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AUNIP

Gene
AUNIP
Protein
Aurora kinase A and ninein-interacting protein
Organism
Bos taurus
Length
357 amino acids
Function
DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.
Similarity
Belongs to the AUNIP family.
Mass
39.634 kDa
Sequence
MRRRGPEKEEEACGVWLDAAALKRRKTQTQLIKSSTKMLTLLPGERKAKISFTQRSCPSAGTRQTSIASFLTSQQGKTNGADQRSVSSHTESQTNKESKEDATQLEHLTQGLRADFMAPPLATSTPADIQEARLSPQSLKASCQHGIGTPYLTVPCLFRPDTSVCAGASKASLACSFAHDLESSCLLDQKEGEDSSCEREWLQGSKKNNYQSVERHSKTTGHKGHQLLDKTNLENVSAKRSRQAPVLQTYKDSRRGANMKAVKQSSCPIPGFSWDSERNDKDSWSQLFTEDSQGQRVIAHNSRAPFRDVTNDQNQGYGRVPNSLWAQCQDRTTQFNLQPDSLFTQDSEGNQVIRHQA

Gene
AUNIP
Protein
Aurora kinase A and ninein-interacting protein
Organism
Homo sapiens
Length
357 amino acids
Function
DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561). Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561). Inhibits non-homologous end joining (NHEJ) (PubMed:29042561). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670).
Similarity
Belongs to the AUNIP family.
Mass
40.253 kDa
Sequence
MRRTGPEEEACGVWLDAAALKRRKVQTHLIKPGTKMLTLLPGERKANIYFTQRRAPSTGIHQRSIASFFTLQPGKTNGSDQKSVSSHTESQINKESKKNATQLDHLIPGLAHDCMASPLATSTTADIQEAGLSPQSLQTSGHHRMKTPFSTELSLLQPDTPDCAGDSHTPLAFSFTEDLESSCLLDRKEEKGDSARKWEWLHESKKNYQSMEKHTKLPGDKCCQPLGKTKLERKVSAKENRQAPVLLQTYRESWNGENIESVKQSRSPVSVFSWDNEKNDKDSWSQLFTEDSQGQRVIAHNTRAPFQDVTNNWNWDLGPFPNSPWAQCQEDGPTQNLKPDLLFTQDSEGNQVIRHQF

Gene
Aunip
Protein
Aurora kinase A and ninein-interacting protein
Organism
Rattus norvegicus
Length
347 amino acids
Function
DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.
Similarity
Belongs to the AUNIP family.
Mass
38.244 kDa
Sequence
MSRRGPEEEACGVWLDAAALKRQKMQTHLLKLGTKMLTLLPGERKPSIPFTQRRATRQTSITSFVTSQPGMANGGNQKNASSLKENQINRECKSRSQLDCLDQGLEDDCLVSPLATSTPADIREAGHSPQSSQISGCQSLETTSLTMMSFPQPVVLMGTGESKAPLASSFTQFLERSCLLDQREAKRKREGLCGSKTDCPGMGSHIRPPGGKCHQPLDKAKVEKRATAKENRQAPVHLQTYRFGSHSGKKTLLVTKSPCPLSVFSWDIDRKDRDSWSQLFTEDSQGHQVIAHSTKMPFQDVTNARNQGSGQFPDSPQAQGQDGPTLLHLQPHLLFTQDSEGNRVIRH

Gene
Aunip
Protein
Aurora kinase A and ninein-interacting protein
Organism
Mus musculus
Length
340 amino acids
Function
DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.
Similarity
Belongs to the AUNIP family.
Mass
37.684 kDa
Sequence
MRHRGPEEEACGVWLDAAALKRRKMQTHLIKLGTKMLPLLPGERKPNDPFTQRRGTRQTSIASFVTLQSGMASGGNQKNIFSLKENQTNKECKRTQLDCLDDGLLSPLVTSAPADIQEAGHPRSPQISGCQGLEMSSLTMMSLTQPDVLMGTGESKGPLDSSFSQYLERSCLLDQREAKRKGEGLRESKTDCPGMGSHIRPPGSKCHQPLDKAEMGKRGPTKENRQAPVHLQTYRSGSCSRKKTLLVTESPCPLSLFPWDSERSDRDSWSQLFTEDSQGQQVIAHNTKMPFRDVTNARNQGSGQFPDSPQAQGQDGPAQLHLQSYLLFTQDSEGNRVIRH