CALR3

Gene

CALR3

Protein

Calreticulin-3

Organism

Bos taurus

Length

384 amino acids

Function

During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity).

Similarity

Belongs to the calreticulin family.

Mass

44.512 kDa

Sequence

MAAARVPLWAICVRRVALATVYFQEEFLDGERWRNRWVHSTNDSQFGHFRLSSGNFYGHKEKDKGLQTTQNSRFYAISARFKPFSNKGKTLIIQYTVKHEQKMDCGGGYIKLFPADVDQKNLNGKSQYYIMFGPDICGFDIKTVHVILHFKNQYHANKKSIRCKVDSFTHLYTLVLRPDLTYEVKIDGQSIESGSIEYDWQLTSLKKMEKASAEAEGWDQAAKDKSQDWEKHFLDASASKPSDWKGELDGDWQAAMLQKPPYQDGLKPEGIDKDVWLHQKMKNSYLTEYDLSEFENIGAVGLELWQVRSGTIFDNFLITDDEEYAENFGKATWGETKGPEKEMDAIQAKEEVKKAQEEDEDDMLMGRFRGRENSFKGFHRRNEF

Protein

Calreticulin-3: CALR3

Gene

CALR3

Protein

Calreticulin-3

Organism

Homo sapiens

Length

384 amino acids

Function

During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.

Similarity

Belongs to the calreticulin family.

Mass

44.996 kDa

Sequence

MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHKEKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQKNLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDLSYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQSDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAIGLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEEEELLSGKINRHEHYFNQFHRRNEL

Protein

Calreticulin-3: CALR3

Gene

Calr3

Protein

Calreticulin-3

Organism

Mus musculus

Length

380 amino acids

Function

CALR3 capacity for calcium-binding may be absent or much lower than that of CALR (By similarity). During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility.

Similarity

Belongs to the calreticulin family.

Mass

44.232 kDa

Sequence

MVSARALLWAICVLRVALATVYFQEEFLDGERWRNRWVQSTNDSQFGHFRVSSGKFYGHKEKDKGLQTTQNSRFYAISASFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPSDLDQKKMNGKSQYYIMFGPDICGFDIKKVHVILYFKNQYHENKKPIRCKVDGFTHLYTLILRPDLSYEVKVDGQSIESGSIEYDWNLTSLRKTEKTSLDSRDWDQVEGSKVQDWEKHFLDAGASKPSDWNSELDGDWLQKPPYEDGLKAEGIDKDVWLHQKMRPAGYLTQYDLSEFENIGAIGLELWQVRSGTIFDNFLITDDEEYAEKFGKATWGETKGPEKEMDAIQAKEEVKKAREEDEEDLLMGKFHRHNHFSRFHRQGEL

Protein

Calreticulin-3: Calr3