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CHK1

Gene
CHK1
Protein
Histidine protein kinase 1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
2471 amino acids
Function
Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan and glucan biosynthesis. Regulates quorum sensing as well as hyphal formation, biofilm formation, chlamidospore formation, and virulence. Plays a prominent role in phagocyte activation. Involved in the covering of the most potent proinflammatory cell wall molecules, the beta-glucans, underneath a dense mannan layer, so that the pathogen becomes partly invisible for immune cells such as phagocytes.
Mass
281.795 kDa
Sequence
MSMNFFNSSEPARDHKPDQEKETVMTTEHYEFERPDVKAIRNFKFFRSDETETKKGPNLHISDLSPLESQSVPPSALSLNHSIIPDQYERRQDTPDPIHTPEISLSDYLYDQTLSPQGFDNSRENFNIHKTIASLFEDNSSVVSQESTDDTKTTLSSETCDSFSLNNASYLTNINFVQNHLQYLSQNVLGNRTSNSLPPSSSSQIDFDASNLTPDSIPGYILNKKLGSVHQSTDSVYNAIKIPQNEEYNCCTKASASQNPTNLNSKVIVRLSPNIFQNLSLSRFLNEWYILSGKHSSKEHQIWSNESLTNEYVQDKTIPTFDKESARFRPTLPINIPGILYPQEIINFCVNSHDYPLEHPSQSTDQKRFAMVYQDNDYKTFKELSMFTLHELQTRQGSYSSNESRRKSSSGFNIGVNATTTEAGSLESFSNLMQNHHLGATSTNGDPFHSKLAKFEYGVSKSPMKLIEILTDIMRVVETISVIHELGFVHNGLTSSNLLKSEKNVRDIKITGWGFAFSFTENCSQGYRNKHLAQVQDLIPYMAPEVLAITNSVVDYRSDFYSLGVIMYELVLGILPFKNSNPQKLIRMHTFENPIAPSALAPGWISEKLSGVIMKLLEKHPHNRYTDCHSLLHDLIEVKNMYISKLLDSGETIPNSNLNLSDRQYYLTKENLLHPEKMGITPVLGLKESFIGRRDFLQNVTEVYNNSKNGIDLLFISGESGRGKTIILQDLRAAAVLKQDFYYSWKFSFFGADTHVYRFLVEGVQKIITQILNSSEEIQNTWRDVILTHIPIDLSILFYLIPELKVLLGKKYTSIYKHKIGMGMLKRSFKEDQTSRLEIKLRQILKEFFKLVAKQGLSIFLDDVQWCSEESWRLLCDVLDFDSSGEVRESYNIKIVVCYALNADHLENVNIEHKKISFCRYAKQSHLNLREFSIPHIPLEDAIEFLCEPYTRSHDHECNSKKSDVIANLNCTNEYPQNTCKVIPSIIQELYQSSEGNVLLLIFLTRMTKLSGKVPFQRFSVKNSYLYDHLSNSNYGTTRKEILTNYLNMGTNSDTRALLKVAALISNGSGFFFSDLIVATDLPMAEAFQLLQICIHSRIIVPTSTYYKIPMDLIASDQTPFDLTDDNIWKLATLCSYKFYHDSICTHIIKELNASGEFKELSRLCGLRFYNTITKERLLNIGGYLQMATHFRNSYEVAGPEENEKYVEVLVQAGRYAISTYNMKLSQWFFNVVGELVYNLDSKTQLKSVLTIAENHFNSREFEQCLSVVENAQRKFGFDRLIFSIQIVRCKIELGDYDEAHRIAIECLKELGVPLDDDDEYTSENSLETCLGKIPLSVADIRGILKIKRCKNSRTLLMYQLISELIVLFKLQGKDKVRRFLTAYAMSQIHTQGSSPYCAVILIDFAQSFVNETTTSGMLKAKELSIVMLSLINRAPEISLSYVQSIYEYYFSCHAVFFESIEKMSDLIHPGNASSHCTRSSYYSSFHLIVNVSKIFFSCMNGESFKMFSTFKCKSYLTGDPQMPEMDNFLYDSEMLLAGHSELNEFMRKYQSFNQTSVGKFCYYLIVLLVMSREHRFDEAADLVLKVLEDLSEKLPVSFLHHQYYLICGKVFAYHQTKTPESEEQVERILARQFERYELWASTNKPTLLPRYLLLSTYKQIRENHVDKLEILDSFEEALQTAHKFHNVYDMCWINLECARWLISINQKRHRISRMVKQGLKILRSLELNNHLRLAEFEFDEYIEDEDHRNKWAGLTNNPTLDTVTTWQQQNMPDKVSPCNDKQLVHGKQFGKKEFDSHLLRLHFDGQYTGLDLNSAIRECLAISEALDENSILTKLMASAIKYSGATYGVIVTKKNQETPFLRTIGSQHNIHTLNNMPISDDICPAQLIRHVLHTGETVNKAHDHIGFANKFENEYFQTTDKKYSVVCLPLKSSLGLFGALYLEGSDGDFGHEDLFNERKCDLLQLFCTQAAVALGKERLLLQMELAKMAAEDATDEKASFLANMSHEIRTPFNSLLSFAIFLLDTKLDSTQREYVEAIQSSAMITLNIIDGILAFSKIEHGSFTLENAPFSLNDCIETAIQVSGETILNDQIELVFCNNCPEIEFVVGDLTRFRQIVINLVGNAIKFTTKGHVLISCDSRKITDDRFEINVSVEDSGIGISKKSQNKVFGAFSQVDGSARREYGGSGLGLAISKKLTELMGGTIRFESEEGIGTTFYVSVIMDAKEYSSPPFSLNKKCLIYSQHCLTAKSISNMLNYFGSTVKVTNQKSEFSTSVQANDIIFVDRGMEPDVSCKTKVIPIDPKPFKRNKLISILKEQPSLPTKVFGNNKSNLSKQYPLRILLAEDNLLNYKVCLKHLDKLGYKADHAKDGVVVLDKCKELLEKDEKYDVILMDIQMPRKDGITATRDLKTLFHTQKKESWLPVIVALTANVAGDDKKRCLEEGMFDFITKPILPDELRRILTKVGETVNM

