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C5AR1

Gene
C5AR1
Protein
C5a anaphylatoxin chemotactic receptor 1
Organism
Canis lupus familiaris
Length
352 amino acids
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1472004). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
39.213 kDa
Sequence
MASMNFSPPEYPDYGTATLDPNIFVDESLNTPKLSVPDMIALVIFVMVFLVGVPGNFLVVWVTGFEVRRTINAIWFLNLAVADLLSCLALPILFSSIVQQGYWPFGNAACRILPSLILLNMYASILLLTTISADRFVLVFNPIWCQNYRGPQLAWAACSVAWAVALLLTVPSFIFRGVHTEYFPFWMTCGVDYSGVGVLVERGVAILRLLMGFLGPLVILSICYTFLLIRTWSRKATRSTKTLKVVVAVVVSFFVLWLPYQVTGMMMALFYKHSESFRRVSRLDSLCVAVAYINCCINPIIYVLAAQGFHSRFLKSLPARLRQVLAEESVGRDSKSITLSTVDTPAQKSQGV

Gene
C5ar1
Protein
C5a anaphylatoxin chemotactic receptor 1
Organism
Rattus norvegicus
Length
352 amino acids
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:9464523). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
39.417 kDa
Sequence
MDPISNDSSEITYDYSDGTPNPDMPADGVYIPKMEPGDIAALIIYLAVFLVGVTGNALVVWVTAFEAKRTVNAIWFLNLAVADLLSCLALPILFTSIVKHNHWPFGDQACIVLPSLILLNMYSSILLLATISADRFLLVFKPIWCQKFRRPGLAWMACGVTWVLALLLTIPSFVFRRIHKDPYSDSILCNIDYSKGPFFIEKAIAILRLMVGFVLPLLTLNICYTFLLIRTWSRKATRSTKTLKVVMAVVTCFFVFWLPYQVTGVILAWLPRSSSTFQSVERLNSLCVSLAYINCCVNPIIYVMAGQGFHGRLRRSLPSIIRNVLSEDSLGRDSKSFTRSTMDTSTQKSQAV

Gene
C5ar1
Protein
C5a anaphylatoxin chemotactic receptor 1
Organism
Mus musculus
Length
351 amino acids
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
39.023 kDa
Sequence
MDPIDNSSFEINYDHYGTMDPNIPADGIHLPKRQPGDVAALIIYSVVFLVGVPGNALVVWVTAFEARRAVNAIWFLNLAVADLLSCLALPVLFTTVLNHNYWYFDATACIVLPSLILLNMYASILLLATISADRFLLVFKPIWCQKVRGTGLAWMACGVAWVLALLLTIPSFVYREAYKDFYSEHTVCGINYGGGSFPKEKAVAILRLMVGFVLPLLTLNICYTFLLLRTWSRKATRSTKTLKVVMAVVICFFIFWLPYQVTGVMIAWLPPSSPTLKRVEKLNSLCVSLAYINCCVNPIIYVMAGQGFHGRLLRSLPSIIRNALSEDSVGRDSKTFTPSTTDTSTRKSQAV

Gene
C5AR1
Protein
C5a anaphylatoxin chemotactic receptor 1
Organism
Gorilla gorilla gorilla
Length
350 amino acids
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
39.376 kDa
Sequence
MDSFNYTTPDYGHYDDKDTLDPNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEVKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACRILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKQRERAVAVVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAEKTQAV

Gene
C5AR1
Protein
C5a anaphylatoxin chemotactic receptor 1
Organism
Homo sapiens
Length
350 amino acids
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
39.336 kDa
Sequence
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV

Gene
c5ar1
Protein
C5a anaphylatoxin chemotactic receptor 1
Organism
Oncorhynchus mykiss
Length
350 amino acids
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
39.323 kDa
Sequence
MDDMCSILTEEELSLYNITDCEFVKPGGLGPVLGPRHLSALVFYGLVFLLGVPGNALVVWVTGFRMPRSVTSLWFLNLALADLLCCLSLPLLMVPLAMDQHWPFGPVACKLLKGLLYLIMFCSVLLLVLISLDRFLLVSWPVWCQNWRRPRKAGWVCVGVWLLALLGSIPQFVYVKEVQLSTSKSECLGLYTVASAWANTTARFLVGFVLPFITIVTCHWVVYSRARRGSGVGPGRVSEARSRRTLRVIVAVSLSFFLCWFPLHILDFLVLSTPRHSSHSANIQLAHTLALCLAYCNSCLNPLLYVCLGRGFKQNINRSLRNMFNFATEESVTRQSMFKSTSERTQEMNM

