CBF1

Centromere-binding protein 1

359 amino acids

Required for chromosome stability and methionine prototrophy. It is involved in chromosomal segregation. Binds to a highly conserved DNA sequence (5'-RTCACRTG-3'), called CDEI, found in centromeres and in several promoters (By similarity).

39.826 kDa

MSGKRSYQDDQLDVEEANKRHQMVDTLLRGSEDKDGDNDNSVYDDLLQDPEEVEKENKENRDGDKVGDDEHDVVKGESEGQAAEQSSADQNDENINVDVDPSVTAVARAAQHASQRREAGDEDEDEDEEEEEDEDDHVDIDDVDKDPDAVIDEDDDEEDEDQAQRRRGKKNIEGTGESNDSERATKIGESGSSNETAGADGSGDREDGSQPDGTEHDDEENGGAGAGGAAPRRGRKPGTETGSTAWKQQRKESHKEVERRRRQNINTAIEKLSDLLPVKETSKAAILSRAAEYIQKMKETETANIEKWTLQKLLGEQQVSSLTSANDKLEQELSKAYKNLEELKKKLKEAGIEDPTEEE

CBF1

Centromere-binding protein 1

351 amino acids

Required for chromosome stability and methionine prototrophy. It is involved in chromosomal segregation. Binds to a highly conserved DNA sequence (5'-RTCACRTG-3'), called CDEI, found in centromeres and in several promoters. DNA-binding activity is enhanced by MET28. Required as an auxiliary factor for transcriptional activation of sulfur metabolism together with MET4 and MET28.

39.388 kDa

MNSLANNNKLSTEDEEIHSARKRGYNEEQNYSEARKKQRDQGLLSQESNDGNIDSALLSEGATLKGTQSQYESGLTSNKDEKGSDDEDASVAEAAVAATVNYTDLIQGQEDSSDAHTSNQTNANGEHKDSLNGERAITPSNEGVKPNTSLEGMTSSPMESTQQSKNDMLIPLAEHDRGPEHQQDDEDNDDADIDLKKDISMQPGRRGRKPTTLATTDEWKKQRKDSHKEVERRRRENINTAINVLSDLLPVRESSKAAILACAAEYIQKLKETDEANIEKWTLQKLLSEQNASQLASANEKLQEELGNAYKEIEYMKRVLRKEGIEYEDMHTHKKQENERKSTRSDNPHEA

CBF1

Transcriptional regulator CBF1

251 amino acids

Transcription factor that binds ribosomal protein gene promoters and rDNA locus with TBF1. Necessary for the expression of genes involved in assimilation of inorganic sulfate. Also required for the expression of respiratory genes and glycolytic genes. Does not bind to centromeres and is not necessary for efficient chromosome segregationas as does S.cerevisiae CBF1.

29.153 kDa

MVKSHKRTLEKDEEHQEKKKANKISKDDMEIDAELLTQQASDSAHTDTATAAVAAVNNEQGKELEQTESSTNQTSALDKDDKETKDNLNPREETQSSHQEIDIPKDQLTNQQNLADQHQQYQYHQQLAQTNFKTEPTNSAKPPHGSEEWHRQRRENHKEVERKRRESINTGIRELARLIPTTDTNKAQILQRAVEYIKRLKENENNNIEKWTLEKLLTEQAVSELSASNEKLKHELESAYREIEQLKRGKK