Protein
Transmembrane emp24 domain-containing protein p24delta5
Organism
Arabidopsis thaliana
Function
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity). Interacts with p24beta2 at endoplasmic reticulum export sites for endoplasmic reticulum exit and coupled transport to the Golgi apparatus. Once in the Golgi, interacts very efficiently with the COPI machinery for retrograde transport back to the endoplasmic reticulum.
Similarity
Belongs to the EMP24/GP25L family.
Sequence
MAINRIAHGSLFLTVVLFFLTVNYGEAIWLTIPTTGGTKCVSEEIQSNVVVLADYYVVDEHNPENTPAVSSKVTSPYGNNLHHQENVTHGQFAFTTQEAGNYLACFWIDSSHHLANPITLGVDWKMGIAAKDWDSVAKKEKIEGVELQLRRLEGLVLSIRENLNYIKDREAEMREVSETTNSRVAWFSIMSLGVCVVVVGSQILYLKRYFHKKKLI