About Products Protein Database Contact

BRE1

Gene
bre1
Protein
Probable E3 ubiquitin-protein ligase bre1
Organism
Dictyostelium discoideum
Length
1080 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B.
Similarity
Belongs to the BRE1 family.
Mass
126.556 kDa
Sequence
MSMDHQDLKRRDPPADSESQRPSKKISLSSSEASVPIGGPPIDQNLILFQNRAMKVRVEEQKIEINDREQKIKQLNTKIHQYKENISCLCRVWDQLNSGLDLLINRVDFENAMDNLLPKDNITESFEFLSSYITEPVTLDEKYTLDQSLQKKVQKTQSTFSKISKALEKEHTLSKFVFRLLKSKDGIKSNDIEKLLKEDNDKLSKQNQYIQNIYDKVQIQFKQLTDQTTHLADQAAIYQQNNKELKLELEKSQDELTIERKRVIKLQDETLRTPQVKIPSPSLGSNIPGGANNNNNNNNNSNNNNNINNNGNNMGGSGSSSLASSTNGINKQQSNDINGKELTHEELIAELQRQSDSRLLEARKLREEKAILLKELQQIQIDIRVIPEERIQNSMPYQVLRQRYQLVSDELDIHRNQCTKLQNDLAQATIGRRLEREALEAFEAHRRQNIERRVSQLEVESIELKGEKEKLVCLIEQRNPNVPSLQYIQESRLLLDKKDDEIKQLRKEIEQLKLDIEKYKAPKEEIERYKLLVQRDVESKNIEINKLLEKINTITKQNNDLKSNEQQLLQKESELTLSLNILKSNKNNININNLDKDNIEDNSKIKQQQEQQQQQHQKIDNNNKKEEEIKKEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEEQKKDKEMIDIEKSTENIINNNNNNNTNEQKLNEINKNIENGNNENNNNNENTINNENTINNNNNENKDKIIFNLELNESKLKLELSTVKKQLEDITKSKEEYDNEIKEINEKFKAQIKELDITISQNKIQQESQKQELEALVMEIDSMGKAYEQMLEQNTRLTKQLSDKEDTHAHLMAENIKSQQTIRNSKEIQLAIEEKLNRNEEKLKSQGELMQKIEEKSNILQKQLSKVTEDLHSCSFDLEKHKRFVRENNAHSLELKTQLDHLSNLNAELKKKADDSIFALEREIDKAKRLDEEKQLLKKKLEKATSANNNNNNNNNNNNNNNNNNSSSSEEELKLINQRLRCTICNDRQKNYVIAKCFHVFCKECIYSNIDTRKRRCPSCNRAFAETDVHQIYY
Protein
Probable E3 ubiquitin-protein ligase bre1: bre1

Gene
Bre1
Protein
E3 ubiquitin-protein ligase Bre1
Organism
Drosophila melanogaster
Length
1044 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It thereby plays a central role in histone code and gene regulation. Required for the expression of Notch target genes in development by affecting the levels of Su(H) in imaginal disk cells and stimulating the Su(H)-mediated transcription of Notch-specific genes.
Similarity
Belongs to the BRE1 family.
Mass
119.06 kDa
Sequence
MSKRSADDATGSSCLVAAAAAGQPPIKKVHFEPHLIGPVSTLEEMDIKVLEFQNKKLAQRIEQRMRTEAELRHRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFDAETADELENRNENEVTTSFLAQLSTWDKEELDEKLANRVQVSKRAVAKIVQVIDRLMQRNEKITHVLKGDSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHALEETLKQTHIEIMSENHKLQNLNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDLEKIHCRNDKLENHLAEAIEKLKAYHQIYGDPNKSTNSAKTPTTTGSGGATTSVNSQLLEELQKELEEYRELANNRLQELDKLHATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQIKTMLDETRNQLQTSKNQHLRQIEVMESEELIAQKKVRSEMIQMEDVLALIRKEYETLRIEFEQNMAANEQTAPINREMRHLITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADALATLEGNKLQAATGAAGEEIKQENSTGVKEENSNNVSASGQTNQTNSGNDTNVAIKEENHISAEDEADDEASGKDVKDGIKQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGKDVKAVESETVRDLKAQLKKALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQQLKKLQESKREERKKLADEEALRKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFVGSHEEEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLEDQMATATTQIEAMHIVLRKLEEKERSLQATVASIEKELMLRQQAMEMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAERMKKMEMSGTTIDEVMIEEIREYKETLTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYLQ
Protein
E3 ubiquitin-protein ligase Bre1: Bre1

