CD46

Membrane cofactor protein

392 amino acids

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).

43.601 kDa

MAPPSRRECPFPSRRFPGLLLAALVLLRSSCSDACGPPPTFEAMELTSKPKPYYKVGEQVEYDCKKGYHHFAPFLTHSICDRNHTWLPISDEPCVKKVCHYIPNPLHGEAILANGSYSFGNQLHFICNDGYYLIGKEILYCELKGSDAVWSGRPPICQKIVCKPPPKINNGKHTFSDVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCRDNSLWSDDAPECKVVKCRFPVIENGKQIAGFGKKFYYKATVIFERDKGFHIIGSDTIVCNSNSTWDPPVPKCAKELPPSSTKPPTLSHSVSTSPTTVSPTSSVSGPRPTYKPPVSRYPGYPNPDEGMLNSLDEWAIALIVIAILVGVAIISFGLHRYLQRRKKKGTYLTDETHREVNFTSL

CD46

Membrane cofactor protein

392 amino acids

(Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).

43.747 kDa

MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL

CD46

Membrane cofactor protein

379 amino acids

May be involved in the fusion of the spermatozoa with the oocyte during fertilization.

42.159 kDa

MAPPLHGESRAASWWRILGACLLAAVFLLAASSDACVLPPPFEAMEPINPKPYYEIGEKVEYRCKKGYLRQPFYLMVATCEKNHSWVPITDDGCIKKQCTYLNPPPKGRVEYINGTRTWGDIVHFSCVEGFYVSGIAALSCELRGDNVDWNGRVPTCEKVLCSPPPKIQNGKYTFSDVQVFEYFEAVTYSCDAVQGPDKLSLVGNEVLYCAGHQKWSSAAPECKVVKCPLPVVKNGKQISGLGQTFFYQATVTFQCLPGFYFNGSSTVVCGSDNTWKPSIPECLKGPKPTHPTKPPVYNYPGYPNPREGIFDQELNLWIIILLILIAVVGLALILLCACRFFERKKKSPEKVMPAIQISDHMVNAPILMPSTVQNPMKR

CD46

Membrane cofactor protein

370 amino acids

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.

40.933 kDa

MAPPSRRECPSPSWRFPGLLLAALVLLRSSCSDACGPPPTFEAMELTSRPKPYYKVGERVEYDCKKGYHHFAPFLTHSICDRNHTWLPISDEPCVRKVCHYIPNPLHGEAILANGSYSFGNQLHFICNDGYYLIGKEILYCELKGSDAVWSGRPPICQKILCKPPPKINNGKHTFSDVDVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCRDNSVWSGDAPECKVVKCRFPVIENGKQIAGFGKKFYYKATVIFECDEGFHIIGSDTIVCNSNSTWDPPVPKCVKVSTSPATVSPTSSVPGYPNPDEGMLNSLDEWAIALIVIAILVGVAIISFGLHRYLQRRKKKGKADGTAEYATYQSKSATLAEQRS

CD46

Membrane cofactor protein

369 amino acids

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.

41.07 kDa

MAPPGRRERPFSSGRFPGLLLATLVLQLSSFSDACEAPPTFEAMELIGKPKPYYKVGERVDYKCKKGYFYVPPLATHSICDRNHTWLPVSDEGCYREMCPHIRDPLNGEAILANGSYEFGSELHFICNEGYYLIGKDILYCELKDTVAVWSGKPPLCEKILCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESMIYCGNNSTWSHAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGYYLNGSDKIVCESNSTWDPPVPKCLKGPRPTYKPPVSNYPGYPKPDEGILDSLDDWVIALIVIVIVVAVAVICVALYRFLQGRKKKGKADGGPEYATYQTKSTPPAEQRG

Cd46

Membrane cofactor protein

365 amino acids

May be involved in the fusion of the spermatozoa with the oocyte during fertilization.

40.881 kDa

MTAAPLMPDSTHPCRRRKSYTFFWCSLGVYAEALLFLLSHLSDACELPRPFEAMELKGTPKLFYAVGEKIEYKCKKGYLYLSPYLMIATCEPNHTWVPISDAGCIKVQCTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDINVFKYHEAVSYSCDPTPGPDKFSLVGTSMIFCAGHNTWSNSPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLKGPRPTHPTKPPVYNYTGYPSPREGIFSQELDAWIIALIVITSIVGVFILCLIVLRCFEHRKKTNVSAAR

CD46

Membrane cofactor protein

363 amino acids

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.

39.692 kDa

MMAFCALRKALPCRPENPFSSRCFVEILWVSLALVFLLPMPSDACDEPPKFESMRPQFLNTTYRPGDRVEYECRPGFQPMVPALPTFSVCQDDNTWSPLQEACRRKACSNLPDPLNGQVSYPNGDMLFGSKAQFTCNTGFYIIGAETVYCQVSGNVMAWSEPSPLCEKILCKPPGEIPNGKYTNSHKDVFEYNEVVTYSCLSSTGPDEFSLVGESSLFCIGKDEWSSDPPECKVVKCPYPVVPNGEIVSGFGSKFYYKAEVVFKCNAGFTLHGRDTIVCGANSTWEPEMPQCIKDSKPTDPPATPGPSHPGPPSPSDASPPKDAESLDGGIIAAIVVGVLAAIAVIAGGVYFFHHKYNKKRSK

CD46

Membrane cofactor protein

361 amino acids

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). In case of bovine viral diarrhea virus (BVDV) infection, involved in virus attachment to cells.

39.391 kDa

MRASCTPLKAPLRRPERLASSGRFAWVLLLAPLLLLPTSSDACDDPPRFVSMKPQGTLKPSYSPGEQIVYECHLGFQPVTPGQVLALVCQDNNTWSSLQEGCKKRRCPTLADPTNGQVILVNGSTEFGSEVHYVCNNGYYLLGTNISYCEVSSGTGVNWSDNPPTCEKILCQPPPEIQNGKYTNSHKDVFEYNEVVTYSCDPSNGPDEYSLVGESKLTCIGNGEWSSQPPQCKVVKCVYPAIEHGTIVSGFGPKYYYKATVVLKCNEGFNLYGNSVVVCGENSTWEPELPKCIKGHPPRPTDASPPNGAEGLGAGYIVLVIVAVLIGVGLLLCLYCCFCRQRKKGIYVTGESHRQDILFSL

CD46

Membrane cofactor protein

355 amino acids

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).

39.333 kDa

MAPPGRRECAFPSRRFPGLLLAALVLLLSSFSDACEEPPTFEAMELIGKPKPYYDIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIGDPLNGQAILANGTYEFGYQIHFICNEGYYLIGNEILYCELKGSVAIWGGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSHAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLNGSNTIVCDSNSTWDPPVPKCLKGYPKPEEGILDSLDDWVIALIVIAIVVGVAVICAVLYGYLQRRKKKGNADGGAEYATYQTKSTTPAEQRG

Cd46

Membrane cofactor protein

355 amino acids

May be involved in the fusion of the spermatozoa with the oocyte during fertilization.

39.787 kDa

MTAAPLTPDPTHPRRRRKSYTFFSLGIYAEALLFLLSSLSDACEPPPPFEAMELKDKPKPHYAIGEIIEYTCKKGYLYLSPYPMTAICQPNHTWVPISDHGCIKVQCTMLQDPSFGKVHYIDGRFSWGARVKYTCMNGYYMVGMSVLQCELNGNGDAFWNGHPPSCKKVYCLPPPKIKNGTHTFTDIKVFKYHEAVIYSCDPNPGPDKFSLVGPSMLFCAGHNTWSSDPPECKVVKCPFPVLQNGRQISRTEKKFSYQALVLFQCLEGFYMEGSSMVVCGAKSSWEPSIPQCLKGPKPHSTKPPVYSESGYPSPREGIFGQEFDAWIIALIVVTSVVGVIVICLIILRCSEYRKK

CD46

Membrane cofactor protein

285 amino acids

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).

31.857 kDa

single

MAPPSRRECPSPSWRFPGLLLAALVLLRSSCSDACGPPPTFEAMELTSRPKPYYKVGERVEYDCKKGYHHFAPFLTHSICDRNHTWLPISDEPCVRKVCHYIPNPLHGEAILANGSYSFGNQLHFICNDGYYLIGKEILYCELKGSDAVWSGRPPICQKILCKPPPKINNGKHTFSDVDVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCRDNSVWSGDAPECKVVKCRFPVIENGKQIAGFGKKFYYKATVIFECDEGFHIIGSDTIVCNSNSTWDPPVPKCVK

CD46

Membrane cofactor protein

285 amino acids

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).

31.664 kDa

single

MAPPSRRECPFPSRRFPGLFLAALALLLSSRSDACGPPPTFVAMELTSRPKPYYKVGEQVEYDCKKGYHHFAPFLTHTVCDRNHTWLPISDAPCVKKVCHYIPNPAHGQAILANGTYSFGNQLHFICNDGYYLIGKAILYCELKGSDAVWSGRPPICQKILCKPPPTIKNGKHTFSEVDVFEYLDAVTYSCDPAPGPDPFSLVGESTIYCRDSLGWSGDPPECKVVKCRFPVIENGRQTAGFGIKFYYNAAVMFECYEGFHIIGSDTIVCNSNSTWDPPVPKCVK