Gene
CHK1
Protein
Serine/threonine-protein kinase CHK1
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
662 amino acids
Function
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles (By similarity).
Similarity
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
Mass
72.566 kDa
Sequence
MTIPKSSTGQSYPPVLDYRIVQLIGGGGFSKVFRAVNPSSESHSVAAIKVISYAPNRSNKYPIDRRALQKEVQVHSILKHPNVLEFLGAVERGVDKNGNAGKEKGILMGEAVATTKESIRARDKERQQMLSSPSHDQNYVPGLYMVLELGAGGDLFDKIAPDYGVEEDLAHFYFQQLLAGLEYIHSQGVTHRDIKPENMLLDAEGNLKIADFGLCSVYKYKGKERELTGACGSLPYIAPEMNGKPYRGEPVDVWSSGVVLFAMLVGSTPWDEPTSRSPEYSAYRTGKLFEYDPWPRIPQDALSLLKKMMHPTPEKRITFEGIRRHRWFKRANDLMTQKGKCNDPVNLAEKLLQGLAVSGDIIVEVNGAAAAAARRLDLHSDGQRAQVPENVSLTQPDAILTSSFDLAARAVARGWADDTGPGGGLPLPSSTAMPAFASDDMSRRLAMSQHISSRRAEFSTTASGSGYDMALPGASQFTQALNHFTQFEALTHVAGTGSSHLRFSPHLTRFFSSASAATILALIIDVLDRLAVLNAHQAIGDQEELELEEAYNFMADGEPETTVPSDDSSRPTGGSKRLLIGSRGARIRLKTMDRRKCVLRGEVYVENLAAPDSTSDSASAPDRNAAKCLVVMKKGKGDPLEWRRLFREVCRRPEIMQTIIST

