Protein
NAD-dependent protein deacylase
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Function
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
Similarity
Belongs to the sirtuin family. Class III subfamily.
Sequence
MNKQLKEFQEYLPKCRKIIALVGAGLSASSGLPTFRGSQGLWKNFNMIDLATPDAFYIDPGLVWQFYSWRRYGALRAKPNKGHYALSKLSHKFNSDEYITITQNVDGLSSRSGHNLDSLYEIHGSLFDLKCTSFMCNYVDHNNFKQPLTKALEDTEFEYSNLSTRKRTFGDSDGNDGVDISLSPQFNPVKTISEKDLPSCPVCHDLLRPGVVWFGESLPLNLITEIDSFVESDPSVDLILVIGTSGTVYPANSYVERVRLKGGKVAIFNTDIEDNILNGKVEDTWGFKGDAAELLPIALKPLIGDI