CCDC36

Interactor of HORMAD1 protein 1

594 amino acids

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

66.343 kDa

MNFNVWNIKEMLSIPSGSGNKKSSNWNNNQNDYSSLSDSQFLFGSQFCPENSETLSAPLDFGAHLRHSKQSQQNYLEGEPSIFTKYQTKPQLFGGDIKDGGLFPPPLSVGKSKGLLEQFEEKKKRAKDKCDSETLYNFVSNVRESILRLQTSVEKSEDHLSSRSQSILDSLETVAKTLQETIQAQNDLVFEAVQDKGNMEQAILEMKKRFEARQGEFIEMKSNLKHLEVLVAQQSQEFQQLCEQLGQLNVPSVLAELKRLISVPPVKDSASQTSPPLAQSLNLTRQEKYTSEKPVLWQAQALPAAWNPGMGSLQPGEFDVWGEGAKNDDLQEEAALPAFGSHERNRHVKDKVVQTNCKNWAVTKTGAKNHGSSVPGHKIPSDRDLVSQGASQLTSLEINFSTSIKNACQKYQAQSMFLCDPREHLVIKQKDGTVEMRGKDKKQQPRKAHRAHRGRLIASKQKQIPIQTCKFNSKYQSPQPAISVPQSPFLGQQEPRAQPLHLQCPRSPRKPVCPILGGTVMPNKTVRAVQGRLLQLSRCSSQDNWLLSSSSQGDHQMSWFSDLNLGCSETPLCKEAGKNLLYDLGFDSSDDDGF

Ccdc36

Interactor of HORMAD1 protein 1

574 amino acids

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:27723721). Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721). Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance (PubMed:27723721).

63.34 kDa

MNFNVWNVKEMLSIPSGSGITKPSNWNNNQTDCSLSDSQFLFGSQFCPENSETLLPSLDAGACLRHPKQTQQNSVDSEPSIFIKYQAKPQLLGGDTKDESLFSLPLPVGKSKGLSKQFEEKKRRATDQSDSETLHSFVSHFPEVINKLQTSVEKTEENLSSRSQSILDSVETIAKTFQETARVQHDLMVESVRDKGSMEQAILEIQRTCAARQAEFMEMKSTLKNLEVLVVEQTKNLQQFCDNLSQLIVPGILEELKKFTSVPQVAGHLKDSTSQTSPSLTQSLHFTRQEKHPSEEPATWQAQEAPAGNPSTSSQRPGECGVWDEGAESGVFQKAALPTDGLHRGDGHVKNKTVPTYCKNWVMTTRSVSNHFSNLPSQRAGNGQGLMAQGASQRDVSKFEARVKNACPEYGPQSMCSFDSLEQSATEQKGRPCRKRRRGKKQQPQRSKRGGLLDRKQGQTSKAACAFIARHHCPQSPVCDPQGPLICWLTPRSSTKSTCHILGGTGETSQTARAAQGNLVQHSQRSSTDSSSQGDQQINWFSDLSLENLEPPQCKKGGTNLLCDPDFDSSDDNF