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BEX2

Gene
Bex2
Protein
Protein BEX2
Organism
Mus musculus
Length
129 amino acids
Function
Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity).
Similarity
Belongs to the BEX family.
Mass
15.452 kDa
Sequence
MESKVEQGVKNLNMENDHQEKEEKEEKPQDASKRDPIVALPFEAGDYYVPRGGRRRFRVRQPIVHYRWDLMHRVGEPQGRMREENVQRFGDDVRQLMEKLRERQLSHSLRAVSTDPPHHDHHDEFCLMP

Gene
Bex2
Protein
Protein BEX2
Organism
Rattus norvegicus
Length
129 amino acids
Function
Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity).
Similarity
Belongs to the BEX family.
Mass
15.541 kDa
Sequence
MESKVEQGVKNLNMENDHQEKEEKEEKPQDANKREPVVALPFEAGEYYVPRGSRRRFRVRQPIAHYRWDLMHRVGEPQGRMREENVQRFGEDMRQLMEKLRERQLSHSLRAVSTDPPHHDHHDEFCLMP

Gene
BEX2
Protein
Protein BEX2
Organism
Bos taurus
Length
128 amino acids
Function
Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity).
Similarity
Belongs to the BEX family.
Mass
15.236 kDa
Sequence
MMPKEEQVLKNLTMENANEENEKKDEKEQDANKGEPLALSLGAGEYCVPRGNRRRFRVRQPILHYRWDMTQRLGKPQARMREENIERIGEEMRQLMEKLREKQLSHSLRAVSTDPPHHEHNDEFCLMP

Gene
BEX2
Protein
Protein BEX2
Organism
Homo sapiens
Length
128 amino acids
Function
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.
Similarity
Belongs to the BEX family.
Mass
15.321 kDa
Sequence
MESKEERALNNLIVENVNQENDEKDEKEQVANKGEPLALPLNVSEYCVPRGNRRRFRVRQPILQYRWDIMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHHDEFCLMP