CHAF1A

Chromatin assembly factor 1 subunit A

964 amino acids

Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.

Belongs to the CHAF1A family.

107.258 kDa

MLEEPECGAPGARGEAAAMDCKDRPAFPVKKLIQARLPFKRLNLVPKEKIDDGLDDTGGSRAGPVQTQLHNLETSLDHLENCHMGSDIDFRPKLVNGKGPLDNFLRSQVETSIGQAVVIIDLTEDSSNPPDNMVGHNKLNSAASSAQKNINGVPDKAGDDRGLPKARQKDELASPEEALSEVPCKTEAGGADSGGADRRGLTQRGSPQNCPKLTGDLSMWSEKDRDGWSEAGGILFKGKMPVVVLQDILALRPPARSPPATPPSQAVPSESETPESSPEEDLALSHSSLSSSSPTSSPEGQSVPTKLHTGPSPFPASTPVCRITKKLVRGSAEKNKMKLQRDKERLRRQLKLRAEKEEKEKLREEAKRAKEEARKKREEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRCRTAFDQDLCDQLDQLLQQQSSEFSFLQDLKSRRPLRSGPTVVSNRNTDLSNSDVVIVESSKVDGVPERRKFGRMKLLQFSENHRPAYWGTWNKKTTVIRPRDPWAQDRDLLDYEVDSDEEWEEEEPGESLSHSEGDDDDDVGEDEDEDDGFFVPHGYLSEDEGVTEECADPENHKVRQKLKAKEWDEFLAKGKRFRILQPVKIGCIWAADKDGGADLKVLQQFTACLLETVPPEEEQTPKASKREKRDQQILAQLLPLLHGNVNGSKVIIREFQECCRRGLLSRDAGSPEDSAASPPSPGPARPQTPTASEDVAVPSKARLKRIISENSVYEKRPDFRMCWYVHPQVLKSFAQEHLPVPCQWSYVTAVPSATREDSGSVPAPGPGQGMPVSLKRKSAGSMCITQFMKKRRHDGQVGTGDLDDFQADTEEEDDDEGDCVIMDISDVGDIQAPCGTTSGAGGSVGMDTSESFVSPSSLRLS

CHAF1A

Chromatin assembly factor 1 subunit A

956 amino acids

Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity).

Belongs to the CHAF1A family.

106.91 kDa

MLEELECGAPGARGAATAMDCKDRPAFPVKKLIQARLPFKRLNLVPKGKADDMSDDQGTSVQSKSPDLEASLDTLENNCHVGSDIDFRPKLVNGKGPLDNFLRNRIETSIGQSTVIIDLTEDSNEQPDSLVDHNKLNSEASPSREAINGQREDTGDQQGLLKAIQNDKLAFPGETLSDIPCKTEEEGVGCGGAGRRGDSQECSPRSCPELTSGPRMCPRKEQDSWSEAGGILFKGKVPMVVLQDILAVRPPQIKSLPATPQGKNMTPESEVLESFPEEDSVLSHSSLSSPSSTSSPEGPPAPPKQHSSTSPFPTSTPLRRITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNSDVVIVERGKGDGVPERRKFGRMKLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEVDSDEEWEEEEPGESLSHSEGDDDDDMGEDEDEDDGFFVPHGYLSEDEGVTEECADPENHKVRQKLKAKEWDEFLAKGKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLETLPAQEEQTPKASKRERRDEQILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTYLHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHPQVLQSFQQEHLPVPCQWSYVTSVPSAPKEDSGSVPSTGPSQGTPISLKRKSAGSMCITQFMKKRRHDGQIGAEDMDGFQADTEEEEEEEGDCMIVDVPDAAEVQAPCGAASGAGGGVGVDTGKATLTASPLGAS

CHAF1A

Chromatin assembly factor 1 subunit A

937 amino acids

Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Involved in rapid nucleosome formation during DNA replication (PubMed:17065558).

Belongs to the CHAF1A family.

105.133 kDa

MAAMECRDKAVVPPRRLVQARLPFKRLNPVPKEKHDAEAEGKKGKCSKSGLGQSKDSSTDTLHASTDNMENDCQLNSDVNFVPKLVNGKGPLDHFIQKSTKDNTDEIIVIIDSVDESNQRLSDDVDHVSFDSKASSAALTNGMLGKDMNKLSCLNSTQNSQTDDSMQTDVPCEAIANKGEDLVDGIQSCSGLTERNNLENTKVNQSELKDVIFEGKMPVVLLEDIMAAKSPQVTSLDGSVTSENETVELSHEGDSVLTNSSLSSLSVSSPEAQPVAETKRNTSPLAVSTPVRKVSQKLHKSSAEKEKLRLQRDQERADKLQKLQAEREEKGRLKEEAKAAKERAKEEAKKKKEEEKELKERERREKKEKEEKEKAEKLRVKEEKRKERQEALEAKLEEKRKKEEEKRLKEEEKRINAQKAEITRFFQKPKTPQAPKILAGSCGKFAPFEIKENMVLAPLCRIALYPDFLEQLDRLLRAQNSEVSFLRDLKCRKPRKTGPTFVNSSTDTVNSDVVVVDNCKTDAVPERGKFGRMKLLQFCENHRPAYWGTWNKKTTMIRPRNPWSKDSKLLDYEVDSDEEWEEEEPGESLSHSEGDDEEEGEDEDDDDGFFIPHGYLSEDEGVTEECDPENQKVRQKLKAKEWDELMAKGKRLHVLQPVKIGCIWESAQNDSGTNADLKILQQFTACILDSSVAEEEQQIQKCSKKRAKDQQILGQLLPLLHGNVNGSKVIIQEFQECCRQGLFSDVTAATDCGDTSPVSPNTSRPQTPVGEDSGVPSKARLKRIISENSVYEKRPEYRMCWYVHSEVLKSFDQEHLPVPCQWNYITQVPSSGKEDGGSVPGVAPVQSTPVSVKRKSTGSMCITKFMKRPRDAEQAEAMEMDGFQADTEEDEDDDDCMIVDVQPCKDSTLTVTETAPESRGTTAAHQDASMVSPSNTV

