CCZ1

Vacuolar fusion protein CCZ1

704 amino acids

In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.

Belongs to the CCZ1 family.

80.732 kDa

MRLHYITVFDPSRSTNENDTFKQLLLFHYFGTTDSIPSLNEKLSIIGVIQGIWSLTSSCVNKDGEDLEKIIELNNDIIFCIKVESRFFISLAISNISDDQSAIPLQYLSAYLWLSYRFFKLLNGSFSGFNKDFRKLTDLLNEFVIPFWNDIYLNLETVTNRSFTVMWPGFYKRANFQHSSYNPGEKNNVEESWDAIILQNILLDKKSYLGLKDILVYHLPKRTKAANRESMGTKTYGLVRNFTSDLNTLPDISNWLYHLHCTYGEISSHILTGNVHFKEELQVEEEQERSRDTNGRDEEESQEQQRREHQETTQNNTSELSLSERVIHNVTLPISFAYDAIHEVSTTTGVSGSLSMIMDYVPKPHWPFISSSNKSADKNNYSNSNDNANSNAPLMAQSEAVGGTIGNSRFGFLISPLNSDLLPSSYQALKLNLNFENSKDKEDFYNCLFWYFDDFLIVIVCDPDFNKICERDYLKDLSFQLCQSMECLNNEILNSQNCDNVESFAYVIRDNVTKEIDSSVPFGSPKFTSDESISTLQLAINGIDQFINDNSNSLSLANWNPITIMGGSNAISKKNTTEGFGNGVNDKTQKFKRKYLNFLNLMSAEKLWDLQVDVLQFLTSLQNSKRDPDYFQEERLLKLNNGVLCYIKENNSNLIIIIKNWFQNNGTSKAAKQRNRFSSDSSKGSSLFQSLGRDVTDWWESREI

CCZ1

Vacuolar fusion protein CCZ1

679 amino acids

In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.

Belongs to the CCZ1 family.

78.35 kDa

MSQSQSHGSGSPLKYVIVFRPGENKGEQEDSVVSEQLLLHHAFEDTELITLSAKLGKIGIIQALWTLSEDTNDTCKIIETEQETMITIKVEGEFYITLAIGVDPDLLAIPNPIFEGHLWNCYHFFTIKYGDFTSFEKHVLTDLLNEHFVSFWNDLYRKPESLTRNFLQYLCHDFYKVADLDPNGDKQWEATIIQDLLVQTENYLGIKDILVYNIPSTESTYVGKCKYGLIRNFCNEFEDLGHFSNWLQHIHTVFGKISSHVLAENVHYELHSGQLEQTNSDGIRDGNDLNLSDNNNETDSNTFSQLSTNFMHNLTLPITFAYDAIQEVGNTTGINNSVSLFMNYLPKWQNNSTASENEKNKTKARYGYLISPLAFDSLPKSYKLKKMHLKFNGEERKPYHVLFWYYNDVLVVIICNESFDSIWSKEYLNELNKHLENSIKTLYDQNLYDLPNTDNHSNKKNDILNFAYLITDKKRNKLYSSFPDLSWFNEQQETLYRTTLELVSNGLEQLRPQITANELSITTIDSNKQWGLDIMGNILSMLPSNSPVPVTKDASIPLMKKLNFLDKLNEKVLRDISIETLRAIETLSQSINSNIQEEKLLKTSDGILLYIRNDCNNLTIILKNWIQDTKHQTRALKYKNHTLNSYSTSIEDSNLFKNLGPDVISWYSEYKQILQDDSS

CCZ1

Vacuolar fusion protein CCZ1

663 amino acids

In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.

Belongs to the CCZ1 family.

