Protein
Lipoyl synthase, mitochondrial
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Similarity
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Sequence
MRLTTVQRRFLVSTKAKVSGASISSTANTGSASAGAPNGQTRRRRRITEFKDALNLGPSFEDFVSGRAAGFTVVDPLEQMRQDREEYKKLPKWLKVPIPKGVNYHKLKKDVKELKLSTVCEEARCPNIGECWGGKDKSKATATIMLLGDTCTRGCRFCSVKTNRNPAKPDPTEPENTAEAISRWGLGYVVLTTVDRDDLPDGGAHHLAETVIKIKQKAPKTLVEALTGDFLGNLEMVDVMAKSGLDVYAHNLETVEALTPHVRDRRAGYRQSLNVLKRAKETVPSLITKTSVMLGLGETDDQIIQTMQDLRAINCDVITFGQYMRPTKRHMKVVEYVRPEKFDYWKDKAKEMGFLYCASGPLVRSSYKAGEAFIENVLNKRKQDNKRI