Ccdc8

Coiled-coil domain-containing protein 8 homolog

685 amino acids

Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome.

73.938 kDa

MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLIQFLQEEGRTLEDVARIIEKSTPHPPQPRKRTKELRVRRVPQMVTPPLRLVVGTYDSSNGSDSELSDFDTSKVKGNRSSSGRTRKVRKMPVSYLGSKFLGSDVESEDDQELVEAFLRRGEKPSAPPPRRRVNLPVPMFENNLGPQPSKADRWREYVSQVSWGKLKQRVKGWAPRSGSEVGQTQQASTAAERAGEMRHSQASSDDDSSRNTGDRSDQMLGTRRWKPKIKWVSLRRCRKEQVPPFAQGTGMPAEEHPEAAENQGAEAAANQRAEPLASPRAEAAASPRAETAADPRVEAVASPRAEAAASPRAEAVADPRAEAAASPRAEAAASPRTEAAASLRAEAVASPRAEAAASPRAEAAADPRAEAAASPIAEAAANQKAELVDSPRAETAADPRAEAAASPRAEAVADPRVEAAASPIAEAAANQKAELVDSPRAETAADPRAEAAASPRAEAAADPRAEVAASPRAEAAASPRAEAEASPRAEAAASPKAEAEANLRVEAAAYLRAGVPPDQRAEAIDSQRAEGPANQRTGATENQRVEVLADQRAGVLHDQREEAGPQGIQEASAGSGSRAQKQVKTVRFQTPGRFSWFRMRRRVFWHTPRLPTLPRRVPRAGEARSLRVLRADIRADVEHREQEEQL

Ccdc8

Coiled-coil domain-containing protein 8

643 amino acids

Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome.

69.589 kDa

MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAVFRERLIQFLQEEGRTLEDVARIIEKSTPHPPQPPKKAKVPRVRRVPQMVTPPLRLVVGTYDSSNGSDSELSDFDTSKVKGNRGSGKTRKVRKMPVSYLGSKFLGSDESEDDQELVEAFLRRGEKKPSAPPPRRRVNLPVPMFENNLGPQPSKGDRWREYVSQVSWGKLKQRVRGWAPRSGSEVGQAQQSSIAERAGEMRHSHTSPDLDDSSRNTGDLSDQTLITRRWKPKIKWVSLRRCRKEQVPPLAHGTAEEPPEAAENQGAGAAAEHGVEAAASQRPEAAASPRAEAAANPRAEATANPRAEAAANPRAEAAASPRAEAAANPRAEAAANPRAEATANPRAEAAANPRAEATANPRAEAAVNPRTEAAVNPRTEAAANPRAEAAVNPRAEATASPRAEAEVNQKTEATASPRAETAASPRVEAAASLRVEAAASPRAEATVSPRAEAVATPRAETAASARVEAAANLRAGVLPDQRAEAIDSQRAEGPVNQSTGATENQRVEVLADQRAGVLHDQREEAGPQAILEASADSGSRARKQVKTVRFQTPGRFSWFHMRRKAFWHTPRLPTLPKRGPRAGAGEARSLRVLRADTRADMEHREQEEQL

CCDC8

Coiled-coil domain-containing protein 8

538 amino acids

Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695).

59.374 kDa

MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLTQFLEEEGRTLEDVARIMEKSTPHPPQPPKKPKEPRVRRRVQQMVTPPPRLVVGTYDSSNASDSEFSDFETSRDKSRQGPRRGKKVRKMPVSYLGSKFLGSDLESEDDEELVEAFLRRQEKQPSAPPARRRVNLPVPMFEDNLGPQLSKADRWREYVSQVSWGKLKRRVKGWAPRAGPGVGEARLASTAVESAGVSSAPEGTSPGDRLGNAGDVCVPQASPRRWRPKINWASFRRRRKEQTAPTGQGADIEADQGGEAADSQREEAIADQREGAAGNQRAGAPADQGAEAADNQREEAADNQRAGAPAEEGAEAADNQREEAADNQRAEAPADQRSQGTDNHREEAADNQRAEAPADQGSEVTDNQREEAVHDQRERAPAVQGADNQRAQARAGQRAEAAHNQRAGAPGIQEAEVSAAQGTTGTAPGARARKQVKTVRFQTPGRFSWFCKRRRAFWHTPRLPTLPKRVPRAGEARNLRVLRAEARAEAEQGEQEDQL