CGN

Gene

cgn

Protein

Cingulin

Organism

Xenopus laevis

Length

1360 amino acids

Function

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier, possibly by linking ZO proteins to the actomyosin cytoskeleton.

Similarity

Belongs to the cingulin family.

Mass

158.466 kDa

Sequence

MADQHIPVGQGVQIRFIGDLKENGKPRGKRSKQDSYGVAVRVQGIDGQPFVVLNSGDKAKSSFGVQIKSQEPYLNASNTSPPNYQNYSSKPRGPSRSISSESELPENPYGSRGYRPSSSHYSSASDEEQKPRGNIRGSDGLSSLPRPLQASRREELRRSQSHSSLLEPDVEESYDYDHHYSERSSTLDTTYSQSSRDSAWSRSSQKKIDNGDYPSLGYRSATSQQSTSVSNKTKKNGLSTSSPSNQSNEDIDTKPLSSVDSLINKFDIKGQVRGRTARRSQALKDERKRSQSLDGRKNYHDTADSREIIVEKQNEVQTMREPVNASNRSFNRQTLERGDISKTRLTKEWLDQDREEPVILKQQRTVQSEFQLKSTPDLLRDQQPDGSDPTREMIFGILREGSLESENTLRKKTSILLEKLPSLQVQPGEDTISLGSQKKELERKVAELQRQLDDEMKQRMKLETSQGRPKAGMQRLEIELEESKEECSRLKELYEKKKNELSAMSQELMEVRMGKEQVETKLRTMEDKLMDSKEELSHLRAKGGTSPDKLALLKELEEVQDELDEVLQIRQKQEELLRQKDRELTALKGALKDEVANHDKDLDRVREQYQNDMQQLRKNMDNVSQDQLSLESERQKINQVVRNLQRELEESSDEISQWKEMFQKNKEELRSTKQELLQMKLEKEESEDELKETRDRFSLLQSELAQVKKGSVDPGEVASVRKELQRVQDQLKQLSVDKQKVEENLQQREREMSALKGTLKEEVSGRDRETVRLREQLQSEVMHVKKENEGLAKESRRIQDQLKQVLLEKQRHEETVHQRERELSVLKGALKDEVSGRDRETEKLRERLEQDALMTKRSYEELVKINKRLESEKTDLERVRQVIENNLQESREENDDLRRKILGLEAQLKETNTFCDDLQRAESRLKDKINKLEAERKRMEDSLGEVADQEQELAFVKRDLESKLDEAQRSLKRLSLEYEELQECYQEEMKQKDHLKKTKNELEEQKRLLDKSMDKLTRELDNMSNESRGSLQLLQTQLEEYREKSRKEIGEAQKQAKEKTAEAERHQFNSSRMQEEVQKLKLALQELQVEKETVELDKQMISQRLQSLEQDIESKKRVQDDRSRQVKVLEDKLKRMEAELDEEKNTVELLTDRVNRSRDQMEQQRAELNQERSRGQDLECDKISLERQNKELKNRLASMEGQQKPSVNVSHLEAKLQEIQERLQLEEREKATLLSTNRKLERKLKELNIQLEDERLQVNDQKDQLNLRVKALKRQVDEAEEEIERLEGLRKKAVREMEEQQEINEQLQTRVKVMEKESKRKPIRPAHDDDLSSDGEFGGPYDPSSITSLLTESNLQTSSC

Protein

Cingulin: cgn

Gene

cgn

Protein

Cingulin

Organism

Xenopus tropicalis

Length

1251 amino acids

Function

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier, possibly by linking ZO proteins to the actomyosin cytoskeleton.

Similarity

Belongs to the cingulin family.