Gene
C5AR1
Protein
C5a anaphylatoxin chemotactic receptor 1
Organism
Pan troglodytes
Length
350 amino acids
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
39.339 kDa
Sequence
MDSFDYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLMICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFRLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLQKSLPSLLRNVLTEESVVRESKSFARSTVDTMADKTQAV

Gene
C5AR1
Protein
C5a anaphylatoxin chemotactic receptor 1
Organism
Oryctolagus cuniculus
Length
350 amino acids
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10510441). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
38.586 kDa
Fragment
single
Sequence
APMENSTYDYTNYDSLGTLDPSTPVDNTVRRLRPTTIVALVIYMAVFLVGVPGNALVVWVTALEAKRTVNAIWFLNLAVADLLSCLALPILFVSIIQEGHWPFGRAACSVLPSLILLNMYASILLLATISADRFLLVFNPIWCQNTRGAGLAWLACCVAWGLALLLTIPSFLYRKVLQDDYPPKTTCGVDYGHEGVRAERAVAIVRLVVGFLLPLFTLSVCYTFLLLRTWSRNGTRSTKTLKVVVAVVVSFFIFWLPYQVMGMILALLHPSSATFRWAIRLDPLCIALAYVNCCINPIIYVVAGKGFQGQLRKSLPSLLRNVLAEESVIQGSKSFSRSTVDTVADKCQAV

Gene
c5ar1
Protein
C5a anaphylatoxin chemotactic receptor 1
Organism
Danio rerio
Length
346 amino acids
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
39.115 kDa
Sequence
MDDNNSDWTSYDFGNDTIPSPNEISLSHIGTRHWITLVCYGIVFLLGVPGNALVVWVTGFRMPNSVNAQWFLNLAIADLLCCLSLPILMVPLAQDQHWPFGALACKLFSGIFYMMMYCSVLLLVVISLDRFLLVTKPVWCQNNRQPRQARILCFIIWILGLLGSSPYFAHMEIQHHSETKTVCTGSYSSLGHAWAITIIRSFLFFLLPFLIICISHWKVYHMTSSGRRQRDKSSRTLRVILALVLGFFLCWTPLHIVDLLILVSDQPSERFEVNLNLAHVLTLCLAYINSCLNPLLYVCLGRGFKENLISSLRSVLHFASEAPTHGPSMTTNSKSTTDGVFREKPV

Gene
C5AR1
Protein
C5a anaphylatoxin chemotactic receptor 1
Organism
Cavia porcellus
Length
345 amino acids
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:9576615). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
38.592 kDa
Sequence
MMVTVSYDYDYNSTFLPDGFVDNYVERLSFGDLVAVVIMVVVFLVGVPGNALVVWVTACEARRHINAIWFLNLAAADLLSCLALPILLVSTVHLNHWYFGDTACKVLPSLILLNMYTSILLLATISADRLLLVLSPIWCQRFRGGCLAWTACGLAWVLALLLSSPSFLYRRTHNEHFSFKVYCVTDYGRDISKERAVALVRLLVGFIVPLITLTACYTFLLLRTWSRKATRSAKTVKVVVAVVSSFFVFWLPYQVTGILLAWHSPNSATYRNTKALDAVCVAFAYINCCINPIIYVVAGHGFQGRLLKSLPSVLRNVLTEESLDKRHQSFARSTVDTMPQKSESV

Gene
C5AR1
Protein
C5a anaphylatoxin chemotactic receptor 1
Organism
Macaca mulatta
Length
340 amino acids
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
38.274 kDa
Fragment
single
Sequence
TPDYGHYDDKDTLDANTPVDKTSNTLRVPDILALVIFAVVFLVGVLRNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACRILPSLILLNMYASILLLATISADRFLLVFNPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDHGHDKRRERAVAIARLVLGFVWPLLTLTMCYTFLLLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGMMMSFLEPSSPTFLLLKKLDSLCISFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESMVRESKSFTRSTVDTMAQKT

Gene
C5AR1
Protein
C5a anaphylatoxin chemotactic receptor 1
Organism
Pongo pygmaeus
Length
340 amino acids
Function
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
38.241 kDa
Fragment
single
Sequence
TPDYEHYDDNDMLDANTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACRILPSLILLNMYASILLLATISADRFLLVFNPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDHGHDKRRERAVAIVRLVLGFVWPLLTLTICYTFLLLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGMMMSFLEPSSPTFLLLKKLDSLCISFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKT