Atx2

Ataxin-2 homolog

1121 amino acids

Regulator of actin filament formation, though it does not directly assemble with actin filaments. Required for oocyte specification and oocyte positioning in the female germline. Also required for normal eye development and bristle morphology (By similarity).

Belongs to the ataxin-2 family.

120.519 kDa

MNNNSKRKTRPSGGGGGGGASGGISRYNANDNSLRPANNKSGAAGNSAGAGAGTGGTAIRPVAQGVYNNTFFMHSATALVGSVVEVVLRSGNIYEGVFRTFSGNFDIALELPACIKSKNLPEEGKVPKHIIFPADTVVKIVAKDFDSQYATAGAFKTDEAISDKCNGARLDEKELEPWDSGANGDIDIELDGAANGWDANEMFRKNENTFGVTSTFDDSLATYTIPLDKGDSLEFKEAEAKAEKLAAEIENNPTCRDRLDLENGDEEALFAAVERPEQDHRRDGDRERERNDRDREREERDRDRDRDRGNKPPRGAGDFQLRETMSSDRYITKQTRGPQMSHVSMSSQGGGGGGRDRDNGLMMPGVISGGGAGQGGATQSAAVLLLAGGLKASGPASSANAAGMDASGKYSMVKRKTVTQGGKVMRGNVPPNSSGGGNISAVQGGNGNPVGQSKGGYQPTMVMQNQYAYQGNSQIMHGSSQYRNPSHMSGGPSKLNGDANANTNKPLPQRQIRQYQGSQSNSLNYGGEPQPQMGKPMHSSHGGHPGQNSNSPPLQTGGQPQQQQQQQQQQQQQQAPQQQQHQNMAPQGQQPQPQRQMRSRDNQLQDLRQFGQDFQLAPTNNSPPQQQPQQPQQQQQQQQVQVQVQAQVQQQQQRALLQSASPPQQQSQQQQQQQQQQHVPMQHQGPPPHLHQAALSQPHYVPQPQQQQPQPQQQPPPPQQQQQQQHVPLHLQQKAQQPPQQQQQLVETQHQLVPKQHQQPPAQQQQPQLAPEPSQQPLPLYHPMPPPQTSPVVITSPVLLEAPPPQILTAQQPPQQQQLAATPKPDASPAPGSNTTTPTGIVSTPTTAAASSAGSEKSTPAAASSGATSGTAAAAVGATGATGSTGSTPVVKKHVLNPSAKPFTPRAGAGTPNPSRPHTPQTPVPMPGIYTTTGTHVPAAATNQPIYVVQQQHPFPPPTHPQAGQPPRLRRNNYAPMGASQMHVSATTATGQPLMAAGPMTQFIQYPHAPQQHFQSQGYAPMPMRLYPDQQPQLQFLTQTPQSTTPSPGQPHQPFHPPPQPSPAGGGPQPAYTPPTQQTYQLMCLHSQHVLPNPYFQPQPTPHHAPQNPQYQIVMQQHHAQ

Atx2

Ataxin-2 homolog

1084 amino acids

RNA binding protein that regulates various processes including circadian behaviors, actin filament formation, eye development and oocyte formation (PubMed:12524342, PubMed:28388438). Forms a complex with tyf and pAbp which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12 or me31B (PubMed:28388438). Forms an activator complex (Atx2-tyf activator complex) via association with Lsm12 and activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian locomotor behaviors (PubMed:28388438). Forms a repressor complex (Atx2-Not1 repressor complex) via the me31B-dependent association with Not1 to promote Not1-dependent post-transcriptional gene silencing and support high-amplitude circadian rhythms in a per-independent manner (PubMed:28388438). Regulates actin filament formation, though it does not directly assemble with actin filaments (PubMed:12524342). Required for oocyte specification and oocyte positioning in the female germline (PubMed:12524342). Also required for normal eye development and bristle morphology (PubMed:12524342).

Belongs to the ataxin-2 family.

