ccdc88c

Daple-like protein

2058 amino acids

Positive regulator of Wnt signaling, acting synergistically with dvl2/dsh. Functions upstream of ctnnb1/beta-catenin in the canonical Wnt pathway, and also activates jnk in the Wnt/planar cell polarity (PCP) pathway.

Belongs to the CCDC88 family.

236.339 kDa

MDTTISQQMDHFLESPLVTWVKTFGPCGNENESKLAMYMELVDGVFLNKIMVQIDPRPSNQRVNKHVNNDVNRRVQNLTILVRHIKAYYQEVLQQLIVMNLPNVLLISKDPLTDKSMEELKKILLLMLGCAVQCERKEEYIERIKQLDIETQAGIVSHIQEVTHNQENVFDLQWLELSDMAPEELDSLSRNMALHLKRLIDERDECKEVIVDLTQERDYLQFQNHPSPVKSSSPDTSANMVSHLSSEDKKHLAVELAESKAKLRRIRQELEEKSELLLDTKHEVERLNLELQKIKQENFQLASEARTARTYRDEIDSLKERASKVDRLENELARCKEKLHDVDFYKARMDELREDNMILIETKSMLEEQLAAARTRTDKLHELEKENLQLKSKIHDLELDRYSDKNRIEELLEENMVLEIAQKQSMNESAQLGWELDQLSKSTDLSDARKSFVFELNETTSSKILKLEKENQSLQNIIQDLREASLTLEEGNLKGQEWEKENQQLSKKIENLNQQIERERQSSLDLESLSEDLLKEKDQLSQALENIKSQKERQIKELEQENKHLIQTLEAVRQRSQVSTEARVKDIEMENRILHETIKDTSSKMNELEYEKKQLQKAFDQSKEQVEKLDKMEKEVHRLEKQNEILTKKVTSIKIVEEKMQGLEKENEVLEGENIVLKKSLDTLQNVTIKLEVLESENKQLDEENLELRRAVEAMRFSCAKSTQIERENNELQKEKEELQKNVELLKALGKKSERLEVSYQGLNDENWRLQQMLDTGNKKINDLEKELHDTEKENKDLQRTLEEMKICNKRLERMEEENKAKEQEMVQLEKDNKILQKESKRLWQQVELKDAILDDNTVKLADLEKENRALEKEISKLRDLSTKTRDLERENKDLLQQMTVDKRTLATLREDLVLEKLKTQQMSSELDKLSLELEKIGLNKESMLQDENSNAEKKYKLLENKIESTLKTTLAVKENKIVALEMKIEETSSLNQQLQNELNSIKKDIIASKENLRGAAHNSYTQLSSKQDCNSQINGQRETTVELLKFKDRTIELERNNAALQAEKKLFREQLQHLESHNLNLSSQMGTLQKQVTFLQEHNTALQTQTANLQVENATATSQVASLKSQISQFQNQLSARESENEILQQQKEHLRVTHESLLQDHEQLGSLYERQSAEYEGMISQHSSLKSQYKSLEQAHRSLEESYSTLIKHKKELEDLDAVLKKEQDVLQQERRKNFVAMEENQKLKTDLERLNFLHGELQTEYSSLHKHTKEVKTSLNNAQMELNRWQARFDELKEQHQTMDISLTKLDNHCELLTRLKSNLEEENHHLLSQIQMLSQQNQMLLEQSMETKEQYHEEQKQYIDKLHDLRRQKEKLEEKIMDQYKFYDPTPKKKSHWSGAKAIAKLIKPKKEPSRESVKSPTDVQSKTMDNAEMAASPSSMRPLRLQQESLDNSSLGSDEKGSPKVLASKVLVEVAQRQHRMSYHGSSSEQTDGPEHLSRSRRMESGSRAFSTSTIHLTAPAHNAKVPHLSRPKGYNSDDNQSDQLHEAESNAGSSRVPWTSSLEVSRSASNSSSPLTLKGRPESVSSEDMIPTKDIATLSRESNLYHPNAVMLGATKNRESPVNRNSLHLYDYPEKKNSSRTPTRPRPGSPGSEMVTLEEFLQESSRQSPPSRRHSLNDSELITLHQFLFEAETLHPSSQSPSPTLHLKDPSQTAVPKSLPSAENCEWRKRADRASRRAASLYIPRDMVTNRDDMLGDLFKKTEDPPDIRSPMSELIFKDAAQMPTSYVSPTVKVTGNTTKPGQYVKPHPRQLDAPLNVTSSLLHQANVYSATSSSQSPEPQALSPHGAMGSRGNSLSRAFSLASADLLKENGPEVVMQEKSDVETPVGKDFGRYMIRSSTPLGSQSSLREKPQSARMQHMLRGDDRQYRSLDSRRLSLALPKEETTPPQPAPSASSLQQHYTLGHGAIRGKPKLLSRSGEVALVSPVRPISSIPELETTQGLASAGPGKSRSTSPDCSPAPVCEEEPNKSETLKSTPASPDPSADPQTVWYEYGCV

