Protein
U6 snRNA phosphodiesterase
Organism
Drosophila melanogaster
Function
Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.
Similarity
Belongs to the 2H phosphoesterase superfamily. USB1 family.
Sequence
MALVDYGGSSSSASEDEDCTENIQTPALITLKRPALPKAATLLGPKKPKPEEFVEDVVDDPAEHGGRMRSFKHERGNWATYVYVPATACVDQLEEFQTEAIARLEPHLELQPNESLHLSLSRTVVLQYHQIDEFSRSLQSALNSSAGFAATLQGLRIYTNEERTRTFIAAPLDAAFVEKMTAILQPIDQVMLDYRLQQFYDPASFHVSLLWCVGDQETLLNEKLTELKELLDDQDKLCLAVNEVHLKCGNKDFTYSLK