117.578 kDa

MNNNSKRKTRPTGGGASGGISRYNSNDNSLRPTNNKAGAGGGNGGAAVRPSAQGVYNNTFFMHSATALVGSVVEVRLRSGNIYEGVFRTFSGNFDIALELPACIKSKNLPEEGKVPKHIIFPADTVVTIVAKDFDSQYATAGAFQTDGAISDKCNGARPDEKELEPWDSGANGDIDIELDSAANGWDPNEMFRKNENTFGVTSTFDDSLASYTVPLDKGDSLEFKEAEAKAEKLAAEIENNPTCRDRLDLENGDEEALFAAVERPSTEQDQRGDRGDRERNDRDREREERDRDRDRDRGNKPRGAGDFQLRETMSSDRYITKQTRSITGPQLSHVGMSSQGSGRDRDTRGDGSMMMQSGGGSGQGGSTQSTAALMLAGGLKGVGPAPSANASADSSSKYSGGSMVKRKTVPQGGKVMRNNVPTGGSNVSVSQGGNGNSVGQNKGGYQPSMGMPSQYSYQGNSQIMHGSSQYRNQSHMGGANKLNGDSNANTNKPLPQRQMRQYQGSQSNSSLNYGGEPQSLGKPVHGSHGGHPGQNSNSPPLQTAGPQQQQQQQQQQQQQQQQQQPPQQQQHQNIQPQGQNTQPARQVRTRDNQMQELRQFGQDFQLAPSNTSPPQQQQQQQQQQQQHQVQQQQQRALQQSASPPQQQQQQQQQQQHVVLHQVPQTHLHQAALSQPHYVPQQQPQQAPLPQQQHVPHHMQQKAQQQQLVETQHQHVQKQHQSQPQVQQPPPQLLQDPSQQPLPIYHTMPPPQTSPVVVTSPVLLEQPPPQPMPVVQQQQTQQLATPKPEVSPAPPSSNTTTPTGIASTPTAGVIASAGSEKTTPAAPTPTSNSATVPTGTAATAGGATGTTPVVKKHVLNPSAKPFTPRGPSTPNPSRPHTPQTPVPMTNIYTTTGGHVPPAANQPIYVMQPQHPFPPQTHPQAGQPPRLRRSNYPPMAASQMHVSASAATGQPLITAGPIPQFIQYGHAPHQQQFQSHTYAPMQMRVYPDQPQQLQFMTQTPQSTTPSPGQPHQQFHPPPQPSPAGGGPQPAFTPPTQAATYQLMCVHPQSLLANHYFPPPTPQHPQQNQQQYQIVMQQHQPQ

ATX2

Histone-lysine N-methyltransferase ATX2

1083 amino acids

Histone methyltransferase.

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.

123.287 kDa

MISMSCVPKEEEGEDTQIKTELHDHAADNPVRYASLESVYSVSSSSSSLCCKTAAGSHKKVNALKLPMSDSFELQPHRRPEIVHVYCRRKRRRRRRRESFLELAILQNEGVERDDRIVKIESAELDDEKEEENKKKKQKKRRIGNGELMKLGVDSTTLSVSATPPLRGCRIKAVCSGNKQDGSSRSKRNTVKNQEKVVTASATAKKWVRLSYDGVDPKHFIGLQCKVFWPLDAVWYPGSIVGYNVETKHHIVKYGDGDGEELALRREKIKFLISRDDMELLNMKFGTNDVVVDGQDYDELVILAASFEECQDFEPRDIIWAKLTGHAMWPAIIVDESVIVKRKGLNNKISGGRSVLVQFFGTHDFARIQVKQAVSFLKGLLSRSPLKCKQPRFEEAMEEAKMYLKEYKLPGRMDQLQKVADTDCSERINSGEEDSSNSGDDYTKDGEVWLRPTELGDCLHRIGDLQIINLGRIVTDSEFFKDSKHTWPEGYTATRKFISLKDPNASAMYKMEVLRDAESKTRPVFRVTTNSGEQFKGDTPSACWNKIYNRIKKIQIASDNPDVLGEGLHESGTDMFGFSNPEVDKLIQGLLQSRPPSKVSQRKYSSGKYQDHPTGYRPVRVEWKDLDKCNVCHMDEEYENNLFLQCDKCRMMVHTRCYGQLEPHNGILWLCNLCRPVALDIPPRCCLCPVVGGAMKPTTDGRWAHLACAIWIPETCLLDVKKMEPIDGVKKVSKDRWKLLCSICGVSYGACIQCSNNTCRVAYHPLCARAAGLCVELADEDRLFLLSMDDDEADQCIRLLSFCKRHRQTSNYHLETEYMIKPAHNIAEYLPPPNPSGCARTEPYNYLGRRGRKEPEALAGASSKRLFVENQPYIVGGYSRHEFSTYERIYGSKMSQITTPSNILSMAEKYTFMKETYRKRLAFGKSGIHGFGIFAKLPHRAGDMVIEYTGELVRPPIADKREHLIYNSMVGAGTYMFRIDNERVIDATRTGSIAHLINHSCEPNCYSRVISVNGDEHIIIFAKRDVAKWEELTYDYRFFSIDERLACYCGFPRCRGVVNDTEAEERQANIHASRCELKEWTES