Mass

145.959 kDa

Sequence

MADQPIPVGQGVQIRFINDLKENGKPRGKRSKQDSYGVAVRVQGIDGQPFVVLNSGDKAKSSYDYDRHYSERSSTLDTAYSQSSRESAWSRGSQKKTDNGEYPSLGYRSATSQQSTSASNKTNKNGLSTSSFSNQSSEDIDTKPLSSVDSLITKFDVKGQVRGRTARRSQALKDERKRSQSLDGRKNYQDTADSREISLQQQNEVPARRETVSSANRSFARQSLEREDINKTRLTKEWLDQGGEEPVIVKQQRSVQSEFQLKSTPDLLRDQQADGSDPTREMIFSILRDGSTENENNLRKKTSILLEKFPSLQAQPGEDTRSLGSQKKELERKVAELQRQLDDEMKQRMKLESSQGRPKAGMQRLEIQLEESKEECSRLKDLYDKKKNELNAVSQELMEVRMGKEQVETKLRAMEDKLMDSKEELSHLRAKGGTSPDKLALMKELEEVQDELDEVLQIRQKQEELLRQKDRELTALKGALKDEVANHDKDLDRVREQYQNDVQQLRKNMENVSQDQLSLETERQKINQVVRNLQRELEESSDEINQWKEMFQKNKEELRSTKQELLQMKMEKEESEDELKETKDRFSLLQSELEQAKKGSVDPGELASVRKELQRVQDQLKQLSVDKQKVEENLHQRERELSALKGALKEEVAGRGRETERLREQLQSEVVQFKKDNENLGRESQRIQDQLKQVLLEKQRHEEAVHQRERELSALKGALKDEVSGRDREAERLRAQFEQDAMQTKRSYEELVKINKRLESEKVDLERVRQVIENNLQESREENDDLRRKILGLEAQLKETNTFCDDLQRAESRLKDKITKLETERKRMEDTLGEAADQEQELAFVKRDLGNKLEEAQRSLKRLSLEYEELQECYQEEMKQKDHLKKTKNELEEQKRLLDKSMDKLTRELDNMSNESRGSLQVLQSQLEEFREKSRREIGEAQKQAKEKTAEAERHQFNSSRMQEEVQKLKLALQELQVEKETVELDKQMVTQRLQNLEQDTESKKRVQDDRSRQVKVLEDKLKRMEAELDEEKNTVELLSDRINRSREQMEQQRAELMQERARGQDLECDKISLERQNKDLKGRLANMEGQQKPSVNVSHLEAKLQDIQERLQSEEREKATLLSTNRKLERKLKELNIQLEDERLHVNDQKDQLNLRVKALKRQVDEAEEEIERLEGLRKKAVREMEEQQELNEQLQTRLKTMEKESKRKPIRPAHNDDDDLSSDGEYGGSYDPSSITSLLTESNLQTSSC

Protein

Cingulin: cgn

Gene

CGN

Protein

Cingulin

Organism

Callithrix jacchus

Length

1198 amino acids

Function

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Similarity

Belongs to the cingulin family.

Mass

136.144 kDa

Sequence

MAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGIAGQPFVVLNSGEKGGDSFGVQIKGANDQGASGALSSDSELPENPYSQVRGFPAPSQSSTSDEDPGTQWNGKLLRSQSQASLAGPGPMDPSNRSTSMLDLAPKAASPGSTIDTAPLSSVDSLINKFDSQLRGQARGRTGHRTRMLPPEQRKRSKSLDSRLPRDTLEERERQSTNHWNPNTKYDNHVGSSKQPAQSPSPSPSPLSGLSRARQTQDWVLQSFEEPQGRAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMMSSGSSKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSRVGLERQLEEKTEECSQLQELLERRKGEAQQSNKELQNMKRLLDQGESLRHGLETQVVELQNKLKQVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQCQRDTEQLRKSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEELRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKLCQTQEELKELQAERQSQEVAGRHRDRELEKQLSVLRVEADRGRELEEQNFQLQKTLQQLRQNCEEASKAKMVAEAEAAVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRSKAELEEQKRLLDKTVDRLNKELEQIGEASKQALQQLQSQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLNRLQDEIQRLRQALQACQAERDTAQLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLEAELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQRELEEQHEVNEQLQARIKSLEKDSWRKASRSAAESTLKHEGLSSDEEFDGVYDPSSIASLLTESNLQTSSC

Protein

Cingulin: CGN

Gene

CGN

Protein

Cingulin

Organism

Plecturocebus moloch

Length

1198 amino acids

Function

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Similarity

Belongs to the cingulin family.

Mass

135.574 kDa

Sequence

MAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGIAGQPFVVLNSGEKGGDSFGVQIKGASDQGASGALSSDSELPENPYSQVQGFPAPSQSSTSDEDPGAQWNGKLLRSQSQASLAGPGPVDPSNRSTSMLDLAPKVASPGSTIDTAPLSSVDSLINKFDGQLGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTLEERERQSTNHWNPSTKYNNHVGSLKQPAQSPSPSPLSGFSRARQTQDWVLQSFEEPRGRAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESEASVRRKVSLVLEKMQPLGVISSGSSKAMAGQGELARKVEELQRKLDDEVKKRQKLEPSRAGLERQLEEKTEECSQLQELLERREGEAQQSSKELQNMKRLLDQGESLQHGLETQVMELQSKLKQVQGPEPAKELLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQCQRDTEQLRKSMQDASQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEELRATKQELLQLRMEKEEMEEELGEKIEALQRELEQARASAGDARQVEVLKKELRRAQEELEELQAERQSQEVAGRHRDRELEKQLAGLRVEADRGRELEEQNFQLQKTLQQLRHDCEEASKARGMAAEAEATVLGQRRGAVEAALRETQGDNDELRRRVLGLEQQLRETRGLVDGGEAAEARLRDKLQRLEADKQRLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLTRALEEEGKQREALRRSKAELEEQKRLLDRTVDRLNEELEQIGEASKQALQQLQAQLEEYKEKARREVADAQRQAKDWASEAEKSSGGLNRLQDEIQRLRQALQACQAERDTAQLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLEAELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKAFFRQVDEAEEEIERLDSLRRKAQRELEEQHEVNGQLQARVKSLEKDSWRKASRSAAESALKHEGLSSDEEFDSVYDPSSIASLLTESNLQTSSC

