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CEP19

Gene
CEP19
Protein
Centrosomal protein of 19 kDa
Organism
Bos taurus
Length
163 amino acids
Function
Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes.
Similarity
Belongs to the CEP19 family.
Mass
19.189 kDa
Sequence
MMCTAKKCGIRFQPPAIILIYENEIKGKSRQRIMPVRNFSKYSDCSRAAEQLKNNPRHKGYLEQVSLKQLEKLFSFLRGNLWGQSLAETMEQIQRETTIDPEEDLNKLDDKELAKRKSIMDELFEKNQKKKDDPNFVYDIEVEFPQDEQLQSCGWDTESAEEF

Gene
CEP19
Protein
Centrosomal protein of 19 kDa
Organism
Homo sapiens
Length
163 amino acids
Function
Required for ciliation (PubMed:28625565, PubMed:28428259, PubMed:28659385). Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28625565, PubMed:28428259). Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes (PubMed:28659385).
Similarity
Belongs to the CEP19 family.
Mass
19.166 kDa
Sequence
MMCTAKKCGIRFQPPAIILIYESEIKGKIRQRIMPVRNFSKFSDCTRAAEQLKNNPRHKSYLEQVSLRQLEKLFSFLRGYLSGQSLAETMEQIQRETTIDPEEDLNKLDDKELAKRKSIMDELFEKNQKKKDDPNFVYDIEVEFPQDDQLQSCGWDTESADEF

Gene
Cep19
Protein
Centrosomal protein of 19 kDa
Organism
Mus musculus
Length
163 amino acids
Function
Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes.
Similarity
Belongs to the CEP19 family.
Mass
19.17 kDa
Sequence
MKYIAKKCGVRFQPPAVILIYENETEGKSRQRIMPVRNFSKFSDCTRAAEQLKNNPRHKSYLEQVPLKQLEKLFVFLRGSLQGQSLAETMEQIRRETTIDPEEDLNKLDDKELAKRKSIMDELFEKNQKRKDDPTFVYDVEVEFPQDEQLLSCSWDTASVDDF

Gene
Cep19
Protein
Centrosomal protein of 19 kDa
Organism
Rattus norvegicus
Length
163 amino acids
Function
Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes.
Similarity
Belongs to the CEP19 family.
Mass
19.149 kDa
Sequence
MKYIAKKCGVRFQPPAMILIYENEAEGKSRQRIMPVRNFSKFSDCTRAAEQLKNNPRHKSYLEQVSLKQLEKLFVFLRGSLQGQSLAETMEQIQRETTIDPEEDLNKLDDKELAKRKSIMDELFEKNQKRKDDPSFVYDVEVEFPQDEQLQSCSWDTASVDEF

Gene
cep19
Protein
Centrosomal protein of 19 kDa
Organism
Xenopus tropicalis
Length
163 amino acids
Function
Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation.
Similarity
Belongs to the CEP19 family.
Mass
19.194 kDa
Sequence
MSYMAKKCGVRFQPPAIILVYEDKEAGKSRQRIMPIRNFSKYSDCSRAAEQLKNNPRHKDYLDLVSLRQLEKLYKLLKGHLKGESLKVTLEEIKKEETIDPEEDLNKLDDKELAKRKHVMDELFEKNRKKKDDPDFEYEIEVDFTKDEQAESCGWDDASDEGF

Gene
cep19
Protein
Centrosomal protein of 19 kDa
Organism
Danio rerio
Length
161 amino acids
Function
Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation.
Similarity
Belongs to the CEP19 family.
Mass
18.905 kDa
Sequence
MSIVAKRCGVKFTPPSIIIIYENKTSGKMRKRVIPVRNFSQYSDCSRAAERLKHHVRHSVYLECVSLAQLERLHLLLRDHLQGASLEESLAAHRHQEEEEDLNKLSDEELSRRKAQMDDLFQRNRRRRGDPDFVYDLEVEFGEGSVKETCSWDEEQSDQEF