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CDC2

Gene
CDC2
Protein
Cyclin-dependent kinase 1
Organism
Ajellomyces capsulatus
Length
324 amino acids
Function
Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis (By similarity).
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Mass
36.824 kDa
Sequence
MENYQKIEKIGEGTYGVVYKARDLTHPNRIVALKKIRLEAEDEGVPSTAIREISLLKEMHDPNIVRLLNIVHADGHKLYLVFEFLDLDLKKYMEALPVSEGGRGKALPDGSTLDMNRLGLGEAMVKKFMAQLVEGIRYCHSHRVLHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGGRQYSTGVDMWSVGAIFAEMCTRKPLFPGDSEIDEIFKIFKLLGTPDENTWPGVTSFPDFKASFPKWKREDTRKLVPGLERNGLDLLDAMLEYDPARRISAKQACMHPYFQAGSSAYSGRERLQPYP

Gene
cdc2
Protein
Cyclin-dependent kinase 1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
297 amino acids
Function
Plays a key role in the control of the eukaryotic cell cycle. It is required for entry into S-phase and mitosis. When complexed with cig2, plays a role in G1-S phase transition. When activated and complexed with the cyclin cdc13, it leads to the onset of mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Involved in cell cycle arrest induced by defective RNA splicing. Required for phosphorylation of dis1 to ensure accurate chromosome segregation and for the DNA damage checkpoint.
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Mass
34.359 kDa
Sequence
MENYQKVEKIGEGTYGVVYKARHKLSGRIVAMKKIRLEDESEGVPSTAIREISLLKEVNDENNRSNCVRLLDILHAESKLYLVFEFLDMDLKKYMDRISETGATSLDPRLVQKFTYQLVNGVNFCHSRRIIHRDLKPQNLLIDKEGNLKLADFGLARSFGVPLRNYTHEIVTLWYRAPEVLLGSRHYSTGVDIWSVGCIFAEMIRRSPLFPGDSEIDEIFKIFQVLGTPNEEVWPGVTLLQDYKSTFPRWKRMDLHKVVPNGEEDAIELLSAMLVYDPAHRISAKRALQQNYLRDFH

Gene
CDC2
Protein
Cell division protein kinase 2 homolog
Organism
Entamoeba histolytica
Length
291 amino acids
Function
Probably involved in the control of the cell cycle.
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Mass
33.845 kDa
Sequence
MTRYEKKQQLGEGTYGVVCKAWDTVCNRYVALKKIKQEREDDGIPVTSVREIAVLLELKHPNVVDLYDIYLEDKFLYLVFEFCDEDLYQFMSRSSKIPINETRSIVYQILQGLAFCHYHQILHRDMKPQNILINKNGTIKLGEFGLARLTTINDRKYTSEVVTLWYRAPEILLGATQYGGAIDIWSTAAIFGELINKEELFKGRCKIDQLFKIFSQLGTPTEDIWNGVTKLPFYLSTFPKWKAKDLHTIFHTDERAVDLLQKMFIYTPEKRISAADALKHPFFDPLNKPNN

Gene
CDC2
Protein
Cell division control protein 2 homolog 1
Organism
Pisum sativum
Length
148 amino acids
Function
Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Mass
17.445 kDa
Fragment
single
Sequence
VVYKARDRVTNETIALKKIRLEQEDEGVPSTAIREISLLKEMQHRNIVRLQDVVHSEKRLYLVFEYLDLDLKKHMDSSPEFVKDPRQVKMFLYQMLCGIAYCHSHRVLHRDLKPQNLLIDRRTNCVKLADFGLARAFGIPVRTFTHEV