76.332 kDa

MDFIAVYNPAVYAKEADSEAWRQLLLYHSFKEDAEEPTPQNEKLSLIGMIQGIWQFAHNFSEPETRGSVRYVDTQLERRRVIAVEVEDGHFMAFGVEDGKRYGCEYYVRELLQSYHVFRLHCGSMSEFADRGELTDRLNEHVVGYWQALKLVPEAIYASTLASVCWHDGYKVSELELRDRAWESYIKNEILLDSESFLGLKDMCIYKLPRDGRRSAAEYGLLRSFAPEFLSLPELSNWVYHLDRLFETALSSHVLAGHVRLSIGGDEQEEEGELRHDSQPASDVGARMWRNVTMPISMTYDTMSEVGNLTGINTLMSGLNSLTSGFSSMTSRLVRRADRQNSDTASLSLHVDHGFLISPLALEALPESYRYRRFQLRFSTDEPQWYRLLFWYYKDYLCIFIFHENFDKIWDPDYLQAIDAKLYDAMLQLEGSVVTEDNKPGRFAYGVFNKTTKRIECSLPLLRFSDKRSDEKSRQPLKMVVAGIDETLQFLTAGTFATNMATSRTNDEHMGPSATNTLRMPEPTDAPSSSWTLDITKLNLFQGLNENLRLEKMADTDSGTFLDSLSSEKLLQLNVELCRLYTGIRRSEYNKAGIQEEQLLRLNNGILFYISTSPTEDVLILKNWFMDDKYTKAENKRSTSASLLHSLGGDVRRWWNARTNREQ

CCZ1

Vacuolar fusion protein CCZ1

618 amino acids

In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.

Belongs to the CCZ1 family.

71.655 kDa

MSVQFIVLFRDDDDNKDDSCKLLLYHDLTAHMLSTNEKEQKIGIIKGMWRFSNEFSQSNDYCHVELDSYSMLVLEVEPSYYLALGFENTHNSQWPKYKVRLSQCYQFFAMQHGKMQDIEDKTLSGLLNEHFIPFWDEINLIPDYFLMQDINTAIDDKMFPCCQFADALNSISEVKDWQNYLKNNVLLSEENYLNIKDVCVYHLPKNNKNTKEYGFITNFDPQFKSLPTLSNWLVGIDSMYGTVSSHGLAGTMSLTETEQQIELDAEEAHHEQPPNIKTVWDNVTLPITFTMDALKDIGQLTGVSNSLSLFTNMKPSWNLWSSSSENGAGSAKLDDKDEYSWLISPLNPSFLPKVYQMRKFYLQFDDWSQYNILFWKFKDVIVAVIVDPSFKKISEESFLMKLQEELWNGISLFYENTGFEKRQCSFDYTILFKEEGKYYSSIPRWKNGLDESDTALKLVIKGLDETLQFLTNNANRKSSVATVTEVGHDMSLTDHPIPSDPSKGEDGTEKTDKSESSIFSKLNESQLVELNKELMVILGTRSLTVWYKDANTKERMLKLNNGLMVYLLENNRKLVLIIKNWFIDSQQKTKSKRSTDMIESLGKDVSTWWNRIKDHEPL

CCZ1

Vacuolar fusion protein CCZ1 homolog

492 amino acids

Plays an important role in membrane trafficking through the secretory apparatus. In complex with MON1, acts as a guanine exchange factor (GEF) for Rab7 protein family. Promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. The active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles. May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation.

Belongs to the CCZ1 family.

54.85 kDa

MGLSSAAAGEGPQLCVFDLRRGQQEGQELDKILFFHPTDCPILLQLSVIGLCEGIITFARIFSPDDDCEVIESEKHSHVFYQAEADIWMVLVVEKNKDIESTWRCGALQGILKEVHSLFTMFHGPIRTLLDRQPSAELARGHLRTFFTDYLSDFNAGKKIQLPTFRDCLKERGTVQMLTISREVALEVQSLTTVLGSCLGNVMCQSLVLFEDLLVSTTLPPDDTLNLYTYAILRLTPRALLSNATSWSYLRKGTSVHAGPTSSSSNGTASVERPLQREKLYKGKDGFVAAGSTTSEVRGAVAWVPILWFQQAEDRMHLCVYQHKNITILLLIPASSLINGDDGIAHVKRHLLENASQNIVTLELKLSRGWGGENAYHVGGYRYLLVDPDRKVSRASPPGKVTTLSKDSLLSLNRLREEIDLEKSRAKRSDSCHDKDFEVCIRAKNNAWVIAKVTRGRELYMALEKAGETLLYASTAIEKFSNRYCEGAFSTD

CCZ1

Vacuolar fusion protein CCZ1 homolog

482 amino acids

Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991).

Belongs to the CCZ1 family.

