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BCCIP

Gene
Bccip
Protein
BRCA2 and CDKN1A-interacting protein
Organism
Mus musculus
Length
316 amino acids
Function
During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity).
Similarity
Belongs to the BCP1 family.
Mass
35.942 kDa
Sequence
MASKAKKRAVGNGIQRPLGAPGQREEEEEEEDEVEDEEEDEDDSDEEEDEVDEIVDEEVNIEFEAYSISDNDYGGIKKLLQQLFLKAPVNTAELTNLLMQQNHIGSVIKQTDVSEDSDDEVDEDEIFGFISLLNLTERKGTQCAEQIKELVLSFCEKTCEQSMVEQLDKLLNDTSKPVGLLLSERFINVPPQIALPMHQQLQKELSEARRTNKPCGKCCFYLLISKTFMEAGKSSSRKRQDSLQQGALMFANAEEEFFYEKAILKFSYSVQGESDTRLGGRWSFDDVPMTPLRTVMVIPDDRMNEIMETLKDHLSV

Gene
BCCIP
Protein
BRCA2 and CDKN1A-interacting protein
Organism
Homo sapiens
Length
314 amino acids
Function
During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
Similarity
Belongs to the BCP1 family.
Mass
35.979 kDa
Sequence
MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIEFEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMDEDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAGKNNSKKKPSNKKKAALMFANAEEEFFYEKAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDKMNEIMDKLKEYLSV

Gene
bccip
Protein
Protein BCCIP homolog
Organism
Xenopus tropicalis
Length
310 amino acids
Function
During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. May promote cell cycle arrest and DNA repair.
Similarity
Belongs to the BCP1 family.
Mass
35.488 kDa
Sequence
MASNAKRRALEPERLPERNEEEEDDMEGDNSDESDDIEDDESEEEEEVNEEVNIDFEAYTISDTDSEGIKKLLKQLFLKAHVNISELTDLLIQQNHIGSAIKQAESQEDSDDDDDDDVDHVFGFISLVNLTERKGTSCVEQIKELILTRCEENCEQSMVEQFDKVLNNNSKPVGFLLSERFINVPAQIALPMHQQLQKELADTQRTNKPCGKCYYYLILSKTFVEAAKTSKGRVGSQAKEELMFANAEDEFFYEKALLKFSYSVQEESDTQLGGRWSFSDVPMKPLRTVMLVPADRMNSIMDKFKEYLSV

Gene
bccip
Protein
Protein BCCIP homolog
Organism
Xenopus laevis
Length
308 amino acids
Function
During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. May promote cell cycle arrest and DNA repair.
Similarity
Belongs to the BCP1 family.
Mass
35.172 kDa
Sequence
MASNAKRRALEPERLLEKHKEDEEDMEGDESEESDDIEEDESEEDEEVNEEVNIDFEAYTISDADYDGIKKLLKQLFLKAHVNISELTDLLIQQNHIGSAIKQAEGQDDSDDDEDDDHVFGVISLVNLTERKGTACVEQIKELILSRCEENCEQSLVEQFDKVLNDNSKPVGFLLSERFINVPAQIALPMHQQLQKELADSQRTNKPCGKCHYYLILSKTFMEATKTSKGSVGSQAKEELMFANAEDEFFYEKALVKFNYSVQEESDTQLGGRWSFSDVPMKPLRTAMLVPAERMNSIMDKFKEYLSV

Gene
BCCIP
Protein
BRCA2 and CDKN1A-interacting protein
Organism
Bos taurus
Length
306 amino acids
Function
During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
Similarity
Belongs to the BCP1 family.
Mass
35.184 kDa
Sequence
MASRPKRRAVSRVPPALGDEEEEDEVEEQDEDDSDEEEDEEDEVVNEEVNIEFEAYSISDNDYDGIKKLLQQLFLKAPVNTAELTNLLIQQNHIGSVIKQTDVSEDSDDEVDEDEIFGFISLLNLTERKGTPCAEQIKELILRLCEKNCEKSMVEQLDRLFNDTARPVGFLLSERFINVPPQIALPMHQQLQKELAEAHRANKPCGKCYFYLLISKTFVEAGKSNSKKKRSNQKKDELMFANAEEEFFYEKAILKFNYSVQEESDTCLGGRWSFDDVPMKPLRTVMLIPGDKMSEIMEKLKEHLSV

Gene
bccip
Protein
Protein BCCIP homolog
Organism
Danio rerio
Length
301 amino acids
Function
During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. May promote cell cycle arrest and DNA repair.
Similarity
Belongs to the BCP1 family.
Mass
33.884 kDa
Sequence
MASSAKRRAVETGQNPQDSDESSDEGLEDSGDDDSENSEEEVNEEVIVDFEAHTISDNDFHGIKTLLQQLFLKCHVNTSDLTDIIIQQNHIGSVIRQAEVPEDSDDEGDPDEVFGFISMVNLTERQGVECLEKLKDMILDQCVKCSTPDGQERMENLLQGNAQSVGLLLSERFVNVPPQIALPLHKQLQKEMAEAQRTNKPSGKCQFCLMISKTCKPLKKKSISAGDQAKDELLFVNDEEECFYEQATVKFSYCVQDEADSCATGKWSYDDEPMKPFRTVMVIPMDRMDTIMQKMTDYLTV