Protein
Caveolae-associated protein 3
Organism
Rattus norvegicus
Function
Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). Seems to have an immune potentiation function, especially in the glioma (PubMed:15197346).
Similarity
Belongs to the CAVIN family.
Sequence
MGESALEPGPVPGAPAGGPVHAVTVVTLLEKLATMLEALRERQGGLAERQGGLAGSVRRIQSGLGALSRSHDTTSNTLAQLLAKAERVGSHADAAQERAVHRAAQVQRLEANHGLLVARGKLHVLLFKEETEIPARAFQKAPELLGPEDQLVLGPEQPEDEVGESSDEEPVESRAQRLRRTGLQKVQSLKRAFSSRKGSEAAQPTPVKPPRLGPVRNSEGPAEGQPAAQPAMEPVLPSALEPEPPQPTKEDPERPVLQIESAA