Protein

Cingulin: CGN

Gene

CGN

Protein

Cingulin

Organism

Homo sapiens

Length

1197 amino acids

Function

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Similarity

Belongs to the cingulin family.

Mass

136.386 kDa

Sequence

MAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGIAGQPFVVLNSGEKGGDSFGVQIKGANDQGASGALSSDLELPENPYSQVKGFPAPSQSSTSDEEPGAYWNGKLLRSHSQASLAGPGPVDPSNRSNSMLELAPKVASPGSTIDTAPLSSVDSLINKFDSQLGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESNLQTSSC

Protein

Cingulin: CGN

Gene

CGN

Protein

Cingulin

Organism

Papio anubis

Length

1197 amino acids

Function

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Similarity

Belongs to the cingulin family.

Mass

136.248 kDa

Sequence

MAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGIAGQPFVVLNSGEKGGDSFGVQIKGANDQEASGALGSDFELPENPYSQVKGFPAPSQSSTSDEEPGAYWNGKLLRSQSQASLAGPGPMDPSNRSTSMLELAPKVASPGSTIDTAPLSSVDSLINKFDSQLGGQSRGRTGRRTRMLPPEQRKRSKSLDSRLPRDTLEERERQSTNHWTPSTKYDNHVGSSKQPSQSQSPSPPSGFSRSRQTQDWVLQSFEEPRGRAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMISSGSTKAVAGQGELTRKVEELQRKLDEEVKRRQKLEPSRVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEGLRHGLEAQVMELQNKLKQVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLQTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEAAVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKHLLDRTVDRLNKELEKIGEDSKQALQQLQAQLDDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLEAELDEEKNTVELLTDRVNRGRDQVDQLRTELLQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQRELEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKHEGLSSDEEFDSVYDPSSIASLLTESNLQTSSC

Protein

Cingulin: CGN

Gene

Cgn

Protein

Cingulin

Organism

Mus musculus

Length

1191 amino acids

Function

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Similarity

Belongs to the cingulin family.

Mass

136.447 kDa

Sequence

MADPRGPVDHGVQIRFITEPEGATEMGTLRRSGRRPARDARASTYGVAVRVQGIAGQPFVVLNSGEKGTDSFGVQIKGGNNRGSPGALSSDSELPENPYSQVKGRPATSRSSTSDEEPKDHLNGKLIRSQSQASLTGLAFMSPSNRSTSLLELAPKPTSSINTIDTAPLSSVDSLINKFDSQKGGQVRGRTGRRTRTLPHEQRKRSQSLDSRLPRDTREEREHQSANHWTRGTKYDNHVDSSKNPSQKQSPFSSFSRSRQTQDWVLQSFEETRDPAMVQFKSTPDLLRDQRETAPPGSADHVKATIYGILREGSSESEASVRRKVSLVLEQMQPLGMVSPASTKALAGQAELTRKMEELQKKLDEEVKKRQKLEPSRVGLERQLEEKAEECHRLQELLERRKGEVQQSSKELQNMKLLLGQEEGLRHGLEAQVKELQLKLKHSQSPDSGKESLLKDLLDTRELLEELLEGKQRVEEQLRLRERELTALKGALKEEVASHDQEVEHVRLQYQRDTEQLRRSMQDATQDHAALEAERQKMSSLVRELQRELEETSEETGHWQSMFQKNKEELRATKQELLQLRMEKEEMEEELGEKMEVLQRDLEQARASTRDTHQVEELKKELRRTQGELKELQAEQQNQEVTGRHRNQVLEKQLAALREEADRGRELEQQNLQLQKTLQQLRQDCEEASKAKVASETEAMMLGQRRATVETTLRETQEENDEFRRRILGLEQQLKEARGLAEGGEAVEARLRDKVHRLEVEKQQLEEALNAAQEEEGNLAAAKRALEVRLDEAQRGLARLGQEQQALNRALEEEGKQREALRRSKAELEEQKRLLNRTVDRLNKELEQIGDDSKLALQQLQAQMEDYKEKARKEVADAQRQAKDWASEAEKNSGGLSRLQDELQRLRQALQTSQAERDTARLDKELLAQRLQGLEQEAENKKRFQDDKARQLKSLEEKVSRLEAELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERRVKELSIQIDDERQHVNDQKDQLTLRVKALKRQVDEAEEEIERLDSLRKKAQRELEEQHEVNEQLQARIKSLEKDAWRKASRSAAESALKQEGLSSDEEFDNVYDPSSIASLLTESNLQTSSC

