa
Sequence
MQSVSQVVKTSLPNYLSSLPVPDTFGGWFKLSFKDWLALIPPTAVVVGIGYVTYRAFYPKAHRTCKSGSGLCNENVRKHEAKVVDMIDIENIADKAAFCRCWKTKNWPYCDGSHAAHNKDTGDNVGPIVIKKK

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2 homolog
Organism
Drosophila yakuba
Length
133 amino acids
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
14.61 kDa
Sequence
MEPISHLVKSSLPNYLSSLPIPDSVGGWFKLSFKDWLALIPPTVVVAGIGYTAYLAYCPAAKAICSAKTSGRCNNLIRKNEPKVVDMIDVEDIAEKAAFCRCWKTKNWPYCDGSHGEHNKQTGDNVGPIVIKK

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2 homolog
Organism
Drosophila grimshawi
Length
132 amino acids
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
14.502 kDa
Sequence
MEPISHLVKSSLPNYLSSLPVPDSLGGWFKLSFKDWLALIPPTAVLAGLGYTAYLAFCPAAQCSAKSARCNNHIRKHEAKVVDMIDVEDIAEKAAFCRCWKTKNWPYCDGSHGEHNKLTGDNVGPVVVSKKK

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2 homolog
Organism
Drosophila persimilis
Length
132 amino acids
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
14.407 kDa
Sequence
MEPISHVVKSSLPNYLSSLPIPDSFGGWFKLSFKDWLALIPPTVVVAGLGYTTYLAFCPAARCAGKDSGRCNSSIRKNEAKVVTMVDVEDIAGQAAFCRCWKTKNWPYCDGSHGEHNKQTGDNVGPVVVKKK

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2 homolog
Organism
Drosophila pseudoobscura pseudoobscura
Length
132 amino acids
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
14.407 kDa
Sequence
MEPISHVVKSSLPNYLSSLPIPDSFGGWFKLSFKDWLALIPPTVVVAGLGYTTYLAFCPAARCAGKDSGRCNSSIRKNEAKVVTMVDVEDIAGQAAFCRCWKTKNWPYCDGSHGEHNKQTGDNVGPVVVKKK

Gene
Cisd2
Protein
CDGSH iron-sulfur domain-containing protein 2 homolog
Organism
Drosophila mojavensis
Length
131 amino acids
Similarity
Belongs to the CISD protein family. CISD2 subfamily.
Mass
14.462 kDa
Sequence
MQSLSHAVKTSLPNYLSSLPVPDSVGGWFKLSFKDWLALIPPTAVVVGIGYISYQALCPAAQRKSCSGRCNDNIRKHEAKVVDMIDIENIADKAAFCRCWKTKNWPYCDGSHGEHNKNTGDNVGPVVIKRN