Gene
BRE1
Protein
E3 ubiquitin-protein ligase BRE1
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
820 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
92.867 kDa
Sequence
MNADLKRVRENTLDDSPSPSAKRRLNSNASSPIQPSDDEGMAEWMKIVEVKRKEAIYRQMLEYRRISEHETKRANDLEAQRRVLEASFHAVELCWTQIVAAVRDLAGAENLQLKEEEVLEPLLDPSTPVPELEKALRSRLPTTRQLVTRFVDLVAHNATRPASEADLQARCLKLEAEASALRSNSKLLESEISALKGSRDEAQRDLQRIRKALDRERMEHGKAQEEWKEERTRGGQATPNLRANGSGHSTPNGKVEADKKFYSGAGPSMAGVLQDTSELEQLAASRLKQLEQLRFEQTQLQQEVDRLKILANHPSETALRESPFFQVYLHQLSTSINRAESLQTRFTATESKLDQLRDSNGEFREAVLAEARGQTETLRAQMAKKDSDIARLRGQRDELNSEIMERRAKEVEKCKYTEQIENLANSRQERISFLTSEVRRLKGKLAAAHSSDGYLSFLKESGIDGDYVKDLEAKVVTSQDQINALTSQLERVSSDTAAAKSETEVRTELESAKRLLARYERILGPNPEAAEDVRYLSQQLEKKEKERASLEMKLEEAEAATNALYSEVEGLSKLWEALDQTVKSKVLELRDGEQKITRLATEKAKADNKYFAAMRAKEAVDMEAKAAQRSVEKQLRLLERAQEVETSLRSQITANEKGLTALKNNALDLQNQLATVVAEKTQLELRLQQSQNALVEAQQIMHQRVAEAIAEKEARAKLQDEADGQMKIIKKLKERQDAVAAASQTGMSDHEWAITQERDKLLKLLKCSCCEQNFKQQVIVKCMHTFCKQCLEQRIASRQRKCPACGLAFAKEDIQTLYWQ
Protein
E3 ubiquitin-protein ligase BRE1: BRE1

Gene
BRE1
Protein
E3 ubiquitin-protein ligase BRE1
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
820 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
92.837 kDa
Sequence
MNADLKRVRENTLDDSPSPSAKRRLNSNASSPIQPSDDEGMAEWMKIVEVKRKEAIYRQMLEYRRISEHETKRANDLEAQRRVLEASFHAVELCWTQIVAAVRDLAGAENLQLKEEEVLEPLLDPSTPVPELEKALRSRLPTTRQLVTRFVDLVAHNATRPASEADLQARCLKLEAEASALRSNSKLLESEISALKGSRDEAQRDLQRIRKALDRERMEHGKAQEEWKEERTRGGQATPNLRANGSGHSTPNGKVEADKKFYSGAGPSMAGVLQDTSELEQLAASRLKQLEQLRFEQTQLQQEVDRLKILANHPSEAALRESPFFQVYLHQLSTSINRAESLQTRFTATESKLDQLRDSNGEFREAVLAEARGQTETLRAQMAKKDSDIARLRGQRDELNSEIMERRAKEVEKCKYTEQIENLANSRQERISFLTSEVRRLKGKLAAAHSSDGYLSFLKESGIDGDYVKDLEAKVVTSQDQINALTSQLERVSSDTAAAKSETEVRTELESAKRLLARYERILGPNPEAAEDVRYLSQQLEKKEKERASLEMKLEEAEAATNALYSEVEGLSKLWEALDQTVKSKVLELRDGEQKITRLATEKAKADNKYFAAMRAKEAVDMEAKAAQRSVEKQLRLLERAQEVETSLRSQITANEKGLTALKNNALDLQNQLATVVAEKTQLELRLQQSQNALVEAQQIMHQRVAEAIAEKEARAKLQDEADGQMKIIKKLKERQDAVAAASQTGMSDHEWAITQERDKLLKLLKCSCCEQNFKQQVIVKCMHTFCKQCLEQRIASRQRKCPACGLAFAKEDIQTLYWQ
Protein
E3 ubiquitin-protein ligase BRE1: BRE1

