About Services Plasmids Contact

ATX2

Gene
Atx2
Protein
Ataxin-2 homolog
Organism
Drosophila pseudoobscura pseudoobscura
Length
1121 amino acids
Function
Regulator of actin filament formation, though it does not directly assemble with actin filaments. Required for oocyte specification and oocyte positioning in the female germline. Also required for normal eye development and bristle morphology (By similarity).
Similarity
Belongs to the ataxin-2 family.
Mass
120.519 kDa
Sequence
MNNNSKRKTRPSGGGGGGGASGGISRYNANDNSLRPANNKSGAAGNSAGAGAGTGGTAIRPVAQGVYNNTFFMHSATALVGSVVEVVLRSGNIYEGVFRTFSGNFDIALELPACIKSKNLPEEGKVPKHIIFPADTVVKIVAKDFDSQYATAGAFKTDEAISDKCNGARLDEKELEPWDSGANGDIDIELDGAANGWDANEMFRKNENTFGVTSTFDDSLATYTIPLDKGDSLEFKEAEAKAEKLAAEIENNPTCRDRLDLENGDEEALFAAVERPEQDHRRDGDRERERNDRDREREERDRDRDRDRGNKPPRGAGDFQLRETMSSDRYITKQTRGPQMSHVSMSSQGGGGGGRDRDNGLMMPGVISGGGAGQGGATQSAAVLLLAGGLKASGPASSANAAGMDASGKYSMVKRKTVTQGGKVMRGNVPPNSSGGGNISAVQGGNGNPVGQSKGGYQPTMVMQNQYAYQGNSQIMHGSSQYRNPSHMSGGPSKLNGDANANTNKPLPQRQIRQYQGSQSNSLNYGGEPQPQMGKPMHSSHGGHPGQNSNSPPLQTGGQPQQQQQQQQQQQQQQAPQQQQHQNMAPQGQQPQPQRQMRSRDNQLQDLRQFGQDFQLAPTNNSPPQQQPQQPQQQQQQQQVQVQVQAQVQQQQQRALLQSASPPQQQSQQQQQQQQQQHVPMQHQGPPPHLHQAALSQPHYVPQPQQQQPQPQQQPPPPQQQQQQQHVPLHLQQKAQQPPQQQQQLVETQHQLVPKQHQQPPAQQQQPQLAPEPSQQPLPLYHPMPPPQTSPVVITSPVLLEAPPPQILTAQQPPQQQQLAATPKPDASPAPGSNTTTPTGIVSTPTTAAASSAGSEKSTPAAASSGATSGTAAAAVGATGATGSTGSTPVVKKHVLNPSAKPFTPRAGAGTPNPSRPHTPQTPVPMPGIYTTTGTHVPAAATNQPIYVVQQQHPFPPPTHPQAGQPPRLRRNNYAPMGASQMHVSATTATGQPLMAAGPMTQFIQYPHAPQQHFQSQGYAPMPMRLYPDQQPQLQFLTQTPQSTTPSPGQPHQPFHPPPQPSPAGGGPQPAYTPPTQQTYQLMCLHSQHVLPNPYFQPQPTPHHAPQNPQYQIVMQQHHAQ

