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CAVIN3

Gene
Cavin3
Protein
Caveolae-associated protein 3
Organism
Rattus norvegicus
Length
263 amino acids
Function
Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). Seems to have an immune potentiation function, especially in the glioma (PubMed:15197346).
Similarity
Belongs to the CAVIN family.
Mass
27.91 kDa
Sequence
MGESALEPGPVPGAPAGGPVHAVTVVTLLEKLATMLEALRERQGGLAERQGGLAGSVRRIQSGLGALSRSHDTTSNTLAQLLAKAERVGSHADAAQERAVHRAAQVQRLEANHGLLVARGKLHVLLFKEETEIPARAFQKAPELLGPEDQLVLGPEQPEDEVGESSDEEPVESRAQRLRRTGLQKVQSLKRAFSSRKGSEAAQPTPVKPPRLGPVRNSEGPAEGQPAAQPAMEPVLPSALEPEPPQPTKEDPERPVLQIESAA

Gene
Cavin3
Protein
Caveolae-associated protein 3
Organism
Rattus norvegicus
Length
263 amino acids
Function
Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). Seems to have an immune potentiation function, especially in the glioma (PubMed:15197346).
Similarity
Belongs to the CAVIN family.
Mass
27.91 kDa
Sequence
MGESALEPGPVPGAPAGGPVHAVTVVTLLEKLATMLEALRERQGGLAERQGGLAGSVRRIQSGLGALSRSHDTTSNTLAQLLAKAERVGSHADAAQERAVHRAAQVQRLEANHGLLVARGKLHVLLFKEETEIPARAFQKAPELLGPEDQLVLGPEQPEDEVGESSDEEPVESRAQRLRRTGLQKVQSLKRAFSSRKGSEAAQPTPVKPPRLGPVRNSEGPAEGQPAAQPAMEPVLPSALEPEPPQPTKEDPERPVLQIESAA

Gene
CAVIN3
Protein
Caveolae-associated protein 3
Organism
Homo sapiens
Length
261 amino acids
Function
Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).
Similarity
Belongs to the CAVIN family.
Mass
27.701 kDa
Sequence
MRESALERGPVPEAPAGGPVHAVTVVTLLEKLASMLETLRERQGGLARRQGGLAGSVRRIQSGLGALSRSHDTTSNTLAQLLAKAERVSSHANAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEEGEVPASAFQKAPEPLGPADQSELGPEQLEAEVGESSDEEPVESRAQRLRRTGLQKVQSLRRALSGRKGPAAPPPTPVKPPRLGPGRSAEAQPEAQPALEPTLEPEPPQDTEEDPGRPGAAEEALLQMESVA

Gene
CAVIN3
Protein
Caveolae-associated protein 3
Organism
Homo sapiens
Length
261 amino acids
Function
Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).
Similarity
Belongs to the CAVIN family.
Mass
27.701 kDa
Sequence
MRESALERGPVPEAPAGGPVHAVTVVTLLEKLASMLETLRERQGGLARRQGGLAGSVRRIQSGLGALSRSHDTTSNTLAQLLAKAERVSSHANAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEEGEVPASAFQKAPEPLGPADQSELGPEQLEAEVGESSDEEPVESRAQRLRRTGLQKVQSLRRALSGRKGPAAPPPTPVKPPRLGPGRSAEAQPEAQPALEPTLEPEPPQDTEEDPGRPGAAEEALLQMESVA

Gene
CAVIN3
Protein
Caveolae-associated protein 3
Organism
Bos taurus
Length
260 amino acids
Function
Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2.
Similarity
Belongs to the CAVIN family.
Mass
27.487 kDa
Sequence
MGESALESGPVPGAPAGGPVHAVTVVTLLEKLATMLETLRERQGGLAQRQGGLAGSVRRIQSNLGALSRSHDTTSNTLAQLLAKAERVGSHADAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEEAEIPAKAFQKAPEPLGPVELGPQLPEAEAEESSDEEEPVESRARRLRRTGLEKVQSLRRALSGRKGHAAPTPTPVKPPRLGPGRSAEGQWEAQPALESKLEPEPPQDTEEDPGRPGAAEAAAVLQVESAA

Gene
Cavin3
Protein
Caveolae-associated protein 3
Organism
Mus musculus
Length
260 amino acids
Function
Regulates the traffic and/or budding of caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells (PubMed: 28285351, PubMed:23652019). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface (PubMed:25588833). Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (PubMed:23079727).
Similarity
Belongs to the CAVIN family.
Mass
27.853 kDa
Sequence
MGESALEPGPVPETPAGGPVHAVTVVTLLEKLATMLEALRERQGGLAERQGGLAGSVRRIQSGLGALSRSHDTTSNTLTQLLAKAERVGSHADAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEETEIPARAFQKVPELLGPEDQLVLGPDQPEDEVGESSEEEPVESRAQRLRRTGLQKVQSLKRALSSRKAAQPTPVKPPRVGPVRSSEGPSEGQPAAQPEMESELETALEPEPPQPTKEDPEKPVLQIESAA

Gene
CAVIN3
Protein
Caveolae-associated protein 3
Organism
Bos taurus
Length
260 amino acids
Function
Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2.
Similarity
Belongs to the CAVIN family.
Mass
27.487 kDa
Sequence
MGESALESGPVPGAPAGGPVHAVTVVTLLEKLATMLETLRERQGGLAQRQGGLAGSVRRIQSNLGALSRSHDTTSNTLAQLLAKAERVGSHADAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEEAEIPAKAFQKAPEPLGPVELGPQLPEAEAEESSDEEEPVESRARRLRRTGLEKVQSLRRALSGRKGHAAPTPTPVKPPRLGPGRSAEGQWEAQPALESKLEPEPPQDTEEDPGRPGAAEAAAVLQVESAA

Gene
Cavin3
Protein
Caveolae-associated protein 3
Organism
Mus musculus
Length
260 amino acids
Function
Regulates the traffic and/or budding of caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells (PubMed: 28285351, PubMed:23652019). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface (PubMed:25588833). Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (PubMed:23079727).
Similarity
Belongs to the CAVIN family.
Mass
27.853 kDa
Sequence
MGESALEPGPVPETPAGGPVHAVTVVTLLEKLATMLEALRERQGGLAERQGGLAGSVRRIQSGLGALSRSHDTTSNTLTQLLAKAERVGSHADAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEETEIPARAFQKVPELLGPEDQLVLGPDQPEDEVGESSEEEPVESRAQRLRRTGLQKVQSLKRALSSRKAAQPTPVKPPRVGPVRSSEGPSEGQPAAQPEMESELETALEPEPPQPTKEDPEKPVLQIESAA