Gene
BRE1
Protein
E3 ubiquitin-protein ligase BRE1
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
817 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
91.239 kDa
Sequence
MLQSMSGADDRKRALTGTVEDGPRKRLHSDEATSKSAATPTNDNEDDEALHPAYAGLEAFRKEAIYRKLLEARRDLQRIERRAGTFQDDLAVSEQRAAVLQRFWNLLLTELAARLAIQDQDVFALSSASDSRSDLTAMEQQLEQQSSAVLRCLSQQGDVNIVELQQKLHDLADEGSRYKQDLFLTQSKLQRAQDALAQTSQKLSKVEHEYVRYQSNLLRATEGKPTIPAGTIVSASEPAPATEQTADTAVKKETATLAPTDGAPHTSETLQKAVDELESARQDVELTRRESDSRYAEIQTLNEEVRTLKCKLHETQTKLTTLPEEVLLSSALYRELQTLLRNAQQDLQSSKEAMQALETEATALREDRAAFQQTVEAEAASRSEDLEKLIKAKEADVTRLRSQRDELNAELTERRSREQVKFTQIEEMKALLNSKEERLILLSSQVRRLRMAVAAFHGQSAGVSALATAESEEDQFEQVSRAAQQAQARVAELEQRLGVAGQNASPNGTGATAKTEKGADVDTKAEKSVEAASESELQGEIQRLRLSLQAAEASSKAVDDELEKISAAYADLERQASVKVTDVSRMEEKALRWVTEKSKADNKYFSAMRAKDAVDAELRTAKQVHERQQKTIEAFADVERNYVVQSGLHEKAISTFKKVTDAQTHRIETLQRELELAESRLTELARVKEVASDSAKELINTANLEKDQRKRAEERIVRLEKDLESSKRQLAKAAASAAKNKGRRDADAGDGASEKDFLNALLQCSSCKERYRNRILTKCYHTFCSECIDSRVQTRQRKCPHCALAFAVSDVQPLYLQ
Protein
E3 ubiquitin-protein ligase BRE1: BRE1

Gene
bre1
Protein
E3 ubiquitin-protein ligase bre1
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
760 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
85.245 kDa
Sequence
MPVAEASPVASSEPGFVKMEDRKRAATSDHNDSAPPLKKQATSVNGGSKPHPDADMPWKDDLEVSLGLAGVVGFMSFQGGLRYPSSAEPTTSLTIKDAIWRQMQEYKREKVSLEAKLKDMSKAATRHNEHLRVIDTWYNQVCGSTLIDEVKLLLGAAEDIKGDRPTFQSSLSFDDVDNFEKHLKSRSNDIRDIISRLVKNTPKSPPEICELQSQLAKKLAEEKATIAELDKALSEKQQLEESLEEASLRYMVAEKKLDRARSLTVAKLEKQYILGPQRPGGDSASGQREEQSVSNGATPSAERGPELDEAHNKLVAISEKQKEQLQKLETENANLLSQITDLNIKRSKLTDDDYAHTDLFKQMRSQYDDVVKRINHLEATNVQLREEAVKLRSERTAYRNQVDEETQNVIAEKEAQLIRAETDLARIRNARDELLADQQMRKAAQEQEKTAVLKVQELAEARNAQIASLESEVERLRLQVENAKATQADSSDIPVEELRGKYQVLERQYAMLNTELTSMQTACKKYSTLASQKVTDFSALEEKMARLTAEKSKADQKYFAAMKSKEARDLEVRTLRMQNSKSSDIVSQLKESEAATRSLLANMEKQVSETKEALNSMMNKHHATQQQLAENGIVIEGLKGQINELKTLSTSKDATLASTSSACRQAETEIEGLKATLADTKKSLDNWKNKSLGNSSSEYEMLRTLALCTVCRRNFKNTAIKTCGHVFCKDCVEERLTSRSRKCPNCNRSFGNNDYMHITL
Protein
E3 ubiquitin-protein ligase bre1: bre1