Gene
Atx2
Protein
Ataxin-2 homolog
Organism
Drosophila melanogaster
Length
1084 amino acids
Function
RNA binding protein that regulates various processes including circadian behaviors, actin filament formation, eye development and oocyte formation (PubMed:12524342, PubMed:28388438). Forms a complex with tyf and pAbp which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12 or me31B (PubMed:28388438). Forms an activator complex (Atx2-tyf activator complex) via association with Lsm12 and activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian locomotor behaviors (PubMed:28388438). Forms a repressor complex (Atx2-Not1 repressor complex) via the me31B-dependent association with Not1 to promote Not1-dependent post-transcriptional gene silencing and support high-amplitude circadian rhythms in a per-independent manner (PubMed:28388438). Regulates actin filament formation, though it does not directly assemble with actin filaments (PubMed:12524342). Required for oocyte specification and oocyte positioning in the female germline (PubMed:12524342). Also required for normal eye development and bristle morphology (PubMed:12524342).
Similarity
Belongs to the ataxin-2 family.
Mass
117.578 kDa
Sequence
MNNNSKRKTRPTGGGASGGISRYNSNDNSLRPTNNKAGAGGGNGGAAVRPSAQGVYNNTFFMHSATALVGSVVEVRLRSGNIYEGVFRTFSGNFDIALELPACIKSKNLPEEGKVPKHIIFPADTVVTIVAKDFDSQYATAGAFQTDGAISDKCNGARPDEKELEPWDSGANGDIDIELDSAANGWDPNEMFRKNENTFGVTSTFDDSLASYTVPLDKGDSLEFKEAEAKAEKLAAEIENNPTCRDRLDLENGDEEALFAAVERPSTEQDQRGDRGDRERNDRDREREERDRDRDRDRGNKPRGAGDFQLRETMSSDRYITKQTRSITGPQLSHVGMSSQGSGRDRDTRGDGSMMMQSGGGSGQGGSTQSTAALMLAGGLKGVGPAPSANASADSSSKYSGGSMVKRKTVPQGGKVMRNNVPTGGSNVSVSQGGNGNSVGQNKGGYQPSMGMPSQYSYQGNSQIMHGSSQYRNQSHMGGANKLNGDSNANTNKPLPQRQMRQYQGSQSNSSLNYGGEPQSLGKPVHGSHGGHPGQNSNSPPLQTAGPQQQQQQQQQQQQQQQQQQPPQQQQHQNIQPQGQNTQPARQVRTRDNQMQELRQFGQDFQLAPSNTSPPQQQQQQQQQQQQHQVQQQQQRALQQSASPPQQQQQQQQQQQHVVLHQVPQTHLHQAALSQPHYVPQQQPQQAPLPQQQHVPHHMQQKAQQQQLVETQHQHVQKQHQSQPQVQQPPPQLLQDPSQQPLPIYHTMPPPQTSPVVVTSPVLLEQPPPQPMPVVQQQQTQQLATPKPEVSPAPPSSNTTTPTGIASTPTAGVIASAGSEKTTPAAPTPTSNSATVPTGTAATAGGATGTTPVVKKHVLNPSAKPFTPRGPSTPNPSRPHTPQTPVPMTNIYTTTGGHVPPAANQPIYVMQPQHPFPPQTHPQAGQPPRLRRSNYPPMAASQMHVSASAATGQPLITAGPIPQFIQYGHAPHQQQFQSHTYAPMQMRVYPDQPQQLQFMTQTPQSTTPSPGQPHQQFHPPPQPSPAGGGPQPAFTPPTQAATYQLMCVHPQSLLANHYFPPPTPQHPQQNQQQYQIVMQQHQPQ

Gene
ATX2
Protein
Histone-lysine N-methyltransferase ATX2
Organism
Arabidopsis thaliana
Length
1083 amino acids
Function
Histone methyltransferase.
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
Mass
123.287 kDa
Sequence
MISMSCVPKEEEGEDTQIKTELHDHAADNPVRYASLESVYSVSSSSSSLCCKTAAGSHKKVNALKLPMSDSFELQPHRRPEIVHVYCRRKRRRRRRRESFLELAILQNEGVERDDRIVKIESAELDDEKEEENKKKKQKKRRIGNGELMKLGVDSTTLSVSATPPLRGCRIKAVCSGNKQDGSSRSKRNTVKNQEKVVTASATAKKWVRLSYDGVDPKHFIGLQCKVFWPLDAVWYPGSIVGYNVETKHHIVKYGDGDGEELALRREKIKFLISRDDMELLNMKFGTNDVVVDGQDYDELVILAASFEECQDFEPRDIIWAKLTGHAMWPAIIVDESVIVKRKGLNNKISGGRSVLVQFFGTHDFARIQVKQAVSFLKGLLSRSPLKCKQPRFEEAMEEAKMYLKEYKLPGRMDQLQKVADTDCSERINSGEEDSSNSGDDYTKDGEVWLRPTELGDCLHRIGDLQIINLGRIVTDSEFFKDSKHTWPEGYTATRKFISLKDPNASAMYKMEVLRDAESKTRPVFRVTTNSGEQFKGDTPSACWNKIYNRIKKIQIASDNPDVLGEGLHESGTDMFGFSNPEVDKLIQGLLQSRPPSKVSQRKYSSGKYQDHPTGYRPVRVEWKDLDKCNVCHMDEEYENNLFLQCDKCRMMVHTRCYGQLEPHNGILWLCNLCRPVALDIPPRCCLCPVVGGAMKPTTDGRWAHLACAIWIPETCLLDVKKMEPIDGVKKVSKDRWKLLCSICGVSYGACIQCSNNTCRVAYHPLCARAAGLCVELADEDRLFLLSMDDDEADQCIRLLSFCKRHRQTSNYHLETEYMIKPAHNIAEYLPPPNPSGCARTEPYNYLGRRGRKEPEALAGASSKRLFVENQPYIVGGYSRHEFSTYERIYGSKMSQITTPSNILSMAEKYTFMKETYRKRLAFGKSGIHGFGIFAKLPHRAGDMVIEYTGELVRPPIADKREHLIYNSMVGAGTYMFRIDNERVIDATRTGSIAHLINHSCEPNCYSRVISVNGDEHIIIFAKRDVAKWEELTYDYRFFSIDERLACYCGFPRCRGVVNDTEAEERQANIHASRCELKEWTES