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BIN4

Gene
BIN4
Protein
DNA-binding protein BIN4
Organism
Arabidopsis thaliana
Length
454 amino acids
Function
Component of the DNA topoisomerase VI complex. Binds to DNA. Required for chromatin organization and progression of endoreduplication cycles. The loss of BIN4 activates the ATM- and ATR-dependent DNA damage responses in postmitotic cells and induces the ectopic expression of the mitotic G2/M-specific cyclin B1;1 gene in non-dividing cells.
Mass
49.485 kDa
Sequence
MSSSSREGSPDWLRSYEAPMTTSLLSLSSSDDDSPYRESEVISSLPLPDDDGDDIVVLETESVELLTRKNSETKVVTKQVSIEQVFSRKKKADASLNLEDSCAGKENGNNVDCEKLSSKHKDAQGGADSVWLVSSDSEPSSPIKQEVTVSTEKDADFVLEATEEEPAVKTVRKEKSPKTKSKSSRKTPKEGNSAQEILKTEDKDTDTTIAEQVTPEKSPKTKSKSSRKTPKEENCAQEILKTEDKDKDTDTDTIIAEEVTTDQKIKPSSGSSSRLPLVLSEKVNRTKVLVECEGDSIDLSGDMGAVGRVVVSDTTGDMYLDLKGTIYKSTIIPSRTFCVVNVGQTEAKIEAIMNDFIQLIPQSNVYEAETMVEGTLEGFTFESDDESNKNAKTAVKPADQSVGTEEETNTKAKPKAKAKGETVIGKKRGRPSKEKQPPAKKARNSAPKKPKAKK