Protein
4-hydroxyproline 2-epimerase
Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)
Function
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity.
Similarity
Belongs to the proline racemase family.
Sequence
MKRIQIIDSHTGGEPTRLVVSGFPSLGDGTMAERRDVLAREHDRYRTACILEPRGSDVLVGALLCDPVAPDAAAGVIFFNNSGYLGMCGHGTIGVVRTLHHMGRIAPGVHRIETPVGTVEATLHDDLSVSVRNVPAYRHAQGVALDVPGYGPVKGDIAWGGNWFFLISDHGQRVAGDNVAALTAYASAVREGLERAGITGANGGEIDHIELFADDPEHDSRSFVLCPGLAYDRSPCGTGTSAKLACLAADGKLAPGAVWRQASVIGSVFHASYERADGGIVPTIRGSAHLSAEATLLIEEDDPFGWGIGS