Gene
CHK1
Protein
Serine/threonine-protein kinase CHK1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
527 amino acids
Function
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Controls phosphorylation and abundance of PDS1 to prevent anaphase entry. Also helps prevent mitotic exit.
Similarity
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
Mass
60.017 kDa
Sequence
MSLSQVSPLPHIKDVVLGDTVGQGAFACVKNAHLQMDPSIILAVKFIHVPTCKKMGLSDKDITKEVVLQSKCSKHPNVLRLIDCNVSKEYMWIILEMADGGDLFDKIEPDVGVDSDVAQFYFQQLVSAINYLHVECGVAHRDIKPENILLDKNGNLKLADFGLASQFRRKDGTLRVSMDQRGSPPYMAPEVLYSEEGYYADRTDIWSIGILLFVLLTGQTPWELPSLENEDFVFFIENDGNLNWGPWSKIEFTHLNLLRKILQPDPNKRVTLKALKLHPWVLRRASFSGDDGLCNDPELLAKKLFSHLKVSLSNENYLKFTQDTNSNNRYISTQPIGNELAELEHDSMHFQTVSNTQRAFTSYDSNTNYNSGTGMTQEAKWTQFISYDIAALQFHSDENDCNELVKRHLQFNPNKLTKFYTLQPMDVLLPILEKALNLSQIRVKPDLFANFERLCELLGYDNVFPLIINIKTKSNGGYQLCGSISIIKIEEELKSVGFERKTGDPLEWRRLFKKISTICRDIILIPN

Gene
chk1
Protein
Serine/threonine-protein kinase chk1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
496 amino acids
Function
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:8497322). May also negatively regulate cell cycle progression during unperturbed cell cycles. Binds to and phosphorylates CDC25. This leads to negative regulation of CDC25 and prevents mitotic entry (PubMed:9278510).
Similarity
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
Mass
56.506 kDa
Sequence
MAQKLDNFPYHIGREIGTGAFASVRLCYDDNAKIYAVKFVNKKHATSCMNAGVWARRMASEIQLHKLCNGHKNIIHFYNTAENPQWRWVVLEFAQGGDLFDKIEPDVGIDEDVAQFYFAQLMEGISFMHSKGVAHRDLKPENILLDYNGNLKISDFGFASLFSYKGKSRLLNSPVGSPPYAAPEITQQYDGSKVDVWSCGIILFALLLGNTPWDEAISNTGDYLLYKKQCERPSYHPWNLLSPGAYSIITGMLRSDPFKRYSVKHVVQHPWLTSSTPFRTKNGNCADPVALASRLMLKLRIDLDKPRLASSRASQNDSGFSMTQPAFKKNDQKELDRVEVYGALSQPVQLNKNIDVTEILEKDPSLSQFCENEGFIKRLAKKAKNFYEICPPERLTRFYSRASRETIIDHLYDSLRLLAISVTMKYVRNQTILYVNLHDKRKCLLQGVIELTNLGHNLELINFIKRNGDPLEWRKFFKNVVSSIGKPIVLTDVSQN

Gene
CHK1
Protein
Probable serine/threonine-protein kinase CHK1 homolog
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
414 amino acids
Function
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles (By similarity).
Similarity
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
Mass
46.023 kDa
Sequence
MPKYELQETLASGSTSKVKRAAAPGNAKCVVKVIRKKDVPLRVFLREVKIHRSLRHPNIVGFVDSYEDCHGYCIVMKLGCGEVGSMIRAGGGLDPLLAHFYFRQLVSAVEYLHGKCICHRDIKPENMLIDSAGNLLLSDFGFSTVFFHKGRRRRLRSPAGSLEYMAPEVFEGAYDGELADVWSCGVSLVVFLTGALPWDRAVESDERFSAFVSSRGGCQVPLSSIGDQAMGLVMRMTAKEDRRPSVSTVMKDPWVMQPNELLDESGLCRDSCRLFSLVPRQTGSALHFTQPGEVHKTPRTRPVSSQPRRAGSGDICRVYIGEESLRLALRRVCEALDGMVVSHRIAKEHVMFSTVDSRRSVLSGEVGVIRLDEGCCMTIRRAKGDPQEFKRFTRVLAESLGCNGRKCTILYNEI