About Products Protein Database Contact

C4BPB

Gene
C4bpb
Protein
C4b-binding protein beta chain
Organism
Rattus norvegicus
Length
258 amino acids
Function
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It interacts also with anticoagulant protein S and with serum amyloid P component.
Mass
28.642 kDa
Sequence
MLCLVVCCLIWLISALDGSCSEPPPVNNSVFVGKETEEQILGIYLCIKGYHLVGKKSLVFDPSKEWNSTLPECLLGHCPDPVLENGKINSSGPVNISGKIMFECNDGYILKGSNWSQCLEDHTWAPPLPICRSRDCEPPETPVHGYFEGETFTSGSVVTYYCEDGYHLVGTQKVQCSDGEWSPSYPTCESIQEPPKSAEQSALEKAILAFQESKDLCNATENFVRQLREGGITMEELKCSLEMKKTKLKSDILLNYHS

Gene
C4BPB
Protein
C4b-binding protein beta chain
Organism
Homo sapiens
Length
252 amino acids
Function
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
Mass
28.357 kDa
Sequence
MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSLELKKAELKAKLL

Gene
C4BPB
Protein
C4b-binding protein beta chain
Organism
Bos taurus
Length
198 amino acids
Function
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with serum amyloid P component.
Mass
22.829 kDa
Sequence
MFFWLMCYLVDVWLISASDVGHCPDPLLVTDEFSSLEPVNVNDTFMFKCNEHCIFKGSNWSQCRENHTRVTHSPVSKSRDCGPPETPTHGYFEGRDFKSGSTITYYCEARYRLVGTQHQQCIDGEWTSAPPICELIQEAPKPAELELEKAFLAFQESKELCKAIKKFTQRLKKSDLTMEKVKYSLERKKAKLKAKMLL