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CCZ1A

Gene
CCZ1A
Protein
Vacuolar fusion protein CCZ1 homolog A
Organism
Arabidopsis thaliana
Length
515 amino acids
Function
Plays an important role in membrane trafficking through the secretory apparatus. In complex with MON1, acts as a guanine exchange factor (GEF) for RABG3F of the Rab7 protein family. Promotes the exchange of GDP to GTP, converting RABG3F from an inactive GDP-bound form into an active GTP-bound form. The RABG3F active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles. May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation.
Similarity
Belongs to the CCZ1 family.
Mass
57.84 kDa
Sequence
MASMSSGDESLRLCMFDLRRGQTEGQELEKILFFYPADLDFSTQLSVIGLSEGLITFTRLFSPEAACEVIEAERHSHVFYEAEPDIWMVMVVEKNKETGAIWRIDALRRVLKEVHSLFVMFHGSIRALIEKEPTGGLTRSLLYPFITDYLSTFQIWSLSEDCCCEFFVGKKLQLPTFRETLRERGTVQMLTLARDTAVEVQSLVQVLDSCAGSLRCHSMILFQDLLVSTTLSADDTVDLFTFAVMRLTSKALSSDTSSWSYLRKGPGSSEISSRSNLAPVGSIDSLHSRNGNNMHHVIRPLQNDKWTKGKDGFLITDIWGLETGGSPDSAIPTIWLQQTQERMYLLAYQHKSLTLLLLMPTNAIVNGDLSISAVKQQVIEDASLRILKIEENISRGWGGENAYHIKGYRYLVVDNDTKVSRSSPSGKVTTLAKESLLALNKLREEVDSEKSRAKGQEKDMEICIRAKNNVWVIARVTRGKELYMALEKGSDTLLDTTDAVGRFSNRYCSGAFLMD