CABIN1

Calcineurin-binding protein cabin-1

2220 amino acids

May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.

246.352 kDa

MIRIAALNASSTIEDDHEGSFKSHKTQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEASLLREAVSSGDEKEGLKHPGLILKYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRIPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLKCDMSIHDVSVSAAETQAIVDEALGLRKKRQALIVREKEPDLKLVQPIPFFTWKCLGESLLAMYNHLTTCEPPRPSLGKRIDLSDYQDPSQPLESSMVVTPVNVIQPSTVSTNPAVAVAEPVVSYTSVATTSFPLHSPGLLETGAPVGDISGGDKSKKGVKRKKISEESGETAKRRSARVRNTKCKKEEKVDFQELLMKFLPSRLRKLDPEEEDDSFNNYEVQSEAKLESFPSIGPQRLSFDSATFMESEKQDVHEFLLENLTNGGILELMMRYLKAMGHKFLVRWPPGLAEVVLSVYHSWRRHSTSLPNPLLRDCSNKHIKDMMLMSLSCMELQLDQWLLTKGRSSAVSPRNCPAGMVNGRFGPDFPGTHCLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARFLALQGDMEQALENYDICTEMLQSSTAIQVEAGAERRDIVIRLPNLHNDSVVSLEEIDKNLKSLERCQSLEEIQRLYEAGDYKAVVHLLRPTLCTSGFDRAKHLEFMTSIPERPAQLLLLQDSLLRLKDYRQCFECSDVALNEAVQQMVNSGEAAAKEEWVATVTQLLMGIEQALSADSSGSILKVSSSTTGLVRLTNNLIQVIDCSMAVQEEAKEPHVSSVLPWIILHRIIWQEEDTFHSLCHQQQLQNPAEEGMSETPMLPSSLMLLNTAHEYLGRRSWCCNSDGALLRFYVRVLQKELAASTSEDTHPYKEELETALEQCFYCLYSFPSKKSKARYLEEHSAQQVDLIWEDALFMFEYFKPKTLPEFDSYKTSTVSADLANLLKRIATIVPRTERPALSLDKVSAYIEGTSTEVPCLPEGADPSPPVVNELYYLLADYHFKNKEQSKAIKFYMHDICICPNRFDSWAGMALARASRIQDKLNSNELKSDGPIWKHATPVLNCFRRALEIDSSNLSLWIEYGTMSYALHSFASRQLKQWRGELPPELVQQMEGRRDSMLETAKHCFTSAARCEGDGDEEEWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAMEALEVYFRLHASILKLLGKPDSGVGAEVLVNFMKEAAEGPFARGEEKNTPKASEKEKACLVDEDSHSSAGTLPGPGASLPSSSGPGLTSPPYTATPIDHDYVKCKKPHQQATPDDRSQDSTAVALSDSSSTQDFFNEPTSLLEGSRKSYTEKRLPILSSQAGATGKDLQGATEERGKNEESLESTEGFRAAEQGVQKPAAETPASACIPGKPSASTPTLWDGKKRGDLPGEPVAFPQGLPAGAEEQRQFLTEQCIASFRLCLSRFPQHYKSLYRLAFLYTYSKTHRNLQWARDVLLGSSIPWQQLQHMPAQGLFCERNKTNFFNGIWRIPVDEIDRPGSFAWHMNRSIVLLLKVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTLSELAEGSERPGPKVCGLPGARMTTDVSHKASPEDGQEGLPQPKKPPLADGSGPGPEPGGKVGLLNHRPVAMDAGDSADQSGERKDKESPRAGPTEPMDTSEATVCHSDLERTPPLLPGRPARDRGPESRPTELSLEELSISARQQPTPLTPAQPAPAPAPATTTGTRAGGHPEEPLSRLSRKRKLLEDTESGKTLLLDAYRVWQQGQKGVAYDLGRVERIMSETYMLIKQVDEEAALEQAVKFCQVHLGAAAQRQASGDTPTTPKHPKDSRENFFPVTVVPTAPDPVPADSVQRPSDAHTKPRPALAAATTIITCPPSASASTLDQSKDPGPPRPHRPEATPSMASLGPEGEELARVAEGTSFPPQEPRHSPQVKMAPTSSPAEPHCWPAEAALGTGAEPTCSQEGKLRPEPRRDGEAQEAASETQPLSSPPTAASSKAPSSGSAQPPEGHPGKPEPSRAKSRPLPNMPKLVIPSAATKFPPEITVTPPTPTLLSPKGSISEETKQKLKSAILSAQSAANVRKESLCQPALEVLETSSQESSLESETDEDDDYMDI

Cabin1

Calcineurin-binding protein cabin-1

2182 amino acids

May be required for replication-independent chromatin assembly (By similarity). May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin.