55.866 kDa

MAAAAAGAGSGPWAAQEKQFPPALLSFFIYNPRFGPREGQEENKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWMVMVVRNPIIEKQSKDGKPVIEYQEEELLDKVYSSVLRQCYSMYKLFNGTFLKAMEDGGVKLLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLNIVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPIRAEMPGNLQHYGRFLTGPLNLNDPDAKCRFPKIFVNTDDTYEELHLIVYKAMSAAVCFMIDASVHPTLDFCRRLDSIVGPQLTVLASDICEQFNINKRMSGSEKEPQFKFIYFNHMNLAEKSTVHMRKTPSVSLTSVHPDLMKILGDINSDFTRVDEDEEIIVKAMSDYWVVGKKSDRRELYVILNQKNANLIEVNEEVKKLCATQFNNIFFLD

CCZ1

Vacuolar fusion protein CCZ1 homolog

480 amino acids

Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form.

Belongs to the CCZ1 family.

55.502 kDa

MAAAASGAGAGAAQEKQFPPALLSFFIYNPRFGPREGEEENKILFYYPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWMVMVVRNPIIEKQSKDGKPVVEYQEEELLDKVYSSVLQQCYSMYKLFNGTFLRAMEDGGVKLLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLSIVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPIRAEMPGNLQHYGRFLTGPLNLNDPEAKCRFPKIFVNTDDTYEALHLIVYKAMSAAVCFMIDASIQPTLDFCRRLDSIVGPQLTVLASDICEQFNINKRMSGSEKEPQFKFIYFNHMNLAEKSTVHMRKTPSVSLTSVHPDLMKILGDINSDFTRVDEDEEIIVKAMSDYWVVGKKSDQRELYVILNQKNANLIEVNEEVKKLCATQFNNIFFLD

ccz1

Vacuolar fusion protein CCZ1 homolog

480 amino acids

Belongs to the CCZ1 family.

55.895 kDa

MLMISPRMASGMQEKQYTPSLLSFFIYNPKFGPREGEEEKKILFYHPIEIEKNEKIRNVGLCEAIVQFTRTFCPTKPAKSLHTQKNRQFFHEPEENYWMVMVVRNPMVEKPNKDGKPPTVEYQEEEIIDSVYGSVLQQCYSMYKLFNGTFSRAFEAGGVELLTQKLEKFFYRYLQTLHLQSCDLLDVFGGISFFPLDKMTYLKIQSFVNRVEESLSLVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHTEPELAGRDSPLRPEVAGNLLHYGRFLTGPANLKDPEAKFRFPRIFVNTEDSCEELHLIVYKAMSAAVCFMINASVDLNREFCEKLDSLVGPQLTLLASDICEQYNINRRISGPEKEPQFKFIYFNHMNLAEKSTIHMRKMASVSLTSVHPDLMKILGDINCDFARVDEDEEIIVKAMTDYWVVGKKSDQRELYVILNQKNANLIEVNEEVKRLCATQFNNIFFLD

Ccz1

Vacuolar fusion protein CCZ1 homolog

480 amino acids

Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form.

Belongs to the CCZ1 family.

55.505 kDa

MAAAAAGPGAWAAQEKQFPPALLSFFIYNPRFGPREGEEENKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWMVMVVRNPIIEKQSKDGKAVVEYQEEELLDKVYSSVLQQCYSMYKLFNGTFLKAMEDGGVKLLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLSVVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPVRAEMPGNLQHYGRFLTGPLNLNDPEAKCRFPKIFVNTDDTYEELHLIVYKAMSAAVCFMIDASTPLTLDFCRRLDSIVGPQLTVLASDICEQFNINKRISGSEKEPQFKFIYFNHMNLAEKSTIHMRKTPSVSLTSVHPDLMKILGDINSDFTRADEDEEIIVKAMSDYWVVGKKSDQRELYVILSQKNANLIEVNEEVKKLCATQFNNIFFLD

ccz1

Vacuolar fusion protein CCZ1 homolog

480 amino acids

Belongs to the CCZ1 family.