Gene
bre1
Protein
E3 ubiquitin-protein ligase bre1
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
725 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
82.107 kDa
Sequence
MPATEASPVVCSESAIVKMEDRKRPATHDHNDSAPPLKKQATSVNGGSKPHPDADMPWKDDLERFQKDAIWRQMQEYKREKMSLETKLKEMSKATAYHNDHLRVIDAWFNQLIDEVKTLMGALDEDKDRPSFRSSLLFENMEDFEKHLKARSDDIRAIITRLQSFSINAPPEVTDLQSQLAKKLAEEKGTIAELEKALAEKQQLEESLEAASLRYMVAEKKLDRARSLTVAKLEKQYLLGAQRPGGDSASGNREEQSPVNGLPSSAERNTELEEAHKQLVAVSEKQKEQLQKLESENANLLSQITELNIKRTKPTDDDYAHTDLFKQLRSQYDDVVKRINHLEATNIQLREEAAKLRSERTAYRNQVDEETQNVIAEKEAQLMRAETDLARIRNARDELLADQQMRKAAQEQEKIATTKVQELADAAQARINALESEVDRLRLQLDNTKAAHTEIDDVPLEELRAKYQNLERQYSMLNTELTSMQTACKKYSLLASQKVADFSALEEKVARLTAEKSKADQKYFAAMKSKEARELEVRTLRIQNSKSSDIVSQLKESEATTRSLLANMEKQASETKEALNSIISKHHAAQQQIAENNIVIDGLKAQVNELKALSVSKDSSLASASSACRKAETEIESLKVTLADTKKSLENWKNKSLGNSSSEYEMLRSLALCTVCRRNFKNTAIKTCGHVFCKECVEERLTSRSRKCPNCNRSFGNNDHMHITL
Protein
E3 ubiquitin-protein ligase bre1: bre1

Gene
BRE1
Protein
E3 ubiquitin-protein ligase BRE1
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
703 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
80.21 kDa
Sequence
MEDRKRPAISSADEIAPPSKRVAVNGSKAKDDPLDMKEESWVEAYTKGAIYRQMQEYSRKASTYESRLEELHKRSVHHDDHLRIIDAWWRQVLDEMELLLADSGVTSQTPSEPPYLSSVSFKDLHDFQKHLSEKGKGIKLRAEAILARLASSRGSIKPDAAKLESKVAGLLAAQKEYFAKLDRLKTEKDQLSEQLNAATLRYFKAEKKLDRAKSSQVQKMEQQAFANATRPSASGDVNTDSGETNGNSGELLLKYEEATAAATKQKEQLDVFLAEIKALQDENSTLKAKRDTLTDEDFIRTDVFKQFKNQNEDLIKRINTLEATNKQLREEAERLQAERTAFRTMLEADANQVTQELESEIILRDQDLARVRSARDELLAETTQHKARLDQERASVEQVKALASAKEDRITALESQLSRLQQSETQQAVSPDIEALTVEELRLKYTKLQQDFDSINMELPAIEKAYKKMKELAHRKAMDFSATEERMSILIAEKSKADQKYFAARKDADTRNNEIRSLRHQNSKSSEIIAQLKDLESQNRVLLGNLEKQLTDLKQSNASLMTENKKMEVTSLDAVRRTESLNKQVSDLSNLVKSKDAASAVVRERNVMQETEVEKMKVRLEHAQKDRDNWKNKALSNSSEEEEMLRTFALCTICRNNFKNTALKTCGHLFCNQCVDDRISNRMRKCPTCSRAFDKMDVMPVHH
Protein
E3 ubiquitin-protein ligase BRE1: BRE1