242.813 kDa

MIRIAALNASSTIEDDHEGSFKSHKIQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEARLLREAVSSGDEKEGLKHPGLILKYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLKCDMSVHEVSVNAAETQAIVDEALGLRKKRQALIVREKEPDLKLVQPIPFFTWKCLGESLLAMYNHLTTCEPPRPSLGKRIDLSDYQDPSQLLAPSIVVTPVSVVQPSPVCTNPTVAVAEPVLSYTSVTTTSFPLHSPGLLDTGTPMGDVSGGDKSKKGVKRKKTLEESGETAKRRSARVRNTKCKKEEKVDFQGLLVKFLPSRLRKLDPEEEDDPFNNYEVQSEAKLESFSNVGPHRLSFDSATFMESEKQDVHAFLMENLTNGGVLELMMRYLKSMGHKFLLKWPPGLAEVVLSVYHSWRRHSTSLPNPLLRDCSNKHIKDMMLMSLSCMELQLDQWLLTKGRSSTVSPRNCPAGVVTGRFGPDFPGTHCLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARFLALQGDMEQALENYDICTEILQSSTALQAQAGAEQRDIVIRLPNLHNDSIVSLEEIDKNLKSLERCQSLEEIQRLFEAGDYKAVVQLLRPTLCTSGFDRAKHLEFMTSIPERPAQLLLLQDSLLRLEEHRQCFECSDVALNEAVQQMLNSSDSAAKEEWAATVTQLLLGMEQALSSDSRGSILKESSSPTGLVRLTNNLIQVIDCSMAVQEEPKEPYVSSVLPWIILHRIIWQEEDTFRSLCHQQQLQNPTEEGISEMPMLPSSLMLLNTAHEYLGRRSWCCNSDGALLRFYVHVLQKELAASASEDTHPYKEELETALEQCFYCLYSFPSKKSKARYLEEHSAQQVDLTWEDALFMFEYFKPKTLPEFDSYKTSTVSADLANLLKRIATIVPRTEKPALSMDKVSAYIEGTSAEVPCLPDGADPAPPVLNELYYLLADYHFKNKEQSKAIKFYMHDICICPNRFDSWAGMALARASRIQDKLNSNELKSDGPIWRHATPVLNCFRRALEIDSSNLSLWIEYGTMSYALHSFASRQLKQWRAELPPEVVQQMEDRRDSMLETARHCFTSAAHCEGDGDEEEWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAMEALEVYFRLHASILKLLGKPDSGVSAEVLVSFMKEAAEGPFARGEEKNTPKASEKEKACLVDEDSHSSAGTLPGPGASLPSSSGPGLTSPPYTATPIDHDYVKCKKPRQQATPDDRSQDSTAVALSDSSSTQDFFNEPTSLLDGSRKLLPEKRISGLSAQAGPSGKDLPGPTEERGKTEESLESTEAFRVVEPSVQKPVADSSASAYIPSKPAVSTPPPWDGKKRSDPLGEPVAFPQGLPAGAEEQRQFLTEQCIASFCLCLSRFPQHYKSLYRLAFLYTYSKTHRNLQWARDVLLGSSIPWQQLQHMPAQGLFCERNKTNFFNGIWRIPVDEIDRPGSFAWHMNRSIVLLLKVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTLSELAEGLEHPGSKACGLSGARMTTDVSHKASPEDGQESLPHPKKLPLADGSGPGPEPGGKVGPLHQLPVATDTRDNTEQGGEPKDKERPPVGPTEPMDTGETAARHPDLEPTPRLLPGRPPRDRGPESRSAELSLEELSISTRQQPAPLVPSPVTPTTAAPTTMGARAAGHPEEAPPRPNRKRKLLQDTESGKTLLLDAYRVWQQGQKAMAYDLSRIEKIMSETYMLIKQVDEETALEQAVKFCQVHLGAAAQRQASGDAPTTPKHPKDSRENFFPATVAPSAPDTTAPDALQRPSDSHLKPGLAAAITCPPSASASTPDPGIPQPHRPEAVPSRAPLSPDGEEVSGVTEGPSFLSQEPRHSHQMKMAATGPLAEQHCWPVEAACQTGAEPTFSQATSTKVPSSGSTQTPESHQGKTESSRAKSRLLPNMPKLVIPSATTKFPPEITVTPPTPTLLSPKGSISEETKQKLKSAILSAQSAANVRKESLCQPALEVLETSSQESSLESETDEDDDFMDV

CABIN1

Calcineurin-binding protein 1

1863 amino acids

May be required for replication-independent chromatin assembly.

210.741 kDa

MFSIAAINDTESTEKWEPLAPSKEAQEFHLSQTYHDGLLKLQAKDYDKARELLESILKDPIITNSKVETIANDNHLHHLRFLALKNLATVFLELGSSHYENALNCYLQAIDLDAKDSVLWNHLGTLSCSMGLLSISRWAFEQGLLCSPNNWNCMEKLLEVLIAVGDEVSCLSVANLILRHWPSHSRALHVKHCIEDTDSAPFAPKGIDKLEPQHVRLKFLGKRKVSDMNQDMDATSKKLRKRVQFKLPEASWVALLNILIGIVHPSRETVGISADIPITIELSLSTEAVMQGMKKKDHCVDSDSSNVSVKDCNIERESGGSVKEKEPVFSEEHPQERRSTRLERLRNQKPEKEGLEFDNSKDPSSDILQYLEKFVLKRGFDRESAGSFCNEESDPISEHAVVSNFVKENLENYGAYHMGHLLLEYIANKCEHVLSRETALKILELEKLTRHWGRDRKPECSLFLAELYHDFDSKRSDIPDAPSCMVEVTYHLSKIIESVSLDYAIDSTPSSRGKMFSDSSFKSFQGDEAAKEVLDYDTRSFWARYFWLSARLSILEDNKAKALEEYLRCLSLLGREGIGEAPVLIQRPHCRRVRELTINRIIHEINLLKIDFLLENNIPEMMEKEFYSECVNLLAPLLFPDKDILPAYAVKTEEGISSVELSALEVLIKACQKSKPIDVEVYMNCHRRKLQVLLDSTGTGESVVTPKTSSKNSSESWDHLVAEEVKAILLCISQVKNSLDQSGNSDDMVAPRDCVAGIQALLLRVMSNIVRHFFSKRYSDSQNADGIEEEKKSCFLDAAIGFCKLQHLDATISTKYQVELIIRLHDLLAEYGLCCAGKNCAGEEGAFLRFAIKHLLAVDMKVKSSINSPDGLGHDMGLPDKLCRNEVKSFLEEVHVEKNENNKTESKKDGSEEQVGYREKEQSEQQSKQIPEHTEEVAEEEKDELELLINNALDQCFFCLYGLNLRVDGSYEDELAVHKNTSRGDYQTKEQCVDVFQYILPYAKASSRTGLVKLRRVLRAIKKHFSQPPDDLLIGNVIDKFLDDPELCEDKLSYEAGSEGFLETITKCLIPSRTLSEYKISLLHSSDPYLDVYRNLYFLLAQSEEVSASDKWPGFVLTKEGEEFEQQNTNLFKYDLLYNPLRFESWEKLGNIYDEEVDLLLNDGSKHINVVGWRKNSALSQRVETSRRRSRRCLLMSLALANSPDQQSEIHELLALVYYDSLQSVVPFYDQRSVLPSKDATWTRFCENSMKHFNKAFSHRQDWSHAFYMGKLSEKLGHSYEISLSYYKQAMTLNPSAVDPVYRMHASRLKLLNACGKQNLEALKVLASYCFDESIKDTAMTIIGTTTFGSSRTLEEAQDGNLEACYAKSGEGSIQMEGVWHMLYNDSLSALGICVEGDLKHFHKARYMLAQGLYRRGGSSDLQRAKEELSFCFKSSRSSFTINMWEIDGMVKKGRRKTPGLAGNKKALEVNLPESSRKFITCIRKYLLFYLRLLEETEDVNTLERAFNSLRSDKRFSLCVEDLVPVAIGRYVKALVSSMSRVESAGAIINPDSQLEKIFSLFIEQGSIWPDICNFPETRGPETSESSLYRYLHQYIVSLELDNKVETLETINEKIRKRFKNPKLSNSFSAKVGRHASLAWCRALIISLALITPLQPVSSEESQAITPSFGLLENRRVLCVDLQSEFWSSSFEDPLESQMLEAKWRPVLSKIKNVLIFNKVVEGNLEIANSLLKSCYNFFRETASVTLPSDINLYFALPRLAPAGELLPGNEGVEVIDVSIPRKLLLWAYTLFHGHCGSISQVVKYMEENTKPKMKRGASTSSVVPSVQSGGTSEPEPAPKVVQVIIPDSLGGDSCGSTPAAPL