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CAF20

Gene
CAF20
Protein
Cap-associated protein CAF20
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
219 amino acids
Function
Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).
Similarity
Belongs to the CAF20 family.
Mass
24.081 kDa
Sequence
MAKYTEEQLFAIKEETSYVPQPQILSAFNELIEQVKEHAHQQQLQYQQQQQQQQGFSGIGSGVSGPGAQKWRNGDTYIDEHGHERSYHHMNRRRPSRSNNGEKKPFFNKKKTEVVVDEDGWETFTPVQHAHRGSIGEDGSEEKSKFRDSVSGSSGSGAGAGAGAGAASGSAGGVRARPNNKNLGSSKQVDPRQIASTKQTRTFNAFEALEGNDDEDDDE

Gene
CAF20
Protein
Cap-associated protein CAF20
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
178 amino acids
Function
Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).
Similarity
Belongs to the CAF20 family.
Mass
20.057 kDa
Sequence
MVKYTEDRLLELKEETYIPQPQILEAFNQMIESVKEHAAAEAEKHKAIKWNNGDTYIDEHGNERPYHHMNRRRASRTANKPSLRKKSVENVDEDGWATLSKPKRSFGADEGLEERAKFRESVREGTVGGSGTVKAKPNNKNLGSSKAVDPRDAIADKHTTTFNAFEALGDGDDDDDDE

Gene
CAF20
Protein
Cap-associated protein CAF20
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
176 amino acids
Function
Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).
Similarity
Belongs to the CAF20 family.
Mass
20 kDa
Sequence
MAKYTEEQLLELKSEAHTPKPEILDAFNKLIEEVKESIEQHQQHQRKWHNGDTYIDEHGHERSYHHINRRRQSKGASGVPRPNLRKKSEPVVDEDGWATLSKPKKGSFAEGDAIEERIKFRETNNSGAGIKARPNNKNLGSSKAVDPREIASDKQTKAFNAFAALGDEDDDDEDDE

Gene
CAF20
Protein
Cap-associated protein CAF20
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
173 amino acids
Function
Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).
Similarity
Belongs to the CAF20 family.
Mass
19.539 kDa
Sequence
MVKYTEDELLEFQEIAYNPQPQVLDAFNQMVDEVREHANAEIERQKHLKWSNGDTYIDENGNERPYHHLNRRRGSRSGAKPNLKRKGAESVTVDDDGWATLAKPKKSFGAEEAGEERTKFRDSLKDGSVKARPNNKNLGSSKAVDPRDAIADKNTISFNAFEALGDDSDDDDE

Gene
CAF20
Protein
Cap-associated protein CAF20
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
171 amino acids
Function
Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).
Similarity
Belongs to the CAF20 family.
Mass
19.47 kDa
Sequence
MAKYTEEQLYEIKEEAYTPQPDVLDAFNKMVDHVKEHAAAEFEKHKNLKWSNGDTYIDENGNERPYHHMNKRRGSRSGNKPNLRKKSTDGIKVDDDGWATLTKPKKSFGAEDGVEERNKFRESVKDIKVKPNNKNLGSSKAVDPRDAIAEKHTNTFNAFEALGDGDDSDDE

Gene
CAF20
Protein
Cap-associated protein CAF20
Organism
Saccharomyces cerevisiae (strain YJM789)
Length
161 amino acids
Function
Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1/TIF4631 and EAP1 for binding to eIF4E/TIF45 and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA. Binding affinity for eIF4E/TIF45 is 10-fold less than that of eIF4G1/TIF4631. Required for induction of pseudohyphal growth in response to nitrogen limitation, probably by regulating STE12 translation (By similarity).
Similarity
Belongs to the CAF20 family.
Mass
18.209 kDa
Sequence
MIKYTIDELFQLKPSVTLEVNFDAVEFRAIIEKVKQLQHLKEEEFNSHHVGHFGRRRSSHHHGRPKIKHNKPKVTTDSDGWCTFEAKKKGSGEDDEEETETTPTSTVPVATIAQETLKVKPNNKNISSNRPADTRDIVADKPILGFNAFAALESEDEDDEA

Gene
CAF20
Protein
Cap-associated protein CAF20
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
161 amino acids
Function
Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1/TIF4631 and EAP1 for binding to eIF4E/TIF45 and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA. Binding affinity for eIF4E/TIF45 is 10-fold less than that of eIF4G1/TIF4631. Required for induction of pseudohyphal growth in response to nitrogen limitation, probably by regulating STE12 translation.
Similarity
Belongs to the CAF20 family.
Mass
18.223 kDa
Sequence
MIKYTIDELFQLKPSLTLEVNFDAVEFRAIIEKVKQLQHLKEEEFNSHHVGHFGRRRSSHHHGRPKIKHNKPKVTTDSDGWCTFEAKKKGSGEDDEEETETTPTSTVPVATIAQETLKVKPNNKNISSNRPADTRDIVADKPILGFNAFAALESEDEDDEA

Gene
CAF20
Protein
Cap-associated protein CAF20
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
154 amino acids
Function
Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).
Similarity
Belongs to the CAF20 family.
Mass
17.274 kDa
Sequence
MIKYSIDELIQLKPSETLKVSFDHVEFRNIIEKVVELQKLKEEEFHSHHGNRRRSSHHHMKPKIKHNKPKVKTDADGWSTLEPATAGHEEESSSSATPAAAATTKTGAPQETIRVKPNNKNISSSRPADNSDIIADKQTHGFNAFAALEDEEDE

Gene
CAF20
Protein
Cap-associated protein CAF20
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
Length
152 amino acids
Function
Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).
Similarity
Belongs to the CAF20 family.
Mass
17.304 kDa
Sequence
MVRYTVDELFHLKPTESLPVQFDAEEFKAIIEKVKQIQALKEEEFNAHGGHFNRRRSSHHHHGRPKVKHTKPKVTTDSDGWSTFEAANKKVNEDEESENVSVAVVPETLKVKPNNKNISSSRPADNKDIIADKQTHSFNAFAALESDEEEET

Gene
CAF20
Protein
Cap-associated protein CAF20
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
147 amino acids
Function
Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).
Similarity
Belongs to the CAF20 family.
Mass
16.433 kDa
Sequence
MAKYTEEELLQLKPTYDVAVNFDVDAFKAMIAEVAEHHEIADLFHQKARRRSSHHHGVKPKIKAHKPRITTDDDGWCTSTRKTSVVAVGDDGEPSPAFVAQETLRVKPNNKNIASSRPADTRDIVADKPTMSFNAFAALESDDEDQF

Gene
CAF20
Protein
Cap-associated protein CAF20
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
147 amino acids
Function
Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).
Similarity
Belongs to the CAF20 family.
Mass
16.998 kDa
Sequence
MIRYTEEELLQLRPTEPVKPNFDVDEFNAIIEKVKEIQEAHEEEFSHFRRRSSHHHAKPKFKHLKPKITTDEEGWSTLETAPAVRRKSVAEEEEPTIVIAQETLKVKPNKHISSSRPADARDIVADKPSKAFNAFAALESDEEEEQE