Chaf1a

Chromatin assembly factor 1 subunit A

911 amino acids

Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.

Belongs to the CHAF1A family.

101.936 kDa

MLEEPEAATRTAAAVDCKDRPGFPVKRLIQARLPFKRLNLVPKEKVEEDTSPKAAVESKVPDLQLSLGTFESQCHTGSHVGLSTKLVGGQGPIDSFLRATIKPVPSVVIIDLTENCSDIPDSPEGHSELSPDTAGVVTTVEGAAKQQEHSAAELCLLETPSDITCHMEEEPGSPGDPKRTGDCQAGSLQSCPELTPGSRTCPTKELSSWSKAGDLLFIEKVPVVVLEDILATKPSIASLPMMSLDRSVTSESEILESCPEDDSILSHSSTNSSSPTSSPEGPSTPPEHRGGRSSPSTPACRVAKNFVKGSTEKGRSKLHRDREQQREEKEKLREEIRRAKEEARKKKEEEKELKEKERREKREKDEKEKAEKQRLKEEKRKERQEALEAKLEEKRKKEEEKRLREEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRCRAALDQDLCDQLDQLLQQQSVASTFLSDLKSRLPLRSGPTRVCGHDTDIMNRDVVIVESSKVDGVSERKKFGRMKLLQFSENHRPAYWGTWNKKTAIIRPRNPWAQDKDLLDYEVDSDDEWEEEEPGESLSHSEGDEDDDVGEDEDEDDGFFVPHGYLSEDEGVTEECADPENHKVHQKLKAKEWDELLAKGKRFRVLQPVHVGCVWASEAANCTSSDLKLLQQFTACLLDVASPDEPEPGASRREKRDQHILAQLLPLLHGNVNGSKVIIHEFQEQCRRGLLTLPSPTPHLQMPNLEDAVAVPSKARLKRLISENSAYEKRPNFRMCWYVHPEVLKSFGQECLPVPCQWTYITTMPSAPREDSGSASTEGPGQSTPMLLKRKPAATMCITQFMKKRRYDGQVGSGDMDGFQADTEEDEEDDTDCMIIDVPDVGSDVSEAPIPAPTLCK

chaf1a

Chromatin assembly factor 1 subunit A

863 amino acids

May be involved in chromatin assembly in DNA replication and DNA repair.

Belongs to the CHAF1A family.

97.223 kDa

MVVVMLAAEEPLASTPRRDMDCVGKANTNKKLVQARLPFKRLNPEPKECNEPKRTKGPVAPKCSEPSDQENDQDSSSISHHGPALVNGRGPLDCFMSRRKRSPLRSAPEATIDLTEDSNDSAKQQPAPPIAATCPLSEEKTKTSEGTTEPTIPLTEEETEKDEAEDVDALPLLDITQDSDTEEEEEEEEEEEEQQQEAEVSHGNESVLSTGSTSSASVIASSPEPSKSAPTTPASTSRINAANKVKRRSLKSVQEQEEKQRQRDEKERLKQEAKAAKEKKKEEARKMKEEKEREKKEKKEKDEKERREKKERDEKEKADKLKAKEEQRQMKIEAKLEEKRKKEEEKRLKEEKDRIKAEKAEITRFLQKPKTQLAPKTLASACGKFAPFEIKAHMSLAPLTRVQCEDSVLEDLDRYLAQPDSTLNGLKDWTGHKPRSSGPTRPRHSAQGDCVVITESQKADDGPDRSRYGRMKLLHFHDNYRPAYWGTWSKKSTHISPRCPLRLDKDLLDYEVDSDEEWEEEEPGESLSHSEGDDDDEAGEDDDDDDGFFVPHGYLSEGEGALEDEEGGDPEKQKVRQRMKAREWENELMSKGKVKVLEAVVRGCFWEGEKPLPDFLQPYAVCMLEPLSKDEASTPEQDASRQQRNEKLLTMLLPLLHGNVNSNKVIITEFLEFCRQQTSSPTESLLNTTESIPPRIHVRRIIKENAVYEKRSTFKRCCWYVHADVLARYSQEALPVPCQWSYLTSGANVTRDEHSGSQGNSPTTNSSTTPSNKRKSASSHSITKYMKKCGESEQTEAMETDGFQADTEDDEDDDCIIIGEQSGSSEQDINTSLPQTDRETEPMDTSASETAALALPCPTPATA