Gene
BRE1
Protein
E3 ubiquitin-protein ligase BRE1
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
700 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
78.824 kDa
Sequence
MEDKRNAESASLGASSGGDSKRARVAARPVSLEDVAEFQKEAIFRAMETYRREKETLEKQLETQGEKERELEERVVRLGTWWDKVADRLALVVGKYEFEKSKVKTEDVKKEEDTERDAGDEDEVEVAPGPTGLATDLELEEKSASISSHFSTLLDLIGDKISKQDKTEVSRLSAGYTDMAEQRHLLVRKIQDLEHEAQTMKNQYLAAAKKLDRYKSPTVKLIEGEDVEEKAEENGDQKTAQMEEKKETEDSPDTKDTGDTKALRETIQVQEEQMKELDAKIAALEHEASLFNAKMADLSESDLLDHSGAFKAAKEQLSDKTGQILALEKSRDAISAEKMALDENRQQYRSTIKREFEKRESELRSQLSRAETDLVRIRTARDEILADLSQKKATEADKLKTIESLKELGEVYKLRIGTLESEVQRWRKEGNEGVNMSSNVEGKSLEELKKEVTVLTLTNQSLMAEIPGMEAAFVSAQKMAENKALDVADRESRLTKLLAEKAKADEKYFAAMRHKDALGAENAKLKAQMVKSSELVNQLQEVDAKTRAKIDVLEKTLSEYVSLHAKQQEAAKRLTSQVAEKTHMLNGAQKYLTTLKEEMKQQGTKLSVGEHRARKLALDNAKLTKQIELSSFGGSSDEIDELRSIAMCSLCSKNWKDTALKVCGHVFCHQCAQDRLDARLRKCPNCNKPFSQNDLLTVHL
Protein
E3 ubiquitin-protein ligase BRE1: BRE1

Gene
BRE1
Protein
E3 ubiquitin-protein ligase BRE1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
700 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme RAD6/UBC2. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. Also modulates the formation of double-strand breaks during meiosis.
Similarity
Belongs to the BRE1 family.
Mass
80.692 kDa
Sequence
MTAEPATKKIKLELSDPSEPLTQSDVIAFQKEALFRCINRRRVDFEALRKQYELSRRECIDVSRKLANIMALIVTLARFIETFCTDANEKQLCREIAQGDETLIVQRSDSFMKLLTKYGKPNTTDSNTNSNASDHIQELTTELKNLRKSKEELFYENSQLTEEISALKEYYTNIIRKYDRDESFTIKRVFKEDKTDAVKELREDEKESNENNIKSGNKDSSAINGDNTSKKSEKGDELVQAEDERKEDAENEKLELDLKFSDLRAEINSLSSTIKDLENIRRENEEELIKTRSEVSNLKKQQIAAADQDPDFKSYDHESLLAKIQHLTEQNAELSEINSSFLSKFQVLAKEKEIYTKKVREEFQKSLDSLVEMNSSLEKDVVRIRTARDDLLSKIAILEAEKSKTEVLSDLQHAIDILKEQWTKIDQRSNDTKSSSTQDALIKEIQDLEKGFRELSDLTHKKYSEIINHESVISKLTVEKTKADQKYFAAMRSKDSILIEIKTLSKSLSKSNELILQLKDSDRLLQQKIGNLHKQLDLSQNNERRLIDSSKTETLKIIDLNNTSTKLKRSLEKLQEESNKSIADMTHLETKLNDTEIELKHFKQKASHLESKCEKLHDTLFRGNNKNKGSSDEALVEELANFRTLVYCSLCSKNWKNMAIKTCGHVFCENCCKERLAARMRKCPTCNKAFSSNDLLTVHL
Protein
E3 ubiquitin-protein ligase BRE1: BRE1

