Protein
Probable triacylglyceride transporter BCG_1471c
Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Function
In association with lipoprotein LprG probably transports triacylglycerides (TAG) across the inner cell membrane into the periplasm; TAG probably regulates lipid metabolism and growth regulation (By similarity). Confers resistance to several drugs such as rifampicin, clofazimine and novobiocin; is also part of the oxidative stress response and is needed to maintain normal growth characteristics (PubMed:19564371). Probably an efflux transporter, involved in maintaining correct cell wall permeability. Probably required with LprG for normal surface localization of lipoarabinomannan (LAM) (By similarity). Required for optimal growth on cholesterol (PubMed:26155739).
Similarity
Belongs to the major facilitator superfamily.
Sequence
MRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMNSVGIPINQLHRITWIVTMYLLGYIAAMPLLGRASDRFGRKLMLQVSLAGFIIGSVVTALAGHFGDFHMLIAGRTIQGVASGALLPITLALGADLWSQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLLHDWRDVFWINVPLTAIAMVMIHFSLPSHDRSTEPERVDLVGGLLLALALGLAVIGLYNPNPDGKHVLPDYGAPLLVGALVAAVAFFGWERFARTRLIDPAGVHFRPFLSALGASVAAGAALMVTLVDVELFGQGVLQMDQAQAAGMLLWFLIALPIGAVTGGWIATRAGDRAVAFAGLLIAAYGYWLISHWPVDLLADRHNILGLFTVPAMHTDLVVAGLGLGLVIGPLSSATLRVVPSAQHGIASAAVVVARMTGMLIGVAALSAWGLYRFNQILAGLSAAIPPNASLLERAAAIGARYQQAFALMYGEIFTITAIVCVFGAVLGLLISGRKEHADEPEVQEQPTLAPQVEPL