CDCA2

Cell division cycle-associated protein 2

1023 amino acids

Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.

112.676 kDa

MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTVTVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ

CDCA2

Cell division cycle-associated protein 2

1011 amino acids

Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity).

110.998 kDa

MDTCSQESEPLQTKESPINNAGKTPLVLGNGKLVTPHKQAAEMTPNCYTSETFKSPLNFSTVTVEQLGISPESFVNNSSGKSSPYLKKSRRRSTVGLRGLPETNHLIRFVAEQRSLKNASLTQTSPFQGSPALYRNVYSLREQMSAFHLAFNSIKENEKMTDCPEFSEAEGVFKTRGSTKKESLGECQLSEFSAQSSSKRRRLSSPSSSDVNLTDAVDLQACGVNMAACPSTDMKCAVETCAGLSQKSSASGLNLQCGCLMNESPLLSELTEASSGIQDAASVEERGSNDAVSVDKCTEVSTDTAPEVRSLVTPLCQKDLPSSKTFVLRSVLKKPAVKLCVESLQEHLDNLYNDETCPSLTSSLANSCKEQTAALPNTKKRKRVTFGEDLSPEVLDESLPANTPLRKGQTPVRKKDLSSLSPPLLEQSPVPEWLPQPNFDDKEENLENIEPLQVSFAVLSSLNMSSIAETLSGTDTSASSSNHENIAPFRVGRATRTSDRRSKLISFSQESVCNLLNAEAQPCKEKKTNRRKSQESKHADKVLPRKNRVLKGCKKKKGKGKRKGVQKSLYGERDLASKKPLLSPIPELPEVSETPLVGSLVRRTYPDDFNSNGKFEEMMLPKRENLLSQDPEDWQVIQGFNKDNASESCSSDMKSSSSFSNATFEQDANINSIEMDENENIPKAITLESENERKTGTECENSHISCTLVTVTPVVSDNPKPDFPLQSQELSAAGQNVENLFQIVKISEDMNIKCEKQSGFSVIPEDKLQTEHLIPDSQKECDCSEDVLTDQRKVSKSQGEDLGRNSAASCSGVSDRERKYRGHSVGGSDGPGLHLERTNNLQTSYSMSSLVEISLENSELCKDLSDSIEQSLQRTKSETKVRRSLRLQKSLEREGGLVWVSPPPPPASCTSQRTKRRTVGTLDSRGFEPVSSRQDPCTLPSTSSEENGEGFTAAPDASLPGKRRRRSFCTSTLANPKSTTQSRGCKRRSFLGQKRENTLQETSRESDLSEN

Cdca2

Cell division cycle-associated protein 2

982 amino acids

Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity).

106.366 kDa

MDASSHDKPLSESKECVLNNSENDVFRLGTEPFVTPQKHVADATPNLCTPDTFKSPLDFTTVTVEQLGITPESFVKTSSGKSTSSLQKARRRSTVGVRGSPETNCLIRFIAQQRNLKKAVLSPLAREPHFEGSPRLYRNASVLRERMSAFRSAFHSIQETKMASSPSAAEADGESRISDLTRKEDLLEYQQSGFPVNSSSKRRRISSQDSPDNYLSGTKALADEACAGGASTDLAEKSPDIGSAQPGCMAAPLPELRETSQGLAVTDCVEGPVTPLSSGTATATRSPETPMCGSSSPSAKTTATRSPATPVCGSSTPSAKTFVLRSVLKKPGKLFSENGKESNLCDDGAHLISYPSNSCKEGRAGRENCKTPGCLNPRKRKRVTFGEDLSPEVFDESLPANTPLCKGGTPVRPRTVKTTSPLQSPVHEQFLQPNFDDKEENLENIEPPQGSFANLSLSKSSLSETPPGTNTCSSLNKDEEIICSIVRPTRTSQRRKQTLSSTGVCSSYTTQAEPRKEKMSRRKSREKKHTSAALPKKKQVLKSYRKKKKGKKDVEKCFYGPRDIASKKPLLSPIPELPEVSEATPLADCTQGTSSDDFNKCGQLEEVNSFEIPTQRKRRLPQKADSPELDPAHHQSQVSDKCCYLLPLTTASERGPNASTRDTGSEGNTRAESKCQSAKEPKPGTKMESGLVPRASVTQDHIVSKNPKPLGSPQSQDLFKAGQNLENPCEILIVSESMNLKCEKESECLAPQGSLQGSPVSTDSKRDLNCSEDVLIQNIKEPASHSENVGRKCAGNGSPGSGRERKWRRRTVCCGGQSSYLEQNGNPASSCSGENFVEISLESVQLIEELSNTIEQSFQRTSSKTKVRRSTRLQRDLENTGLVWLSPSPSTLQKPRRRMTICTLDSRGFECPSSKEETISSGQNPGPLPAVSGSESQGVGSSALPRKRRSLCGSTLTDANSATQPPDCKRKPSLKGESAQLP