55.724 kDa

MQMISPRMASGMQEKQYTPSLLSFFIYNPTFGPREGEEEKKILFYHPSDVEKNEKIRNVGLCEAIVQFTRTFCPTKPAKSLHTQKNRQFFFEPENNFWIVMVVRNPMIEKPNKDGKSQTIEYQEEEILDTVYGAVVRQCYSMYKLFNGTFARAMETGGVELLMQKLEKFFYKYLQTLHLQSSDLLDVFGGISFFPLDKMTYLKIQSFVNRVEESLSLVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHTEPELAGRDSPLRPELAGNLLHYGRFLTGPLNLNDPEAKFRFPKIFVSAEDGYEELHLIVYKAMSAAACFMISASVELTRDFCEQLDKLVGPQLTLLASDICEQFTINRRISGPEKEPQFKFIYFNHMNLAEKSTIHMRKTASVCLTSVHPDLMKILGDINCDFARVDEDEEIIVKAMTDYWVVGKKSDQRELYVILNQKNANLIEVNEEVKKLCATQFNNIFFLD

CCZ1

Vacuolar fusion protein CCZ1 homolog

476 amino acids

Belongs to the CCZ1 family.

55.208 kDa

MATAAAAGAGQEKQLAPTLLSFFIYNPKLGPKEGEEEKKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPTKPAKSLHTQKNRQFFHEPEENFWMVMVVRNPIIEKHKDGKPVYEYQEEELLDKVYSSVLQQCYSMYKLFNGTFLKAMEDGGVKVLKERLEKFFHRYLQTLHLQSCDLLDVFCGISFFPLDKMTYLKIQSFINRMEESLNIVKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHMEPELAGRDSPIRAEMPGNLQHYGRFLTGPLNLNDPEAKCRFPKIFVNTDDTYEELHLIVYKAMSAAVCFMIDASIPPTLEFCRKLDSIVGPQLTVLASDICEQYNINKRISGAEKEPQFKFIYFNHMNLAEKSTIHMRKTPSVSLASVHPDLMKILGDINSDFSRVDEDEEIIVKAMSDYWVVGKKSDQRELYVILNQKNANLIEVNEEVKKLCATQFNNIFFLD

ccz1

Vacuolar fusion protein CCZ1 homolog

471 amino acids

Belongs to the CCZ1 family.

55.122 kDa

MAFAGQDKRYAPSLLSFFIYNPKFGPREGEEEKKILFYHPNEVEQNEKIRNVGLCEAIVQFTRTFNPTKPAKSLHTQKNRQFFHEPEEGFWMVMVVKNPVAEKQKDGKTVLEYQEDELLDKVYSSVLQQCYRMYKLFNGTFGRAMEVGQVELLKDRLEKFFHRYLQTLHLHSCDLLDVFGGISFFPLDKMTYLKVQSFINRIEESLNIVKYTAFLYNDQLIWSGLEQEDMRILYKYLTTTLFPRYTEPELAGRDSPIRPEMPGNLQHYGRFLTGPLNLNDSEVKFRFPKIFVNTEDSYEELHLIVYKAMSASVCFMIDASVQLTVDFCRKLDSLVGPQLTVLASDICEQYNSNRRISGSEKEPQFKFIYFNHMNLAEKSTIHLRKTPNMSLTSVQPELMKILGDINSDFTRVDEDEEIIVKAMSDYWVVGKKSDQRELYVILNQKNSNLIEVNEEIKKLCATHFSNIFFLD

ccz1

Vacuolar fusion protein CCZ1 homolog

471 amino acids

Belongs to the CCZ1 family.

55.218 kDa

MAYAVQDKRFAPSLLSFFIYNPKFGPREGEEEKKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFNPTKPAKSLHTQKNRQFFHEPEEGFWMVMVVKNPLAEKQKEGKTVLEYQEDELLDKVYSSVLQQCYRMYKLFNGTFSRAMEVGQVELLKDRLEKFFHRYLQTLHLHSCDLLDVFGGISFFPLDKMTYLKIQSFINRIEESLNIVKYTVFLYNDQLIWSGLEQEDMRILYKYLTTTLFPRYTEPELAGRDSPIRPEMPGNLQHYGRFLTGPLNLSDPEVKFRFPKIFVNTEDSYEELYLIVYKAMSASVCFMIDASVQLTVDFCRKLDSLVGPQLTVLASDICEQFNINRRISGSEKEPQFKFIYFNHMNLAEKSTIHLRKTPSMSLTSVQPELMKILGDINGDFTRVDEDEEIIVKAMSDYWVVGKKSDQRELYVILNQKNSNLIEVNEEIKKLCATQFSNIFFLD