Gene
BRE1
Protein
E3 ubiquitin-protein ligase BRE1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
693 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
79.771 kDa
Sequence
MSSEEPPIKKQKLELSDPDEPLTQHDVISFQKEALFRCLNSKRVELEALTKQYSTVHDKWEQNVHTLATLMSVLSTAASHLRGLCNEESEKTLCDEMINAGESVDKERTDEFLNLLRKYTNSNGSSDSKIDSLGLELQRANKTKSELRLQNKKLTDEIDSLKAYYHGLVRSYDREDSMTVKRVFNKQKTDDNTDNISNTEQRPTSVSPVLTNGATHVKNEVKTEQEALNNHTDSSQSSGITEEEKKKLFLQYENKITDLESHNSSLNRIIEELENYKQLNEKELAQTRLEISNLLSEKHSNEEEREDLLHQIEKLKASNTDLTLTNESFLSKFQELAKEKDTFQEKISSDFEKTLESLKAQNLALEKDLVRVRTTRDELISKVAILEAETSKSVLISDLKQALDILRDQWEKIEFRNNQSPSSDALLKEIQDLESAFKELSSLTHKKYSEYLNHESVISKLTIEKTKADQKYFASMRSKDSILVENKNLSKSLNKANELILQLKDTDKLYKQKIESLHKQLALSQNNEKRLVDSNKAANLKVMNLNSEIQKQKKLLDFTSSQKNELINELTEANGMLKSKELEIEFKENELQTALKKNEKLEEFLSKENYNMNKPSSLATTNLDEDSMAEELENFRTLVYCSLCSKNWKNMAIRTCGHVFCEDCCKERLAARMRKCPTCNKPFSSNDLLMVHL
Protein
E3 ubiquitin-protein ligase BRE1: BRE1

Gene
BRE1
Protein
E3 ubiquitin-protein ligase BRE1
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
691 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
79.669 kDa
Sequence
MDHDNDKKRLHEDSDNSEIKKHKPLDVLSEDGPLTQKDVVYFKKEAIWRQMRSYKQKCTLLTRDLNDIKSNYESNERKINVLDSWYESIINLFGVKKESNVELNETILIQLTNVPIGDLDALLEKRRAQLLTILSPIIENSKLSNIDKSDVLEKIEVLNAEVATLKSENNTLSKLKSQFESKVEDLQAQLLTLVKDNDRRSSKTLQRIDESLTNGSDVKEEASETVKSEVNKDTTVKNENSVDNEEFERISSEIEELKSDNRLLKESMNQINTNYDKVVKENLQLSDKLENLNENDLINSVSYQELAAHNKQLNESVNNLQKINDTTVNKLNELENKQTNVKHLLDKELREENETLKQQLQKSENDLVRIRTARDELLSKQTILKADFENQTTNDELNKLNKVLNERINALESERHETGDNSKISELSKDELIQRINMLNSEIKEIEQAFQETRENSLSKLMSVTDQENMVKKLTIEKTKADQKYFASMRLKDSLSSENKILKTQINKSQELVSKLNDLEKSYLDKIEILTKSNNDFKIIRQSALQENSKLQESLRAIDVRKASLEKELSGMKDKYSDKVQENTSFTQELNEKNLMMGKLEHKLKSTESLLKKYKTNNTSSILQEDERQLEALRSIAKCSVCSKNWKDTAITVCGHVFCSGCTQERLAARLRRCPTCNKGFSANDLLSIHL
Protein
E3 ubiquitin-protein ligase BRE1: BRE1

Gene
BRE1
Protein
E3 ubiquitin-protein ligase BRE1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
681 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
78.522 kDa
Sequence
MAVDNEKKRSTPDSLNSPHAKKSKPMQELSESGPLTQADVVYFQKEAIWRQMIQYKQQMMSMRSELIRLQRESDASKHIVTVLTAWYEQILALFDELNSEETSDLLLAITKNDDEQLDLIRKKLSNLISSKVTFDSAKYEKVSGELALLSRQNEQMTEEKRSLGERIDELESKITELAKEHERAQSKTLKRLDSQRHIKTEEDEQSTTKEENPQPNGHHKENDKTAVVDSEELDNLKCELDKLKTANQLLVQQVEQLTKENQSLIQKSLNLENKLHNLEESDLEDNTYYKKIVKNNQSLQEQIGKLTKLNSSNVSRLNELERQQNDLKSVIEGEIIEENEKLKQQLQESENNLVRIRTTRDELLSKNNILTSQLQDQKTNESLVELNNVLSKRVESLTEERLEAIVGTPGTGKLEDLSQQELIHKISQLNNEIKEVELAFKQTREITLKKLTSSIDQENLTKKLTIEKNKADQKYFSAMRVKDSLTNENKLLKAQIAKSQDLIKNLNDLEKKYLNKIDLLSNQLVDFRIIKENSLAENSKLHDELKTLNIAQDALHQEVERVNAKLESTLKEHTDLQESNKKRELELAKLQKQLQSTENILQKYKTNNTNSLLQEDEQQLEALRSIAKCSVCSKNWKDTAITVCGHVFCSKCTQERLAARLRRCPSCNRGFSANDLLSIHL
Protein
E3 ubiquitin-protein ligase BRE1: BRE1

