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CHCHD3

Gene
CHCHD3
Protein
MICOS complex subunit MIC19
Organism
Bos taurus
Length
227 amino acids
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.
Similarity
Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic19 subfamily.
Mass
26.1 kDa
Sequence
MGGTASTRRVTFEADENENITVVKGIRLSENVIDRMKETSPSGPKSQRYSGTYGASVSDEELKRRVAEELALEQAKKESENQKRLKQSKELDAEKAFANEQLTRAILRERISNEEERAKAKHLAKQLEEKDRVIKKQDAFYKEQLARLEERSSEFYKVTTEQYQKAAEEVEAKFKRYEYHPVCADLQAQILQCYRQNTQQTLSCSALASQYMRCVNQAKQSTLEKGG

Gene
CHCHD3
Protein
MICOS complex subunit MIC19
Organism
Homo sapiens
Length
227 amino acids
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180).
Similarity
Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic19 subfamily.
Mass
26.152 kDa
Sequence
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDEELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKAKHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG

Gene
Chchd3
Protein
MICOS complex subunit Mic19
Organism
Mus musculus
Length
227 amino acids
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.
Similarity
Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic19 subfamily.
Mass
26.335 kDa
Sequence
MGGTASTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSSVYGASVSDEDLKRRVAEELALEQAKKESEHQRRLKQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLARQLEEKDRVMRKQDAFYKEQLARLEERSSEFYKVTTEEYQKAAEEVEAKFKRYEYHPVCADLQTKILQCYRQNTQQTLSCSALASQYMHCVNHAKQSMLEKGG