CCDC88C

Protein Daple

2028 amino acids

Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway (PubMed:25062847).

Belongs to the CCDC88 family.

228.23 kDa

MDVTVSELLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQRINKHVNNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPAASQPLRSQAENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKRGSPHRGSLDRTDASTDLAMRSWPSELGSRTCSTSATTTAPSNSTPIARHPGRTKGYNSDDNLCEPSLEFEVPNHRQYVSRPSSLESSRNTSSNSSPLNLKGSSEQLHGRSESFSSEDLIPSRDLATLPREASTPGRNALGRHEYPLPRNGPLPQEGAQKRGTAPPYVGVRPCSASPSSEMVTLEEFLEESNRSSPTHDTPSCRDDLLSDYFRKASDPPAIGGQPGPPAKKEGAKMPTNFVAPTVKMAAPTSEGRPLKPGQYVKPNFRLTEAEAPPSVAPRQAQPPQSLSLGRPRQAPVPPASHAPASRSASLSRAFSLASADLLRASGPEACKQESPQKLGAPEALGGRETGSHTLQSPAPPSSHSLARERTPLVGKAGSSCQGPGPRSRPLDTRRFSLAPPKEERLAPLHQSATAPAIATAGAGAAAAGSGSNSQLLHFSPAAAPAARTKPKAPPRSGEVATITPVRAGLSLSEGDGVPGQGCSEGLPAKSPGRSPDLAPHLGRALEDCSRGSVSKSSPASPEPGGDPQTVWYEYGCV

Ccdc88c

Protein Daple

2009 amino acids

Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (PubMed:14750955). May also activate the JNK signaling pathway (By similarity).

Belongs to the CCDC88 family.

226.535 kDa

MDVTVSQLVELFLQSPLVTWVKTFGSFGSGHQDNLTLYMDLVDGIFLNQIMLQIDPRPSNQRINKHVNNDVNLRIQNLSILVRNIKTYYQEVLQQLIVMNLPNVLMIGKDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLDLPDVAPEELEALSRNMVFHLRRLIDERDECTELIVDLTQERDYLQTQQPPSPGKFSSPDSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVERLEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYEELHAHTKELKTSLNNSQLELSRWQVRFDELKEQHQSMDISLTKMDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMESKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPAPKKKNHWIGAKALVKLIKPKKEGSRERLKSTTDSPPWQLEPSDPASPSPSQALRSQTENPDNPPSGPNCVEERDTHNGPVGKGPGDLKPKRGSPRGGSVDRTDTSTDPAVKSWPSEPGSRTFSTSATTAALSSSTPIPKHLGRTKGCNSDDNLCEPSSEPDGPYHRQQASRPNSLESSRNASSNSSPLSLKGSSDHLHSRCESFSSADLIPSRDPATLSRDGNTSGRGLLGRHEYPPPRNGPVSQETIQKKGAASTHTGVRPHSASPSSEMVTLEEFLEESNRGGSPTHDTPSCRDDLLSDYFRKAHDPPALGGQPGPPARKDGAKMPTSFVAPTIKMSINTSEGQQLKPGHYVKPNLRPSEAEALAGMPSRQVQPPQSLSLGRPRQTTMTQNCHMPVSRSASLSRAFSLASADLLRASGPEACRPESPQKPGGHEAAGARETSTHSLQGSHILARERTPIVGKADSPSPGQGTRGRPLDTRRFSLAPPKEERLAPLQQSATAPALATGCSSGSNPQIQHFSPTVAPAVRTKSKVPQHSGEVATVAPVRPGLGTSEGDGGPGHGYSEGLLTKSPGRSSDLPPHVKRGPDDFSQGSSSKSTPASPEPGGDPQTVWYEYGCV