Protein

Cingulin: Cgn

Gene

CGN

Protein

Cingulin

Organism

Canis lupus familiaris

Length

1190 amino acids

Function

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Similarity

Belongs to the cingulin family.

Mass

135.53 kDa

Sequence

MAEPRGPVDHGVQIRFITEPVGNAEMDTLRRGGRRPAKDARANTYGVAVRVQGIAGQPFVVLNSGEQGSDSFGVQIKGTNNRGPPGALSSDSELPESTYSHAKEFPARSQGSMSDEELGAHWNGRLLRSQSQASLKGPAPVSPSTRSTSLLQLAPEVASPGSTIDTAPLSSVDSLINKFDSRQGGQARGRTGRRMRTLPPEQRKRSQSLDNRLPRDTLDEREHQFPTHWTPSTKRDSHMGNSKQSSQNQGPLGGFSCSRQTQDWVLQSFEEPRGRAWDPGMLQFKSTPDLLRDQQETAPPGSVDHVKATIYSILREGSSETETSVRRKVNLVLEQMQPLVMTSGSAKGLTGQSELSQKVEELQQKLDEEVKKRPKLESSRLGLERQLQEKAEECSQLQELLERRKGEAQQSTKELQNMKLLVDQSERVRCGLEAQVKELQDKLKQAQEPEPAKEALMKDLLEARELLEEVLEGKQRMEEHLRLRERELTALKGALKEEVASRDQEVEHVRQQCQRDAEQLRRSIQDATQDHAALEVERQKMSTLVRELQKELEETSEETGHWQSMFQKNKDELRATKQELLQLRMEKEEIEEELGEKIEVLQRELGQARAGAADTRQMEELKKELCQTQKELKELKEEQQNQEVAGRHRERELEKQLKVEADRGQGLEQQNLQLQKTLQQLRQDCEEASKAQVAAEAEVAVLGQRRAAVEVTLRETQEENDEFRRRILGLEQQLKEARGLAEGGEVAEARLRDKVQRLEAEKQRLEEALNAAQEEEGSLAAAKRALEARLEEAQRGLARLGQEQLALNRALEEEGKQREALRRSKAELEEQKRLLDKTVCQLNKELEQIGNDSKQALQQLQAQLEDYKEKARREVADAQRQAKEWATEAEKNSGGLSRLQDETQRLRQALQASQADRDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLEAELDEERSTVELLTERVTRGRDQVDQLRSELMQERSARQDLECDKISLERQNKDLKSRLASSEGFQKPSASLSQLESQNQELQERLQAEEREKTVLQSTNRKLERRVKELSIQIDDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQRELEEQHEVNEQLQARIKTLEKDSWRKASRSAAESAQREGLSSDEEFDSVYDPSSIASLLTESNLQTSSC

Protein

Cingulin: CGN

Gene

cgn

Protein

Cingulin

Organism

Danio rerio

Length

1161 amino acids

Function

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Note=Localizes to the apical junction complex composed of tight and adherens junctions.

Similarity

Belongs to the cingulin family.

