BIN2

Bridging integrator 2

565 amino acids

Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.

61.874 kDa

MAEGKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLADQAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVSTSENPQL

Bin2

Bridging integrator 2

507 amino acids

Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation (By similarity). Plays a role in podosome formation. Inhibits phagocytosis.

55.118 kDa

MAEGKAGGAAGLFAKQMQKKFSRAQEKVLQKLGKTVETKDERFEQSASNFYQQQAEGHRLYKDLKNFLSAVKVMRESSKRVSETLQEIYNSDWDGHEDLKAIVGNNDLLWEDYEEKLADQALRTMENYVSQFSEVKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKMAKAEEDFSKAQVVFEDLNQELLEELPVLYNSRIGCYVTVFQNISNLRDVFYREMSKLNHSLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVQTCTAFSPVSPVTSPTSPNALSVTSESESVSATAEELTSEAVGEDSCESEESLKDEEADEDQSETSSSEEEEDEDEDEDEEESLAACNGPTPTPAPTPAPASPAAEVKSQEEAAPCSPTSSLGRGQTGKEHSPPGEVVLRARASSEGAEQSKRTASVQRTSAPPSRPPPPKASGGGLSSPPGSAEASKACHPRASSDASSDPEPPETGEKEGTGSSGPKEPHASSTKSATQVVSNDENTEL

Bin2

Bridging integrator 2

489 amino acids

Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Inhibits phagocytosis (By similarity). Plays a role in podosome formation.

52.554 kDa

MAEGKAGGAAGLFAKQMQKKFSRAQEKVLQKLGKTVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEVYSSDWDGHEDLKAIVGNNDLLWEDYEEKLADQALRTMENYVSQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDDAKMAKAEEDFSKAQIVFEDLNQELLEELPILYNSRIGCYVTVFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVQSCAASSPVSPVSPVSPVTSPTSPSATSEPESVSATGEELTSEAGGEDSCESQESLKDEEADEAQSETSSSLPACNGPTPAPASPAAEVGSQEEALSSSAQSPGRGQTGKDTPSPGDVVLRARASSEGAEQSKRAASIQRTSAPPSRPPPPRASGSGSCNAPGSPEGSSQLCSPRASPDASSNPEPAETREKEGAGSSGPEEPRAVSTKSATQASGGLVGLFL

BIN2

Bridging integrator 2

476 amino acids

51.18 kDa

MAEGKSGAGLFAKQVQKHFSRAQEKVLQKLGKTVETKDEQFEQSAYNFQLQQNEGNKLYKDLKAFVGAVKVMHESSRKVAETLQEIYSTEWDGHVELKAIADSNDLLWDDYEAKLGDQALRLMENYLAQFGDIKERIAKRGRKLVDYDSARHHLEALQNAKKKDEAKIAKAEEEFNRAQVVFEELNRELREELPVLYGSRIACYVTIFQNISNLRDIFYKEMSKLNRDLYEVMGKLDKQHSSKVFIIKGVPSKRRSLLISAPVSPPAAYPCPGKAPNWEPSSGAEQTPTSPRVGSDATEDVPNGLAAPGPAEPGAPMPGPPPASPTSVRSASESESECSGESREIDLSPKEMEVSAGSGCPEYPKTEGAAKGEVEGIAASMASMIVSEAIAAATGAAPGDSDGVGGGDSTDSEISPAEGAWGGPSPGGSEERVEGTDVSPEVGSDAGPCEHGTPEPPEQDVSCNPPQDPSESLTPL