Gene
BRE1
Protein
E3 ubiquitin-protein ligase BRE1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
663 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
75.282 kDa
Sequence
MNDHFVKRPKLELSDPSEPLTQKDVIAFQKEALFRCLNKWRVKANQLVEENEVLAAGLSKTTESVSGCCSSIVVLARSVVEDCSDEQDKRFLQQLINTEDEHTLTQIISNNSARICELILKTSGSNISDNIGRLQELESLTLTLQKLLKSSENKLKKATEYYENIIAQYDRQDSESVSRVFNTADDDSNVKKEKQSSTGASSVNDESNDNSDKSQSNKESAVSQAHHEIEINDLNTQISVLEATVKELTEWKNQNERELSELRQTVASNKSALSNNQLQSNSQHQPDASVTNEKISSLTKQNEQLQQINEGYLTKFQQLSADREIFNNKLTSEFNLAQETLKKHNASLEKDLVRIRTIRDELLAKVSLLEAQKTKSEMLEDLEKSLNIQQEQLQKFESRSSENASQDALMKELQDLEKAFREVSHLSNKKYAAYLNQESVLSKLTVEKTKASEKYFAAMRSKDAIMIENKNLSKNLNKSNELIVQLKDLEKTLQQKIVNVHMQLSLSQENEKRVKESNKETSMKIVELTSENNKLKKSTERLESETRNLIGTKTELESKIKDKDIENKQLKIKVSSAEAKSKKLYKTLLSNGGDNGALAEELENFRTIIYCSLCSKNWKNTALKTCGHVFCDVCCKERLAARMRKCPTCNKPFSSNDLLSIHL
Protein
E3 ubiquitin-protein ligase BRE1: BRE1

Gene
BRE1
Protein
E3 ubiquitin-protein ligase BRE1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
643 amino acids
Function
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Similarity
Belongs to the BRE1 family.
Mass
72.13 kDa
Sequence
MEEPAAKRPKLSDRSEPLTQRDVVLFQKEALFRQLNRYRAEARAGQVQVEELRRAHGQVGERLAAVCGVVRSVARAVADARGDGDARALCERVAGGDDDEVVARAAEFAAVVAGGLGRGAAAGEGWHRLEAVNSRLAAENAQLAAELGAVRGFYAELLRRYDRDESETVRRVFKVEESEPPRAATPVEESSAKGAASDGEAATAVVEREMQIEELQTEIRVLEDTVAQLTDWKRLNEQELTKLRQMASSAELSQRHPTPPSSSNLSADLQVLRSKVEKLSHENKELAQLNEAYLGKFQQLSADREIFNNRLSAEFQTAQETLKKHNSNLEKDLVRIRTARDELLSKVAVLEAQKSKSDMLEDLEKMLALQQEQLKALSEHKPEPARDAVMKELQDLEKAFKELSQYSNKKYSEYVNQESLMSKLTVEKTKADQKYFAAMRSKDSILIENKNLSKNLSKSNELIQQLKDIEKSLQAKIENLNKQLHISRINEKRLLDSNKTTSLKIMDLTSQLSKANKSSTLVQQECNKLIEEKAKMESKLNDLEIETKNLATKLTYQENKSKKLHKTLVSNGGDNGALAEELENFRTVVYCSLCSKNWKDTVIKTCGHVFCADCCKERLAARMRKCPTCNKGFSSNDLLVVHL
Protein
E3 ubiquitin-protein ligase BRE1: BRE1