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CEP295

Gene
CEP295
Protein
Centrosomal protein of 295 kDa
Organism
Homo sapiens
Length
2601 amino acids
Function
Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865). Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865).
Mass
295.176 kDa
Sequence
MKRKVVNTHKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQEKLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKVKGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEICSSETDVPLVMKTQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKERTLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQEAAARIRMSARQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKKTQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNRLHRQSVETARKQLLEYQTMLKGRCPSVSAPSLITDSVISVPSWKSERPTAISEHWDQGQRLKLSPNKYQPIQPIQTSKLEQDHFQVARQNHFPQRQVETTETLRASDILTNQALESQEHLRQFSQTETQQRDYKLVPKDSETLSRALSHDRQLISQDARKISETFGATTFQSLESQQLFSENSENISYHLTEPSSFVPLVPQHSFSSLPVKVESGKIQEPFSAMSKSTVSTSHSIISQMHDRPLLPSENITAQQGNMKALQEQLDLQKKVLQATQEAQEQLLLCKQKEVEQQTGLSVFLPLVTPDSSALLPSAKADLGRIQESSPTKNNIAVSSDHHVISQLQDKRLSLSQPILSQQNNFKFLQEQLNIQKDSLQARREAQEVLYVHKQSELDRRVCSEQAEPSFPFQVAQHTFTSLPSADTKSGKIQEQHSSKSEKGLVSCQSDIPISQDGSLSFLQQFLPLHDSLKLLQEQLTKQRDTLQARHEAQVELLLHRQRDLGDSKSGLVSSSSSPVVVQHSVASQASAKAEPRRIQELYLSEKENVGPSCHLIIPTFQDKSLSFPQHSLAQQENLTILQEQSQIQRVILGAKEGTQEFVHTESELEKRISSEQTGTSSSLSQVDESERFQECISIKSDSTIPLSHPKIPRCQERLLRVSQHMLPLQDNLEEHQAWLDTEKEAFHFSQKTQENTSSEQTGSSSFIPQLVQLSFTSLASAESGTILEPLFTESESKIFSSHLQIPQLQDRLLRISQLIQPQQDNLKALQEQLATQREAIILARQEAREELLLHQSEWEGRISPEQVDTSSLPLVPQHSFASLPLNESERNQEPCSINSDNIVSSGHSEIPTLPDGLLGLSHLVLPQQDNLIALEEHLHAQTDFLPSIEKTQKELVLSKPCKFEEKVSSEHFIQSHHGDLQALQQQLDTQKKAIRSIQEVQEELLLQRLSELEKRVSSEQVCSSSFVSQVPVADSERTQKSFPTKSNDTLPSSHREIPRLQDRLLSLSKPILPQQDNMTAQLDAQREVMYSYEKPQEELSLNKQRKLNKSESAEHTIPSLFLPKETEHSFIPLPFAEAKPKSTCELYSSQNEHAAPPSNPVIPGFQDRLLSFSQSVLTQQDNLGLQKQLDLQREVLHYSQKAQEKLLVQRQTALQQQIQKHEETLKDFFKDSQISKPTVENDLKTQKMGQLRDWFPNTQDLAGNDQENIRHADRNNSDDNHLASEDTSAKQSGEHLEKDLGRRSSKPPVAKVKCGLDLNQHELSAIQEVESPAIGRTSILGKPGIYEDRDPLRVSISREQSFFGSPLAHDPFSCLQLVGQENVCGDDYDEAVKLKESVVENHAVLSYAVEEEHAYLGPTVKPDDKAKTLSYEPLSSATVSTGSLLSYENTDLSLTDPESFSEHMDDSKQESTTSKEEETNIISSIVPSTQDIYQRQNSSDVHKSLLPAVDETTCGHTHFQQMIDKYINEANLIPEKTDLQELEHIFPNLHHQLFKPLEPHPDFDLSSSSSGISPDNRDFYQRSDSSSESHCATGLSKSTVYFTALRRTSMHSSLNTSPNQQPDTNLAHVGAHSFATENIIGGSEQCFEQLQPEYSSQEESQHADLPSIFSIEARDSSQGMKNQNYPSEEHTEILQNKKKIVHFQLSIGNLSSVYSSSDEANVFDQLNVQHSTPCGSNSSECSTKHQLESRKESMGFEELSKRGVVTMLQSQGLIEDNKNETCRVLDINPQVEETDSRLCVRTVEMGTSIQAPYSLTTQNEKYFENSAETDIPKITKKLSQLGESELFASSGSFSLQSSIPVWETETGHGIMEEPELTLISTTDTSIAEMDFANLTLEEKSENEAKCFFQVSEFLPLVSATEASDYPAVSELSIEKPRTASTETPRRLTPVPGSLQEAFIKRKKSFMERSHQRQKEIRNKIHVSENSQIKTVKEKPSISSSVSRLKGVNKVRASFPEDRKTTQALRHQRGLRLYNQLAEVKQQKEEKTKQEAYAQNRARAKEFHKKTLEKLRAKNTC

Gene
Cep295
Protein
Centrosomal protein of 295 kDa
Organism
Mus musculus
Length
2412 amino acids
Function
Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement. Binds to and stabilizes centriolar microtubule.
Mass
272.779 kDa
Sequence
MKRKGMNTKLRLSPSEEAFILKEDYERRRKLRLLQVREQERGIAFQIREGIKQRRSQQVSHLAEELRAKWEEAQSQKIQNLEKLYLASLRHMGDGHRQAKENEPDLDALSRRAAERKRKAEVRHKEALKVQKNQKEMLMKQKTRHIKARKEAVLVEKQRSAKMARLPPPVPSPFENIDVNRIPSLKTNSSTYHHISTFVSRQMGTKQPDAHLAAEEEARRVERLRKQAAQERVKQFERAHVRGSQAMKKIHLAQNQERLMEELKQLQKEDLARRRQTVAQMPPQMLELPYRRSEMKEDRQRELEFAFEDMYNADRKVKGNLILHLKPEPLPTISDQLQDEELDLSMEQENQVPLAAKIQQIPSRILFKRLLNKIRSQKSLWTIKSVSEDEGEVTSSIIEIESKVPSVDSGAIITEERTAASFEQEQVTDSDRLTIESGPLSSEDKPLYYKAGTGREQAMAVSPPATAVAQSSVLLHPQEEAVRIRMSLRRKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEQRKQADQPEVCCAPMSHAMISDEDSHRQMIRNYQHQLLQQNRLHKETVETARKRLLEYQTVLKERSPSLSASALVPDSVVSGPPQQSYKPAAASDSWDPSQRLKLSPSKYQPVQPSQIPALEQSHIQVPRHGHITQRQGKMAVSEMLGKQPVESQERQWQFSQVETHQGDYEFVLKDSHSLSRTLSYVRPQTLQDAREVSKPPRVIICQSLDSQQISSEDSENISSKPSEPSPFLPLVPERPFTSLPVKFHSGTIHKPFTTINQSVISQMHDQPLSSSETITAQQGDLRFLQEQLELQKKVLQARQEAREKLLLCTQKELGQQTGLPVFLPSPAGNIFSSLPSASAESGNFQTSSTKSDATVSSDNMDRLWDSSQPISSQQTHLEFLQEQSSVETDNLQARREAQEVLFAHTQNTLEKIVRSEQAGSSLPHQVAQQSFSSLTLADTQSKKIQKQPLPANKKGLLPSQSEVSKAQDGSSGFLQQTLPLQNTLKLLQEQLTRQRSMIPPRRDGQETLLLYKESCSEDSEAGPVESLSSVVVQHADASRAVSEVPKRLQDVYSSEEENRVLSSHLITHGFPQHSLQRQEHFTPLQEETHIQRLILGARKNNEEFAPKQNELEKGLCSQQTDALSSPSQVTDWGTSRGSVSVRSDRTDPLRHFKIPAFRERLVRVSQHTFPLQDNLQEHQEWVDTEKESFQSSPLTPENPSSQQTGFSSFKASLRLPSCVSLPSADSGITQHPLSTESDSKVKSSHLQIPELQHRLSKISQLIPPQQDSLKALQEQLATQREAIIHSRQEAHEETLREWKEKIFPEQVGPFSPLIPQHSLASFPVSDTERAQELCSTNSDTISSGYPEMLELPDRTLGLSHTALPQQNNLTAHPEHLHAQTNFFHSTEKAQEGLVFPRPCQFEEMSAEHFIQPQHDDLKALQQQLDMQREAIRSGQEMQEKMLLQRLNKLEQRISSKQISSSLFSSQVALPIANSDGTLQSFPTKSNETELLGSQDEYLSFSQPRLPLQNNMTEQLDLEKVFHKELLLHKQKSQNKSESSEHSLPPLFLSKEIEHPFISLPFAESKSKSICELYLSDKKHAAPNDAVIPRLQDRLLSCSQPVLTQQDNMSLQKQLNLQRETLHSRQKAQEELLVQRQTSLQQQIQRHRETLKNFFNVSQARNPTDENDLEMQKREQLGGWFPHTQGLTWGDAGQGSANGEQPRADVHAEHNGESLAKELSGRASKPPVSKVKCVLDLNQHELSTIQEVESPASGRISMPGKAEFYQDRDPLRVSVSREQSFLESPLAHDPFGCHQPPAQENSKSHDDNAEAVKVKKSDVEDHAVLSHAVSKEEACTNLGPLGKPDDEAETQEISQEPLSSVTVSTGSFLSYEITDLSLTDPESFSEQTEHLEQESTNKQEETDPLSIAVPSVIYQQQHSLGAHNSLLPMEEESTSDHTHVQQIMDNDVNEANLIPDKRDFQVPAVDLDFRELEHIFPHLHRQLFKPLEPHLDFDLSSPGTSQEDSDFYQSSESSSEKHVKALSTGTICFPALTAKSHSPNPRLNQLDINLAHATTEGSEQSFQQLRPEFSSQESQHADLPSIYSIEARGPSQRMENQNYSEMLQNKKKSLSLQPSTEDLTPACSSSDTALFDQLHLQHSTPCASVSSECSVKLLESREEVLGFEELSRRAVTMSQRLTEDENVVLPINPHVGRVEKEASVQGSNPLSIQNEKPIQNFIETDTTEAVGNVCQLAQAEHILKSCPFRSPIPIWETDTGYGIMEEPDLTLVSNSDISITETDLANLTLEDREDNEAQFFQAGVVLPTSSMETSVCGAVSEPYVDQPTVAPSATSGSLQEAFMTRQTLTERSYQRQREIWNKTRLPQTKVSKEKLPTGCTGS

Gene
Cep295
Protein
Centrosomal protein of 295 kDa
Organism
Rattus norvegicus
Length
2395 amino acids
Function
Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement. Binds to and stabilizes centriolar microtubule.
Mass
269.982 kDa
Sequence
MKRKVMNGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERGIAFQIREDIKQRRNQQVSHLAEELRAEWEEAQSQKIQNLEKLYLASLRHMGDGHQQAKENEPDLDALSRRAAERKTKAEARHKEALKAQKKQKEMLMKQKTRHIKARKEAVLVEKERSAKMARLPPPVPSPFENIDINRIPSLKTNRSTYHHISAFVSRQMGTKQPDAHLAAEEEARRVERLRKQAAQERMEQSERAHARGSQAMKKIHLAQNQERLMEELKQLQREDLACKRQTAAQMPSQLLELPYRRSEMKEDWQRELEFAFEDVYSADRKVKGNLILHLKPEPLPTMSDQLQDEELDLSMEQENEVPLATKTQQIPSRILLKRLLNKIRNQKSLWTIKSFSEDDNQVTASIISEIERKVPSTDSGTITTGETAVSFEQEQVMGSDRLMIESGPPSSEDKPLCYKSVTGKEQAMGVSPPATTVAQSSVLLHPQEEAARLRMSARHKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFQAQLEETRKQADHLEVRPAPVSHAMISDEERHRQMIRNYQYQLLQQNRLHKQTVETARKRLLEYQTVLKERCPSMSARSLIPDSVVSEPPQQAQKPAVASDYWDPSQRPKLSPSKYQPVQPSQIPALDQNHIQVPRQGHIPQRQGETARAKQSVESQERQWQFSQVETQQRDYEFIFKDSHSLSRTSSYVRPQTLQAAGEVSKPLRAIICQTSDSQQISSEDSENISSKPTEPSSSLPLMPECSSSSLSVKLESETIQKAFTTVNRSVISQMHGQPLSSSETGTTQQGDIRFLQGQLELQKKVLQERQEAQEKLLSCTQKELEEQTGIPVFFPSPVGNMFSSLPSASAESGNIQTSSTKSDATVSSDSMDNPYSQPISLRQTNLEFLQEQFSVEKDNLQARREAQEVSFTHTQSKLDKIVRSEQTGSSWPQLVALESFSSLTSADTQSRKIQKPPLPTNKKGLLPSQSEILSSQDGSSGFLQQTLPLQNTLKLLQEQLTIQRGMIQPRLNAQETLLLHKERCSVDSKAGPVNSLSSAVAQHSEAGPQSLQELYSSKKENTVLSSHLITPEVQEESHGSPQHSLPRQEHFASLQEQAHIQRVILGARKQIQEFAHKQNEFKKGLYSQQTGALSSPSQGTGWEISQESLSVRSDSTDPLSHFKIPGFQERLVRALQPTFPLRDNLQEHQEWVDPEKESFQFSPQTQENRSSQQTGFSSFTPSLRQPSCVSLPSVDSGITQHPLSTERDSKVTSSHLQIPELQHRLLKISQLIQPQQDSLKALQEQLATSRTIIHSRQEALEETLREWKEKIFPEQVGPFSPLMTQHSFASFPVSDIERAQELCSTNSEGAISSGYSEMLELPDRALGLSCTALPQQGNLTVHPGHLHAQTNSFHSTEKAQEKLVFPRPCKLEEISAEHSIQPPHDDLQALQQQLDVHREAIRSCQDIQEELLLQRLNKLEQRVSSKQISSSPLLSQVALPIANSEGTLQSSPAKNDDTEMLRSHSEYLNFSQPLQDNVTEQLDLEVVFHKELLLHKQKSQTKSESPEHAAPFNDAVIPRLQDRLLSYFQPALTQQDSMSPQKQLNLQREALYSRQKAQEELLVQRQTALQQQVQKHRETLKGFSNVSQTRAASGENDLEMQKTEQLTGWFPHIQGWPWGDSSQGSSSGDQPGAAAVHAEHSGESLGKELSGRASKPPVSKVKCVFDLNQHELSTIQEVESPTSGRTSMPGKAEFYRDRDPLRVSVSREQSYLGSPVAHDPFGCHQPSVQENSKSHDTAKAVKVKKSDIEDHALLSHAISEEEEEEEACTNLSPLMKPDDEVETQEISQELLSSMTVSTGSFLSYEITDLSLTDPESFSEQTEHQEQESSSKEEETGSLSCAVPSTQVTYQQQHSLGAHNSLLPTEEENASDQTHVHQIIDKDINEANLIPDKRDFQVPAVDLDFPELEHLFPHLHRQLFKPLEPHLDLDLSSPGTSQEDRDFYQQNSESSSEKHVKALSTSTLCFTALTAGSHSPNSRLNQQLDVNLAHATTEGSEQSFQQLLPEFSSQESQHTDLPSIYSIEARGTSQSMENQNYSEILQNKKKSIYFQPSTENLSPACSSSDTTLFDQLHPQHSTPCGSVSSEGSVKQLEGREEMLGFEELSRRAVPMSQRLTEDENVVLPINPYVGTVEMETSIQGSNSLSIQNEKPIQNVIKTETTKAVRNVCQLAQEEHMLKSESCPFRRPIPVWETETGYGIMEEPDLTLLSTSDISITDTDLANLTIEDNEAQCSQAGAVQPSSSVETTFCGAASEPWADQPTVASSAIPGSLGEAFMKRKKTFMERSYQRQREIWNKTPLPQAKVSKEKLSTSSSLSHLKEAVSGDETAKRNRSQCI