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CHMP6

Gene
chmp6
Protein
Charged multivesicular body protein 6
Organism
Dictyostelium discoideum
Length
218 amino acids
Function
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
24.947 kDa
Sequence
MGILFSHCSGGREKEDKISKTDRAVLNLKIQRDKLKNYQTQVLEIAIAKECSKAGKKNQALLALKKKKYQEKMLDESFANLQNIEELIANVEQAEIQVRIFESLKQGNESLKEIQKEMSLEDVENLMEETAEAIQYQNDISEALSGKFSKEEEDDLLNELDEMEKQLNAQQYPKVPETQLPKIELPIEDAIEEGKQRKSTTNGLNHILIIACIINHIF

Gene
chmp6
Protein
Charged multivesicular body protein 6
Organism
Danio rerio
Length
206 amino acids
Function
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
23.98 kDa
Sequence
MGNLFGKKKATRVTEQDRAVLQLKQQRDKLKQYQKRITLQMDKERQLAKQLLKDGKKDKALLLLKKKRYQDQLLEKTENQISNLERMVQDIEFAQIEMKVIEGLKVGNDCLKKMHEVLSIEEVEKIMDETHDAIEYQKQIDEMLAGSLTQEDEEAVLAELEAITQGEADLELPEVPGEELPEVPEQEPVREKERVKKKPEREMVAV

Gene
CHMP6
Protein
Charged multivesicular body protein 6
Organism
Homo sapiens
Length
201 amino acids
Function
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.
Similarity
Belongs to the SNF7 family.
Mass
23.485 kDa
Sequence
MGNLFGRKKQSRVTEQDKAILQLKQQRDKLRQYQKRIAQQLERERALARQLLRDGRKERAKLLLKKKRYQEQLLDRTENQISSLEAMVQSIEFTQIEMKVMEGLQFGNECLNKMHQVMSIEEVERILDETQEAVEYQRQIDELLAGSFTQEDEDAILEELSAITQEQIELPEVPSEPLPEKIPENVPVKARPRQAELVAAS

Gene
CHMP6
Protein
Charged multivesicular body protein 6
Organism
Pongo abelii
Length
201 amino acids
Function
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membrane (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
23.486 kDa
Sequence
MGNLFGRKKQSRVTEQDKAILQLKQQRDKLRQYQKRIAQQLERERALARQLLRDGRKERAKLLLKKKRYQEQLLDRTENQISSLEAMVQSIEFTQIEMKVMEGLQFGNECLNKMHQVMSIEEVERILDETQEAVEYQRQIDELLAGSFTQEDEDAILEELSAITQEQIELPEVPSEPLPEKIPEDVPVKARPRQAELVAAS

Gene
CHMP6
Protein
Charged multivesicular body protein 6
Organism
Gallus gallus
Length
200 amino acids
Function
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
23.259 kDa
Sequence
MGNLFGRKRRSRVTEQDKAVLQLKQQRDKLRQYQKRISLGLERERELARQLLKEGKKEKAMLLLKKKRYQEQLLDKTDNQISNLERMVQDIEFTQIEMKVIEGLKIGNECLNKMHQVMSIEEVERIIGETQDAVEYQRQIDEILAGSLTEEDEDAILEELNAITQEQLELPDVPSEPLPEEPPEATPVKNRPKPELVAAS

Gene
Chmp6
Protein
Charged multivesicular body protein 6
Organism
Mus musculus
Length
200 amino acids
Function
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity).
Similarity
Belongs to the SNF7 family.
Mass
23.416 kDa
Sequence
MGNLFGRKKQSRVTEQDRAILQLKQQRDKLRQYQKRVTQQLERERALARQLLRDGRKERAKLLLKKKRYREQLLDRTENQISSLEAMVQSIEFTQIEMKVMEGLQVGNECLNKMHQVMSIEEVERILDETQEAVEYQRQIDELLAGNFTQEDEDAILEELNAITQEQMELPEVPSEPLPDRNPEAPAKARSRQAELVAAS