Mass

130.821 kDa

Sequence

MSSLSADRKPPLDYGVQIRFIKDLDDAGGGFPDKSRLANGVGGVSNGTSSPSKYGVAVRVQGISGQPYVVLQDGEKGDSYGVQLKTQPQIQSAPPVVSQTSPYNTLLLGQREGARTPQGSYNPTDQPSSPDEDFGSPLRRPPGDGQAGTQGEAEPRTTERFTPSALAPKLDKKDNDAFNEAGLRKVKQNGIGSSLNGTGLNGSFPPPSSAQDEDQAPAIDTKSLAPINKLISRFGGGGGGSGDILNSEAQTRPRLDNRVRSQSADALNKPSEEASSTSPTINPYAPNTSATVPKLNSTKPSSTGSLGRDATSVAKVAAIPNFKPLAFNQSPKLFAPKEAPPAVPKKPVTPDLIKSQTTSIENGNGEDDQTKQAIYNILKEGSIEKEEAIKRKASLIHERFCGVKAPQISVTDSNMKTELEQAFGRNTQLQQQLDKSRRELQENQDQMVELRMDREGAESRLRQQEDQLAQLQEELRRTLENSPQSDSMQLDLLTVQAELSESQLLRQKLEDTLRQRERELTALKGALKDEVASHDKEMEALREQFSQDMDALRHSMETVSQSQLEIEEERQKVNASILAMEEELEGYKEQSEQWKKQFSSANQELLKAQQGKRELEEKLLAVVKQTDETDSNSVMKELQQCRDSLKKAQSELEKQKAETLKKQEELKSATRASEKRETELKAEIDRLINQLKKEKEELSKAIEKTQQPLVSDQTKDPESNLELQEANARLRERIARMTRLHSSVPDSSSSDALEEENRSLKTQLEESRRAASRLGVEKEELNRRLEEREREREALRRGKSDLEEQKRLLDRSLDKINKEMESMMGDSRQSVQVLQSQLEEFRDRSRRELQDAQRLSKDRLVELQRAQALLKTTQEEVSRVKKELLSCTEERDSTQLDKELLSSRLKNMETELQTDRSSQTDRSREIRLLEDKVKTLEIELDEEKSGAELLNERITRCREQVDQLRSELMQERSARHDLEMDKSALERQIKELKSRIADMGTQSRPSAGVTMLENKVQELEDRLRSEEREKNTIQAAQRRLDRKLKDVTATLDQERNQHAEQRDQLSLRVKALKRQLDESEGEVERLEGVRRKVLRELEEQRELQAALQAKVNAMDNELRKIQQSRRSTLGSTLSSDEEDNYSDTKSITSILTDSPLQTTSC

Protein

Cingulin: cgn

Gene

CGN

Protein

Cingulin

Organism

Sorex araneus

Length

1153 amino acids

Function

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Similarity

Belongs to the cingulin family.

Mass

130.489 kDa

Sequence

MAEPRGPVDHGVQIRFITEPAGDAQMRTGRRPAKDARANTYGVAVRVQGIAGQPFVVLNSGEKGSESFGVQIKGAHRQGPPGAPHSDLELPAEHSRPLAQENAGTWQGSVSDEELGDPWRGRLLRSQSQASLLGPAPLGPGHRSTSLLELGPPGLGAGSAIDTAPLSSVDTLIHKFDRHQGGQARGRTGRRMRALPAEQRKRSQSLDSRHLRDPPEDRRSPIPWAPPSRPGSAGSSKQPAPKPIPTSSYSRARQTQDWVLQNFEEPRTRAQDPAVLQFKSTPDLLRDQQEAAPPGSVEHVKAALYGILREGSSESDASVRRKVSLVLEQMQPLVMTTGSAKVLAGQGELAQKVEELQRKLDEEVKKRQVLEPSRLELEQQLEEKAEECLRLQELLERQKGETRQSGTELQNLRLLLDQAGRVRSELETQVMELQDQLKQGPVPAKEGLMKDLLETRELLEEVLEGKQRVEEQLRQRERELTALKGALKEEVASRDQEVEHVRQQCQRDTEQLRKSIQDASQDQAALEAERQKMSALVRGLQRELEETSEETGHWQTMFQKNKEELRAAKQELLQLRMEKDEMEEELGEKMEALQRELGQARAGAGGSRQVEELRKLQGEAERVRELEQQNLQLQKKTQQLSQDCAEATKARGARMAAEAEAALLVQRRTAVETTLQETQGENDEFRRRILGLEQQLKETRGLAEGGEAAEARLRDKLQRLEVEKQRLEEALSEAQAEEGSLAAAKRALEARLEEAQRGLSRMGQEQQALSRALEEEGKQREALRRGKAELEEQKRLLDRTVERLNKELEQIGEDSKQALHQLQSQLEDYKEKSRREVADAQRQAKEWASEAEKSSGGLSRLQDETQRLRQTLQASQADLDTARLDKELLAQRLQGLEQEAEKKRRSQDDRTRQVKSLEEKVSRLEMELDEERNTVELLTDRINRSRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKGRLASLEGFQKPSASLSQLESQNRELQERLQAEDREKTVLQSTNRKLERRVKELSIQIDDERQHVNDQKDQLSLKVKALKRQVDEAEEEIERLDGLRKKAQRELEEQHEANEQLQARIRALEKDSWRKAARSAAESSLQQEGLSSDEEFDGVYNPNSIASLLTESGLQTSSC

Protein

Cingulin: CGN